A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices
•Anionic beta cyclodextrin retains drug into the layer-by-layer system•Anionic beta cyclodextrin controls drug release from the layer-by-layer system•The effective drug delivery system is readily tunable to different physiological scenarios•The drug delivery system shows antibacterial effect against...
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| Veröffentlicht in: | Carbohydrate polymers 2021-04, Vol.257, p.117604-117604, Article 117604 |
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| container_title | Carbohydrate polymers |
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| creator | Verza, Beatriz S. van den Beucken, Jeroen J.J.P. Brandt, João V. Jafelicci Junior, Miguel Barão, Valentim A.R. Piazza, Rodolfo D. Tagit, Oya Spolidorio, Denise M.P. Vergani, Carlos Eduardo de Avila, Erica D. |
| description | •Anionic beta cyclodextrin retains drug into the layer-by-layer system•Anionic beta cyclodextrin controls drug release from the layer-by-layer system•The effective drug delivery system is readily tunable to different physiological scenarios•The drug delivery system shows antibacterial effect against Staphylococcus aureus•An extended effect in bacteria reducing on coating was maintained up to 30 days
This study demonstrated a drug-delivery system with anionic beta cyclodextrin (β-CD) complexes to retain tetracycline (TC) and control its release from multilayers of poly(acrylic acid) (PAA) and poly(l-lysine) (PLL) in a ten double layers ([PAA/PLL]10) coating onto titanium. The drug-delivery capacity of the multilayer system was proven by controlled drug release over 15 days and sustained released over 30 days. Qualitative images confirmed TC retention within the layer-by-layer (LbL) over 30 days of incubation. Antibacterial activity of TC/anionic β-CD released from the LbL was established against Staphylococcus aureus species. Remarkably, [PAA/PLL]10/TC/anionic β-CD antibacterial effect was sustained even after 30 days of incubation. The non-cytotoxic effect of the multilayer system revealed normal human gingival fibroblast growth. It is expected that this novel approach and the chemical concept to improve drug incorporation into the multilayer system will open up possibilities to make the drug release system more applicable to implantable percutaneous devices. |
| doi_str_mv | 10.1016/j.carbpol.2020.117604 |
| format | Article |
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This study demonstrated a drug-delivery system with anionic beta cyclodextrin (β-CD) complexes to retain tetracycline (TC) and control its release from multilayers of poly(acrylic acid) (PAA) and poly(l-lysine) (PLL) in a ten double layers ([PAA/PLL]10) coating onto titanium. The drug-delivery capacity of the multilayer system was proven by controlled drug release over 15 days and sustained released over 30 days. Qualitative images confirmed TC retention within the layer-by-layer (LbL) over 30 days of incubation. Antibacterial activity of TC/anionic β-CD released from the LbL was established against Staphylococcus aureus species. Remarkably, [PAA/PLL]10/TC/anionic β-CD antibacterial effect was sustained even after 30 days of incubation. The non-cytotoxic effect of the multilayer system revealed normal human gingival fibroblast growth. It is expected that this novel approach and the chemical concept to improve drug incorporation into the multilayer system will open up possibilities to make the drug release system more applicable to implantable percutaneous devices.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2020.117604</identifier><identifier>PMID: 33541637</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Coating ; Cyclodextrin ; Drug delivery ; Layer-By-Layer ; Percutaneous device</subject><ispartof>Carbohydrate polymers, 2021-04, Vol.257, p.117604-117604, Article 117604</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-f6158b271f32f0c61c9635ea74eaf17b7a9268a08cc7be0a060cde64aaefeba13</citedby><cites>FETCH-LOGICAL-c365t-f6158b271f32f0c61c9635ea74eaf17b7a9268a08cc7be0a060cde64aaefeba13</cites><orcidid>0000-0002-0301-1966 ; 0000-0003-1897-843X ; 0000-0002-7375-4714 ; 0000-0002-6391-9917 ; 0000-0002-5773-6647 ; 0000-0001-6681-1269</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2020.117604$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33541637$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verza, Beatriz S.