Influence of the human immunodeficiency virus on cervical precancerous lesions

Influence of the human immunodeficiency virus on cervical precancerous lesions

Objective To study the influence of HIV status on the occurrence of cervical precancerous lesions (CPL). Methods This analytical cross‐sectional study was carried out between December 1, 2019 and May 31, 2020. All women with documented HIV status screened for CPL with biopsies performed were recruit...

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Veröffentlicht in:International journal of gynecology and obstetrics 2021-09, Vol.154 (3), p.540-543
Hauptverfasser: Nkwabong, Elie, Kengne, Berenis, Nkene Mawamba, Yvette, Sando, Zacharie
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CD4 count
cervical precancerous lesions
high‐grade lesions
human immunodeficiency virus
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container_title International journal of gynecology and obstetrics
container_volume 154
creator Nkwabong, Elie
Kengne, Berenis
Nkene Mawamba, Yvette
Sando, Zacharie
description Objective To study the influence of HIV status on the occurrence of cervical precancerous lesions (CPL). Methods This analytical cross‐sectional study was carried out between December 1, 2019 and May 31, 2020. All women with documented HIV status screened for CPL with biopsies performed were recruited. The main variables recorded included maternal age, educational level, number of sexual partners, age at first sexual intercourse, smoking, alcohol consumption, HIV status, CD4 count, and cervical biopsy result. Fisher exact test and Student's t test were used for comparison. A p value
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Methods This analytical cross‐sectional study was carried out between December 1, 2019 and May 31, 2020. All women with documented HIV status screened for CPL with biopsies performed were recruited. The main variables recorded included maternal age, educational level, number of sexual partners, age at first sexual intercourse, smoking, alcohol consumption, HIV status, CD4 count, and cervical biopsy result. Fisher exact test and Student's t test were used for comparison. A p value &lt;0.05 was considered statistically significant. Results Concerning women attending our screening units, CPL was more frequent among those living with HIV/AIDS (20/92; 21.7%) than among those not living with HIV/AIDS (29/290; 10.0%) (p = 0.004). As regards women living with HIV/AIDS, those with a CD4 count below 350/mL were more at risk of having a CPL (odds ratio [OR] 21.39, 95% confidence interval [CI] 5.60–81.56, p ˂ 0.001). High‐grade lesions (cervical intraepithelial neoplasia Stage 2 or 3) were more often found in women living with HIV/AIDS (OR 3.83, 95% CI 1.09–13.45, p = 0.033). Conclusion More attention should be paid to women living with HIV/AIDS, especially those with CD4 count less than 350/mL, who should be screened more often with biopsy frequently conducted if indicated. 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Methods This analytical cross‐sectional study was carried out between December 1, 2019 and May 31, 2020. All women with documented HIV status screened for CPL with biopsies performed were recruited. The main variables recorded included maternal age, educational level, number of sexual partners, age at first sexual intercourse, smoking, alcohol consumption, HIV status, CD4 count, and cervical biopsy result. Fisher exact test and Student's t test were used for comparison. A p value &lt;0.05 was considered statistically significant. Results Concerning women attending our screening units, CPL was more frequent among those living with HIV/AIDS (20/92; 21.7%) than among those not living with HIV/AIDS (29/290; 10.0%) (p = 0.004). As regards women living with HIV/AIDS, those with a CD4 count below 350/mL were more at risk of having a CPL (odds ratio [OR] 21.39, 95% confidence interval [CI] 5.60–81.56, p ˂ 0.001). High‐grade lesions (cervical intraepithelial neoplasia Stage 2 or 3) were more often found in women living with HIV/AIDS (OR 3.83, 95% CI 1.09–13.45, p = 0.033). Conclusion More attention should be paid to women living with HIV/AIDS, especially those with CD4 count less than 350/mL, who should be screened more often with biopsy frequently conducted if indicated. Synopsis High‐grade cervical precancerous lesions are more often observed among women living with HIV/AIDS, especially if CD4 count is less than 350/mL.