Levodopa Causes Striatal Cholinergic Interneuron Burst‐Pause Activity in Parkinsonian Mice

Background Enhanced striatal cholinergic interneuron activity contributes to the striatal hypercholinergic state in Parkinson's disease (PD) and to levodopa‐induced dyskinesia. In severe PD, dyskinesia and motor fluctuations become seriously debilitating, and the therapeutic strategies become s...

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Veröffentlicht in:	Movement disorders 2021-07, Vol.36 (7), p.1578-1591
Hauptverfasser:	Paz, Rodrigo Manuel, Tubert, Cecilia, Stahl, Agostina Monica, Amarillo, Yimy, Rela, Lorena, Murer, Mario Gustavo
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticholinergics Basal ganglia Central nervous system diseases Cyclic AMP Dopamine D1 receptors Dopamine D5 receptors Dyskinesia Interneurons Ion channels Leak channels Levodopa l‐dopa‐induced dyskinesia Movement disorders Neostriatum Neurodegenerative diseases Parkinson's disease Potassium channels (inwardly-rectifying) striatal cholinergic interneurons
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