Interaction between zinc, the GPR39 zinc receptor and the serotonergic system in depression

•Mild and severe zinc deficiency is a risk factor in developing depressive symptoms.•Zn2+ modulates the activity of the 5-HT1A receptor.•Monoamine-based antidepressants fail to display a therapeutic effect in GPR39 Kos.•GPR39 agonist TC-G 1008 causes antidepressant-like effects.•There is an interact...

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Veröffentlicht in:	Brain research bulletin 2021-05, Vol.170, p.146-154
Hauptverfasser:	Siodłak, Dominika, Nowak, Gabriel, Mlyniec, Katarzyna
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT1A Animals Depression Depressive Disorder - metabolism GPR39 Receptors, G-Protein-Coupled - metabolism Receptors, Serotonin - metabolism Serotonin Serotonin - metabolism Zinc Zinc - metabolism
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