Spatial distribution of Escherichia coli ST131 C subclades in a centralized Canadian urban region

Spatial distribution of Escherichia coli ST131 C subclades in a centralized Canadian urban region

Abstract Introduction Escherichia coli ST131 is the most common multidrug-resistant (MDR) E. coli clone causing bloodstream infections (BSIs) in Calgary. This study describes patient characteristics and spatial distribution of ST131 subclades C1 and C2 causing BSIs in Calgary. Methods E. coli from b...

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Veröffentlicht in:Journal of antimicrobial chemotherapy 2021-04, Vol.76 (5), p.1135-1139
Hauptverfasser: Nobrega, Diego, Peirano, Gisele, Lynch, Tarah, Finn, Thomas J, Devinney, Rebekah, Pitout, Johann D D
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container_end_page 1139
container_issue 5
container_start_page 1135
container_title Journal of antimicrobial chemotherapy
container_volume 76
creator Nobrega, Diego
Peirano, Gisele
Lynch, Tarah
Finn, Thomas J
Devinney, Rebekah
Pitout, Johann D D
description Abstract Introduction Escherichia coli ST131 is the most common multidrug-resistant (MDR) E. coli clone causing bloodstream infections (BSIs) in Calgary. This study describes patient characteristics and spatial distribution of ST131 subclades C1 and C2 causing BSIs in Calgary. Methods E. coli from blood (n = 685) obtained in Calgary, Canada, (2016) were PCR screened for ST131 and positives (n = 141) underwent whole genome sequencing. Patient characteristics were analysed using Fisher’s Exact/t-tests and spatial analysis was used to identify clusters. Results Overall, 21% of E. coli was identified as ST131 and clade C dominated the population. ST131-C2 was associated with blaCTX-M-15 and significantly more MDR than ST131-C1. The spatial distribution in Calgary showed that ST131-C1 was mainly present in long-term care (LTC) residents whereas ST131-C2 clustered in a specific North East (NE) Calgary sector comprising of six neighbourhoods without LTC centres. This NE sector has high immigration and travel rates from the Indian subcontinent. Conclusions This study showed that ST131 C subclades have different geographical distribution patterns in Calgary. We believe that recent travel to and immigration from certain high-risk regions for antimicrobial resistance are responsible for the ST131-C2 NE Calgary clustering pattern.
doi_str_mv 10.1093/jac/dkab020
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This study describes patient characteristics and spatial distribution of ST131 subclades C1 and C2 causing BSIs in Calgary. Methods E. coli from blood (n = 685) obtained in Calgary, Canada, (2016) were PCR screened for ST131 and positives (n = 141) underwent whole genome sequencing. Patient characteristics were analysed using Fisher’s Exact/t-tests and spatial analysis was used to identify clusters. Results Overall, 21% of E. coli was identified as ST131 and clade C dominated the population. ST131-C2 was associated with blaCTX-M-15 and significantly more MDR than ST131-C1. The spatial distribution in Calgary showed that ST131-C1 was mainly present in long-term care (LTC) residents whereas ST131-C2 clustered in a specific North East (NE) Calgary sector comprising of six neighbourhoods without LTC centres. This NE sector has high immigration and travel rates from the Indian subcontinent. Conclusions This study showed that ST131 C subclades have different geographical distribution patterns in Calgary. We believe that recent travel to and immigration from certain high-risk regions for antimicrobial resistance are responsible for the ST131-C2 NE Calgary clustering pattern.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkab020</identifier><identifier>PMID: 33547472</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><ispartof>Journal of antimicrobial chemotherapy, 2021-04, Vol.76 (5), p.1135-1139</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com. 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-1df4515896285feb9fa575001c8062ac6ae9e48647b0c8d2eb7ced2dc0a711653</citedby><cites>FETCH-LOGICAL-c320t-1df4515896285feb9fa575001c8062ac6ae9e48647b0c8d2eb7ced2dc0a711653</cites><orcidid>0000-0002-4547-4707 ; 0000-0001-9821-1436</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1585,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33547472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nobrega, Diego</creatorcontrib><creatorcontrib>Peirano, Gisele</creatorcontrib><creatorcontrib>Lynch, Tarah</creatorcontrib><creatorcontrib>Finn, Thomas J</creatorcontrib><creatorcontrib>Devinney, Rebekah</creatorcontrib><creatorcontrib>Pitout, Johann D D</creatorcontrib><title>Spatial distribution of Escherichia coli ST131 C subclades in a centralized Canadian urban