Planar cell polarity pathway in kidney development, function and disease

Planar cell polarity (PCP) refers to the coordinated orientation of cells in the tissue plane. Originally discovered and studied in Drosophila melanogaster , PCP is now widely recognized in vertebrates, where it is implicated in organogenesis. Specific sets of PCP genes have been identified. The pro...

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Veröffentlicht in:	Nature reviews. Nephrology 2021-06, Vol.17 (6), p.369-385
Hauptverfasser:	Torban, Elena, Sokol, Sergei Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/1425 631/80/304 631/80/86 692/4022/1585 Animals Cell adhesion & migration Cell Polarity - physiology Cellular signal transduction Congenital diseases Drosophila - growth & development Embryos Gene mutations Genetic aspects Health aspects Humans Insects Kidney - embryology Kidney - growth & development Kidney - physiology Kidney diseases Kidney Diseases - etiology Kidney Diseases - physiopathology Kidneys Kinases Medicine Medicine & Public Health Mutation Nephrology Proteins Regulation Review Article Signal Transduction - physiology Urogenital system Vertebrates
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