Myeloid neoplasms in the setting of chronic lymphocytic leukaemia/chronic lymphocytic leukaemia-like disease: a clinicopathological study of 66 cases comparing cases with prior history of treatment to those without
AimsMyeloid neoplasms occur in the setting of chronic lymphocytic leukaemia (CLL)/CLL-like disease. The underlying pathogenesis has not been elucidated.MethodsRetrospectively analysed 66 cases of myeloid neoplasms in patients with CLL/CLL-like disease.ResultsOf these, 33 patients (group 1) had recei...
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| Veröffentlicht in: | Journal of clinical pathology 2022-05, Vol.75 (5), p.292-301 |
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| creator | Luedke, Catherine Zhao, Yue McCracken, Jenna Maule, Jake Yang, Lian-He Jug, Rachel Galeotti, Jonathan Siddiqi, Imran Gong, Jerald Lu, Chuanyi Mark Wang, Endi |
| description | AimsMyeloid neoplasms occur in the setting of chronic lymphocytic leukaemia (CLL)/CLL-like disease. The underlying pathogenesis has not been elucidated.MethodsRetrospectively analysed 66 cases of myeloid neoplasms in patients with CLL/CLL-like disease.ResultsOf these, 33 patients (group 1) had received treatment for CLL/CLL-like disease, while the other 33 patients (group 2) had either concurrent diagnoses or untreated CLL/CLL-like disease before identifying myeloid neoplasms. The two categories had distinct features in clinical presentation, spectrum of myeloid neoplasm, morphology, cytogenetic profile and clinical outcome. Compared with group 2, group 1 demonstrated a younger age at the diagnosis of myeloid neoplasm (median, 65 vs 71 years), a higher fraction of myelodysplastic syndrome (64% vs 36%; OR: 3.1; p |
| doi_str_mv | 10.1136/jclinpath-2020-207334 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2487158875</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2887933301</sourcerecordid><originalsourceid>FETCH-LOGICAL-b327t-898996a342052b0bca46976e4e80b74805d2122ce671e0e0b4f966e97a9c12e53</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS0EopcLjwCyxIZNqP9iJ-xQRQtSKzbtOnKcuY1vnTjYjlBelOfBaUqRuujG9sjfnDn2Qeg9JZ8p5fL0aJwdJ536ghFG8qI4Fy_QjgrFCkGFfIl2hDBa1ErIE_QmxiMhlCvKX6MTzkvBKKl26M_VAs7bDo_gJ6fjELEdceoBR0jJjrfYH7Dpgx-twW4Zpt6bJa1nmO80DFafPntbOHsHuLMRdIQvWOPVtjV-de6dv7VGOxzT3C3rICmxyVzExg-TDuv4rf5tU4-nYH3AvY3Jh3s8BdBpgDHh5LNnH-Ee9HN6i14dtIvw7mHfo5vzb9dn34vLnxc_zr5eFi1nKhVVXdW11FwwUrKWtEYLWSsJAirSKlGRsmOUMQNSUSBAWnGopYRa6dpQBiXfo0-b7hT8rxliagYbDTin83_OsWGiUrSsKrWiH5-gRz-HMbtrWAZqznnOZ4_KjTLBxxjg0ORXDzosDSXNGnzzGHyzBt9swee-Dw_qcztA99j1L-kM0A1oh-P_yc-L_gUHTMEA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2887933301</pqid></control><display><type>article</type><title>Myeloid neoplasms in the setting of chronic lymphocytic leukaemia/chronic lymphocytic leukaemia-like disease: a clinicopathological study of 66 cases comparing cases with prior history of treatment to those without</title><source>MEDLINE</source><source>PubMed Central</source><creator>Luedke, Catherine ; Zhao, Yue ; McCracken, Jenna ; Maule, Jake ; Yang, Lian-He ; Jug, Rachel ; Galeotti, Jonathan ; Siddiqi, Imran ; Gong, Jerald ; Lu, Chuanyi Mark ; Wang, Endi</creator><creatorcontrib>Luedke, Catherine ; Zhao, Yue ; McCracken, Jenna ; Maule, Jake ; Yang, Lian-He ; Jug, Rachel ; Galeotti, Jonathan ; Siddiqi, Imran ; Gong, Jerald ; Lu, Chuanyi Mark ; Wang, Endi</creatorcontrib><description>AimsMyeloid neoplasms occur in the setting of chronic lymphocytic leukaemia (CLL)/CLL-like disease. The underlying pathogenesis has not been elucidated.MethodsRetrospectively analysed 66 cases of myeloid neoplasms in patients with CLL/CLL-like disease.ResultsOf these, 33 patients (group 1) had received treatment for CLL/CLL-like disease, while the other 33 patients (group 2) had either concurrent diagnoses or untreated CLL/CLL-like disease before identifying myeloid neoplasms. The two categories had distinct features in clinical presentation, spectrum of myeloid neoplasm, morphology, cytogenetic profile and clinical outcome. Compared with group 2, group 1 demonstrated a younger age at the diagnosis of myeloid neoplasm (median, 65 vs 71 years), a higher fraction of myelodysplastic syndrome (64% vs 36%; OR: 3.1; p<0.05), a higher rate of adverse unbalanced cytogenetic abnormalities, including complex changes, −5/5q- and/or −7/7q- (83% vs 28%; OR: 13.1; p<0.001) and a shorter overall survival (median, 12 vs 44 months; p<0.05).ConclusionsMyeloid neoplasm in the setting of CLL/CLL-like disease can be divided into two categories, one with prior treatment for CLL/CLL-like disease and the other without. CLL-type treatment may accelerate myeloid leukaemogenesis. The risk is estimated to be 13-fold higher in patients with treatment than those without. The causative agent could be attributed to fludarabine in combination with alkylators, based on the latency of myeloid leukaemogenesis and the cytogenetic profile.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jclinpath-2020-207334</identifier><identifier>PMID: 33542108</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Bone marrow ; Cancer therapies ; Flow cytometry ; Humans ; Leukemia ; Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell - genetics ; Leukemia, Myeloid ; Lymphoma ; Myelodysplastic syndromes ; Myelodysplastic Syndromes - pathology ; myeloid ; Myeloproliferative Disorders ; Original research ; Pathogenesis ; Patients ; Retrospective Studies ; Skin cancer ; Survival analysis ; Tumors</subject><ispartof>Journal of clinical pathology, 2022-05, Vol.75 (5), p.292-301</ispartof><rights>Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2022 Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-b327t-898996a342052b0bca46976e4e80b74805d2122ce671e0e0b4f966e97a9c12e53</cites><orcidid>0000-0001-6132-6336</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33542108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luedke, Catherine</creatorcontrib><creatorcontrib>Zhao, Yue</creatorcontrib><creatorcontrib>McCracken, Jenna</creatorcontrib><creatorcontrib>Maule, Jake</creatorcontrib><creatorcontrib>Yang, Lian-He</creatorcontrib><creatorcontrib>Jug, Rachel</creatorcontrib><creatorcontrib>Galeotti, Jonathan</creatorcontrib><creatorcontrib>Siddiqi, Imran</creatorcontrib><creatorcontrib>Gong, Jerald</creatorcontrib><creatorcontrib>Lu, Chuanyi Mark</creatorcontrib><creatorcontrib>Wang, Endi</creatorcontrib><title>Myeloid neoplasms in the setting of chronic lymphocytic leukaemia/chronic lymphocytic leukaemia-like disease: a clinicopathological study of 66 cases comparing cases with prior history of treatment to those without</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><addtitle>J Clin Pathol</addtitle><description>AimsMyeloid neoplasms occur in the setting of chronic lymphocytic leukaemia (CLL)/CLL-like disease. The underlying pathogenesis has not been elucidated.MethodsRetrospectively analysed 66 cases of myeloid neoplasms in patients with CLL/CLL-like disease.ResultsOf these, 33 patients (group 1) had received treatment for CLL/CLL-like disease, while the other 33 patients (group 2) had either concurrent diagnoses or untreated CLL/CLL-like disease before identifying myeloid neoplasms. The two categories had distinct features in clinical presentation, spectrum of myeloid neoplasm, morphology, cytogenetic profile and clinical outcome. Compared