region</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Abstract Introduction Escherichia coli ST131 is the most common multidrug-resistant (MDR) E. coli clone causing bloodstream infections (BSIs) in Calgary. This study describes patient characteristics and spatial distribution of ST131 subclades C1 and C2 causing BSIs in Calgary. Methods E. coli from blood (n = 685) obtained in Calgary, Canada, (2016) were PCR screened for ST131 and positives (n = 141) underwent whole genome sequencing. Patient characteristics were analysed using Fisher’s Exact/t-tests and spatial analysis was used to identify clusters. Results Overall, 21% of E. coli was identified as ST131 and clade C dominated the population. ST131-C2 was associated with blaCTX-M-15 and significantly more MDR than ST131-C1. The spatial distribution in Calgary showed that ST131-C1 was mainly present in long-term care (LTC) residents whereas ST131-C2 clustered in a specific North East (NE) Calgary sector comprising of six neighbourhoods without LTC centres. This NE sector has high immigration and travel rates from the Indian subcontinent. Conclusions This study showed that ST131 C subclades have different geographical distribution patterns in Calgary. We believe that recent travel to and immigration from certain high-risk regions for antimicrobial resistance are responsible for the ST131-C2 NE Calgary clustering pattern.</description><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kDtPwzAURi0EoqUwsSNPCAmFXr_yGFFUHlIlhpY5urEd6pImwU4G-PUEtTCy3G-4R2c4hFwyuGOQifkW9dy8YwkcjsiUyRgiDhk7JlMQoKJEKjEhZyFsASBWcXpKJkIomciETwmuOuwd1tS40HtXDr1rG9pWdBH0xnqnNw6pbmtHV2smGM1pGEpdo7GBuoaOP9v0Hmv3ZQ3NsUHjsKGDL8fr7dsoOycnFdbBXhx2Rl4fFuv8KVq-PD7n98tICw59xEwlFVNpFvNUVbbMKlSJAmA6hZijjtFmVqaxTErQqeG2TLQ13GjAhLFYiRm52Xs7334MNvTFzgVt6xob2w6h4DJNmFKCwYje7lHt2xC8rYrOux36z4JB8dO0GJsWh6YjfXUQD-XOmj_2N-IIXO-Bduj-NX0DYpZ_ZQ</recordid><startdate>20210413</startdate><enddate>20210413</enddate><creator>Nobrega, Diego</creator><creator>Peirano, Gisele</creator><creator>Lynch, Tarah</creator><creator>Finn, Thomas J</creator><creator>Devinney, Rebekah</creator><creator>Pitout, Johann D D</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4547-4707</orcidid><orcidid>https://orcid.org/0000-0001-9821-1436</orcidid></search><sort><creationdate>20210413</creationdate><title>Spatial distribution of Escherichia coli ST131 C subclades in a centralized Canadian urban region</title><author>Nobrega, Diego ; Peirano, Gisele ; Lynch, Tarah ; Finn, Thomas J ; Devinney, Rebekah ; Pitout, Johann D D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-1df4515896285feb9fa575001c8062ac6ae9e48647b0c8d2eb7ced2dc0a711653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nobrega, Diego</creatorcontrib><creatorcontrib>Peirano, Gisele</creatorcontrib><creatorcontrib>Lynch, Tarah</creatorcontrib><creatorcontrib>Finn, Thomas J</creatorcontrib><creatorcontrib>Devinney, Rebekah</creatorcontrib><creatorcontrib>Pitout, Johann D D</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nobrega, Diego</au><au>Peirano, Gisele</au><au>Lynch, Tarah</au><au>Finn, Thomas J</au><au>Devinney, Rebekah</au><au>Pitout, Johann D D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spatial distribution of Escherichia coli ST131 C subclades in a centralized Canadian urban region</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>2021-04-13</date><risdate>2021</risdate><volume>76</volume><issue>5</issue><spage>1135</spage><epage>1139</epage><pages>1135-1139</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><abstract>Abstract Introduction Escherichia coli ST131 is the most common multidrug-resistant (MDR) E. coli clone causing bloodstream infections (BSIs) in Calgary. This study describes patient characteristics and spatial distribution of ST131 subclades C1 and C2 causing BSIs in Calgary. Methods E. coli from blood (n = 685) obtained in Calgary, Canada, (2016) were PCR screened for ST131 and positives (n = 141) underwent whole genome sequencing. Patient characteristics were analysed using Fisher’s Exact/t-tests and spatial analysis was used to identify clusters. Results Overall, 21% of E. coli was identified as ST131 and clade C dominated the population. ST131-C2 was associated with blaCTX-M-15 and significantly more MDR than ST131-C1. The spatial distribution in Calgary showed that ST131-C1 was mainly present in long-term care (LTC) residents whereas ST131-C2 clustered in a specific North East (NE) Calgary sector comprising of six neighbourhoods without LTC centres. This NE sector has high immigration and travel rates from the Indian subcontinent. 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title Spatial distribution of Escherichia coli ST131 C subclades in a centralized Canadian urban region
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