</creatorcontrib><creatorcontrib>van den Beucken, Jeroen J.J.P.</creatorcontrib><creatorcontrib>Brandt, João V.</creatorcontrib><creatorcontrib>Jafelicci Junior, Miguel</creatorcontrib><creatorcontrib>Barão, Valentim A.R.</creatorcontrib><creatorcontrib>Piazza, Rodolfo D.</creatorcontrib><creatorcontrib>Tagit, Oya</creatorcontrib><creatorcontrib>Spolidorio, Denise M.P.</creatorcontrib><creatorcontrib>Vergani, Carlos Eduardo</creatorcontrib><creatorcontrib>de Avila, Erica D.</creatorcontrib><title>A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>•Anionic beta cyclodextrin retains drug into the layer-by-layer system•Anionic beta cyclodextrin controls drug release from the layer-by-layer system•The effective drug delivery system is readily tunable to different physiological scenarios•The drug delivery system shows antibacterial effect against Staphylococcus aureus•An extended effect in bacteria reducing on coating was maintained up to 30 days
This study demonstrated a drug-delivery system with anionic beta cyclodextrin (β-CD) complexes to retain tetracycline (TC) and control its release from multilayers of poly(acrylic acid) (PAA) and poly(l-lysine) (PLL) in a ten double layers ([PAA/PLL]10) coating onto titanium. The drug-delivery capacity of the multilayer system was proven by controlled drug release over 15 days and sustained released over 30 days. Qualitative images confirmed TC retention within the layer-by-layer (LbL) over 30 days of incubation. Antibacterial activity of TC/anionic β-CD released from the LbL was established against Staphylococcus aureus species. Remarkably, [PAA/PLL]10/TC/anionic β-CD antibacterial effect was sustained even after 30 days of incubation. The non-cytotoxic effect of the multilayer system revealed normal human gingival fibroblast growth. It is expected that this novel approach and the chemical concept to improve drug incorporation into the multilayer system will open up possibilities to make the drug release system more applicable to implantable percutaneous devices.</description><subject>Coating</subject><subject>Cyclodextrin</subject><subject>Drug delivery</subject><subject>Layer-By-Layer</subject><subject>Percutaneous device</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFUU1v1DAQtRAV3X78BJCPXLzYiWNnT6iqCkWqxIWeLceZLF45drCdpfkF_G28ZOHKXGY08958PYTeMrpllIkPh63RsZuC21a0KjkmBeWv0Ia1ckdYzflrtKGMc9IKJi_RVUoHWkww-gZd1nXDmajlBv26wy74PckQR2yCzzE4Bz3u47wnPTh7hLjgnzZ_x9rb4K3BHWSNzWJc6OElR-sLb5wcvOASOr1AJN1C_gSlorP1ezyEiCeIZs7aQ5gTtoWhfU64h6M1kG7QxaBdgtuzv0bPnx6-3T-Sp6-fv9zfPRFTiyaTQbCm7SrJhroaqBHM7ETdgJYc9MBkJ_WuEq2mrTGyA6qpoKYHwbWGATrN6mv0fu07xfBjhpTVaJMB59a9VMVbyQQV4gRtVqiJIaUIg5qiHXVcFKPqpIE6qLMG6qSBWjUovHfnEXM3Qv-P9ffpBfBxBUA59GghqmQseAO9jWCy6oP9z4jfXdCedA</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Verza, Beatriz S.</creator><creator>van den Beucken, Jeroen J.J.P.</creator><creator>Brandt, João V.</creator><creator>Jafelicci Junior, Miguel</creator><creator>Barão, Valentim A.R.</creator><creator>Piazza, Rodolfo D.</creator><creator>Tagit, Oya</creator><creator>Spolidorio, Denise M.P.</creator><creator>Vergani, Carlos Eduardo</creator><creator>de Avila, Erica D.