with group 2, group 1 demonstrated a younger age at the diagnosis of myeloid neoplasm (median, 65 vs 71 years), a higher fraction of myelodysplastic syndrome (64% vs 36%; OR: 3.1; p<0.05), a higher rate of adverse unbalanced cytogenetic abnormalities, including complex changes, −5/5q- and/or −7/7q- (83% vs 28%; OR: 13.1; p<0.001) and a shorter overall survival (median, 12 vs 44 months; p<0.05).ConclusionsMyeloid neoplasm in the setting of CLL/CLL-like disease can be divided into two categories, one with prior treatment for CLL/CLL-like disease and the other without. CLL-type treatment may accelerate myeloid leukaemogenesis. The risk is estimated to be 13-fold higher in patients with treatment than those without. The causative agent could be attributed to fludarabine in combination with alkylators, based on the latency of myeloid leukaemogenesis and the cytogenetic profile.</description><subject>Bone marrow</subject><subject>Cancer therapies</subject><subject>Flow cytometry</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</subject><subject>Leukemia, Myeloid</subject><subject>Lymphoma</subject><subject>Myelodysplastic syndromes</subject><subject>Myelodysplastic Syndromes - pathology</subject><subject>myeloid</subject><subject>Myeloproliferative Disorders</subject><subject>Original research</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Skin cancer</subject><subject>Survival analysis</subject><subject>Tumors</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1u1TAQhS0EopcLjwCyxIZNqP9iJ-xQRQtSKzbtOnKcuY1vnTjYjlBelOfBaUqRuujG9sjfnDn2Qeg9JZ8p5fL0aJwdJ536ghFG8qI4Fy_QjgrFCkGFfIl2hDBa1ErIE_QmxiMhlCvKX6MTzkvBKKl26M_VAs7bDo_gJ6fjELEdceoBR0jJjrfYH7Dpgx-twW4Zpt6bJa1nmO80DFafPntbOHsHuLMRdIQvWOPVtjV-de6dv7VGOxzT3C3rICmxyVzExg-TDuv4rf5tU4-nYH3AvY3Jh3s8BdBpgDHh5LNnH-Ee9HN6i14dtIvw7mHfo5vzb9dn34vLnxc_zr5eFi1nKhVVXdW11FwwUrKWtEYLWSsJAirSKlGRsmOUMQNSUSBAWnGopYRa6dpQBiXfo0-b7hT8rxliagYbDTin83_OsWGiUrSsKrWiH5-gRz-HMbtrWAZqznnOZ4_KjTLBxxjg0ORXDzosDSXNGnzzGHyzBt9swee-Dw_qcztA99j1L-kM0A1oh-P_yc-L_gUHTMEA</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Luedke, Catherine</creator><creator>Zhao, Yue</creator><creator>McCracken, Jenna</creator><creator>Maule, Jake</creator><creator>Yang, Lian-He</creator><creator>Jug, Rachel</creator><creator>Galeotti, Jonathan</creator><creator>Siddiqi, Imran</creator><creator>Gong, Jerald</creator><creator>Lu, Chuanyi Mark</creator><creator>Wang, Endi</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6132-6336</orcidid></search><sort><creationdate>20220501</creationdate><title>Myeloid neoplasms in the setting of chronic lymphocytic leukaemia/chronic lymphocytic leukaemia-like disease: a clinicopathological study of 66 cases comparing cases with prior history of treatment to those without</title><author>Luedke, Catherine ; Zhao, Yue ; McCracken, Jenna ; Maule, Jake ; Yang, Lian-He ; Jug, Rachel ; Galeotti, Jonathan ; Siddiqi, Imran ; Gong, Jerald ; Lu, Chuanyi Mark ; Wang, Endi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b327t-898996a342052b0bca46976e4e80b74805d2122ce671e0e0b4f966e97a9c12e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bone marrow</topic><topic>Cancer therapies</topic><topic>Flow cytometry</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</topic><topic>Leukemia, Myeloid</topic><topic>Lymphoma</topic><topic>Myelodysplastic syndromes</topic><topic>Myelodysplastic Syndromes - pathology</topic><topic>myeloid</topic><topic>Myeloproliferative Disorders</topic><topic>Original research</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Skin cancer</topic><topic>Survival analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luedke, Catherine</creatorcontrib><creatorcontrib>Zhao, Yue</creatorcontrib><creatorcontrib>McCracken, Jenna</creatorcontrib><creatorcontrib>Maule, Jake</creatorcontrib><creatorcontrib>Yang, Lian-He</creatorcontrib><creatorcontrib>Jug, Rachel</creatorcontrib><creatorcontrib>Galeotti, Jonathan</creatorcontrib><creatorcontrib>Siddiqi, Imran</creatorcontrib><creatorcontrib>Gong, Jerald</creatorcontrib><creatorcontrib>Lu, Chuanyi Mark</creatorcontrib><creatorcontrib>Wang, Endi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luedke, Catherine</au><au>Zhao, Yue</au><au>McCracken, Jenna</au><au>Maule, Jake</au><au>Yang, Lian-He</au><au>Jug, Rachel</au><au>Galeotti, Jonathan</au><au>Siddiqi, Imran</au><au>Gong, Jerald</au><au>Lu, Chuanyi Mark</au><au>Wang, Endi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myeloid neoplasms in the setting of chronic lymphocytic leukaemia/chronic lymphocytic leukaemia-like disease: a clinicopathological study of 66 cases comparing cases with prior history of treatment to those without</atitle><jtitle>Journal of clinical pathology</jtitle><stitle>J Clin Pathol</stitle><addtitle>J Clin Pathol</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>75</volume><issue>5</issue><spage>292</spage><epage>301</epage><pages>292-301</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><abstract>AimsMyeloid neoplasms occur in the setting of chronic lymphocytic leukaemia (CLL)/CLL-like disease. The underlying pathogenesis has not been elucidated.MethodsRetrospectively analysed 66 cases of myeloid neoplasms in patients with CLL/CLL-like disease.ResultsOf these, 33 patients (group 1) had received treatment for CLL/CLL-like disease, while the other 33 patients (group 2) had either concurrent diagnoses or untreated CLL/CLL-like disease before identifying myeloid neoplasms. The two categories had distinct features in clinical presentation, spectrum of myeloid neoplasm, morphology, cytogenetic profile and clinical outcome. Compared with group 2, group 1 demonstrated a younger age at the diagnosis of myeloid neoplasm (median, 65 vs 71 years), a higher fraction of myelodysplastic syndrome (64% vs 36%; OR: 3.1; p<0.05), a higher rate of adverse unbalanced cytogenetic abnormalities, including complex changes, −5/5q- and/or −7/7q- (83% vs 28%; OR: 13.1; p<0.001) and a shorter overall survival (median, 12 vs 44 months; p<0.05).ConclusionsMyeloid neoplasm in the setting of CLL/CLL-like disease can be divided into two categories, one with prior treatment for CLL/CLL-like disease and the other without. CLL-type treatment may accelerate myeloid leukaemogenesis. The risk is estimated to be 13-fold higher in patients with treatment than those without. The causative agent could be attributed to fludarabine in combination with alkylators, based on the latency of myeloid leukaemogenesis and the cytogenetic profile.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>33542108</pmid><doi>10.1136/jclinpath-2020-207334</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6132-6336</orcidid></addata></record> |
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| subjects | Bone marrow Cancer therapies Flow cytometry Humans Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Myeloid Lymphoma Myelodysplastic syndromes Myelodysplastic Syndromes - pathology myeloid Myeloproliferative Disorders Original research Pathogenesis Patients Retrospective Studies Skin cancer Survival analysis Tumors |
| title | Myeloid neoplasms in the setting of chronic lymphocytic leukaemia/chronic lymphocytic leukaemia-like disease: a clinicopathological study of 66 cases comparing cases with prior history of treatment to those without |
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