</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0301-1966</orcidid><orcidid>https://orcid.org/0000-0003-1897-843X</orcidid><orcidid>https://orcid.org/0000-0002-7375-4714</orcidid><orcidid>https://orcid.org/0000-0002-6391-9917</orcidid><orcidid>https://orcid.org/0000-0002-5773-6647</orcidid><orcidid>https://orcid.org/0000-0001-6681-1269</orcidid></search><sort><creationdate>20210401</creationdate><title>A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices</title><author>Verza, Beatriz S. ; van den Beucken, Jeroen J.J.P. ; Brandt, João V. ; Jafelicci Junior, Miguel ; Barão, Valentim A.R. ; Piazza, Rodolfo D. ; Tagit, Oya ; Spolidorio, Denise M.P. ; Vergani, Carlos Eduardo ; de Avila, Erica D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-f6158b271f32f0c61c9635ea74eaf17b7a9268a08cc7be0a060cde64aaefeba13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Coating</topic><topic>Cyclodextrin</topic><topic>Drug delivery</topic><topic>Layer-By-Layer</topic><topic>Percutaneous device</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verza, Beatriz S.</creatorcontrib><creatorcontrib>van den Beucken, Jeroen J.J.P.</creatorcontrib><creatorcontrib>Brandt, João V.</creatorcontrib><creatorcontrib>Jafelicci Junior, Miguel</creatorcontrib><creatorcontrib>Barão, Valentim A.R.</creatorcontrib><creatorcontrib>Piazza, Rodolfo D.</creatorcontrib><creatorcontrib>Tagit, Oya</creatorcontrib><creatorcontrib>Spolidorio, Denise M.P.</creatorcontrib><creatorcontrib>Vergani, Carlos Eduardo</creatorcontrib><creatorcontrib>de Avila, Erica D.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verza, Beatriz S.</au><au>van den Beucken, Jeroen J.J.P.</au><au>Brandt, João V.</au><au>Jafelicci Junior, Miguel</au><au>Barão, Valentim A.R.</au><au>Piazza, Rodolfo D.</au><au>Tagit, Oya</au><au>Spolidorio, Denise M.P.</au><au>Vergani, Carlos Eduardo</au><au>de Avila, Erica D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>257</volume><spage>117604</spage><epage>117604</epage><pages>117604-117604</pages><artnum>117604</artnum><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>•Anionic beta cyclodextrin retains drug into the layer-by-layer system•Anionic beta cyclodextrin controls drug release from the layer-by-layer system•The effective drug delivery system is readily tunable to different physiological scenarios•The drug delivery system shows antibacterial effect against Staphylococcus aureus•An extended effect in bacteria reducing on coating was maintained up to 30 days
This study demonstrated a drug-delivery system with anionic beta cyclodextrin (β-CD) complexes to retain tetracycline (TC) and control its release from multilayers of poly(acrylic acid) (PAA) and poly(l-lysine) (PLL) in a ten double layers ([PAA/PLL]10) coating onto titanium. The drug-delivery capacity of the multilayer system was proven by controlled drug release over 15 days and sustained released over 30 days. Qualitative images confirmed TC retention within the layer-by-layer (LbL) over 30 days of incubation. Antibacterial activity of TC/anionic β-CD released from the LbL was established against Staphylococcus aureus species. Remarkably, [PAA/PLL]10/TC/anionic β-CD antibacterial effect was sustained even after 30 days of incubation. The non-cytotoxic effect of the multilayer system revealed normal human gingival fibroblast growth. It is expected that this novel approach and the chemical concept to improve drug incorporation into the multilayer system will open up possibilities to make the drug release system more applicable to implantable percutaneous devices.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33541637</pmid><doi>10.1016/j.carbpol.2020.117604</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0301-1966</orcidid><orcidid>https://orcid.org/0000-0003-1897-843X</orcidid><orcidid>https://orcid.org/0000-0002-7375-4714</orcidid><orcidid>https://orcid.org/0000-0002-6391-9917</orcidid><orcidid>https://orcid.org/0000-0002-5773-6647</orcidid><orcidid>https://orcid.org/0000-0001-6681-1269</orcidid></addata></record> |
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| ispartof | Carbohydrate polymers, 2021-04, Vol.257, p.117604-117604, Article 117604 |
| issn | 0144-8617 1879-1344 |
| language | eng |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Coating Cyclodextrin Drug delivery Layer-By-Layer Percutaneous device |
| title | A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices |
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