</description><subject>CD4 count</subject><subject>cervical precancerous lesions</subject><subject>high‐grade lesions</subject><subject>human immunodeficiency virus</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PAjEQhhujEUQv_gCzR2Oy2M_d7tEQRQyRi56bbncqJfuBLYvh31sEPXqaw_vMk5kXoWuCxwRjeu9WH92YsIwVJ2hIZF6kjOfFKRrGEKc5LegAXYSwwhiTnJBzNGBMcC4lGaLXWWvrHloDSWeTzRKSZd_oNnFN07ddBdYZF9NdsnW-D0nXJgb81hldJ2sPRsdF38WghuC6NlyiM6vrAFfHOULvT49vk-d0vpjOJg_z1FAp431YFhloS5mE3DDDZVkYUVacZUJUosoNF6QsNcHWWkoFaA1YQ2ayKqeyqNgI3R68a9999hA2qnHBQF3rFuI5inKZE8HjtxG9O6DGdyF4sGrtXaP9ThGs9v2pfX_qp78I3xy9fdlA9Yf-FhYBcgC-XA27f1Rq9jJdHKTf3Bl8PA</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Nkwabong, Elie</creator><creator>Kengne, Berenis</creator><creator>Nkene Mawamba, Yvette</creator><creator>Sando, Zacharie</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202109</creationdate><title>Influence of the human immunodeficiency virus on cervical precancerous lesions</title><author>Nkwabong, Elie ; Kengne, Berenis ; Nkene Mawamba, Yvette ; Sando, Zacharie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2889-30896eaf238e7c3c48b9c5bd43655d5d7c451bba10fff225eaae0ae6c6d7289d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>CD4 count</topic><topic>cervical precancerous lesions</topic><topic>high‐grade lesions</topic><topic>human immunodeficiency virus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nkwabong, Elie</creatorcontrib><creatorcontrib>Kengne, Berenis</creatorcontrib><creatorcontrib>Nkene Mawamba, Yvette</creatorcontrib><creatorcontrib>Sando, Zacharie</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nkwabong, Elie</au><au>Kengne, Berenis</au><au>Nkene Mawamba, Yvette</au><au>Sando, Zacharie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of the human immunodeficiency virus on cervical precancerous lesions</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2021-09</date><risdate>2021</risdate><volume>154</volume><issue>3</issue><spage>540</spage><epage>543</epage><pages>540-543</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><abstract>Objective To study the influence of HIV status on the occurrence of cervical precancerous lesions (CPL). Methods This analytical cross‐sectional study was carried out between December 1, 2019 and May 31, 2020. All women with documented HIV status screened for CPL with biopsies performed were recruited. The main variables recorded included maternal age, educational level, number of sexual partners, age at first sexual intercourse, smoking, alcohol consumption, HIV status, CD4 count, and cervical biopsy result. Fisher exact test and Student's t test were used for comparison. A p value &lt;0.05 was considered statistically significant. Results Concerning women attending our screening units, CPL was more frequent among those living with HIV/AIDS (20/92; 21.7%) than among those not living with HIV/AIDS (29/290; 10.0%) (p = 0.004). As regards women living with HIV/AIDS, those with a CD4 count below 350/mL were more at risk of having a CPL (odds ratio [OR] 21.39, 95% confidence interval [CI] 5.60–81.56, p ˂ 0.001). High‐grade lesions (cervical intraepithelial neoplasia Stage 2 or 3) were more often found in women living with HIV/AIDS (OR 3.83, 95% CI 1.09–13.45, p = 0.033). Conclusion More attention should be paid to women living with HIV/AIDS, especially those with CD4 count less than 350/mL, who should be screened more often with biopsy frequently conducted if indicated. Synopsis High‐grade cervical precancerous lesions are more often observed among women living with HIV/AIDS, especially if CD4 count is less than 350/mL.</abstract><cop>United States</cop><pmid>33544881</pmid><doi>10.1002/ijgo.13639</doi><tpages>4</tpages></addata></record>
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subjects CD4 count
cervical precancerous lesions
high‐grade lesions
human immunodeficiency virus
title Influence of the human immunodeficiency virus on cervical precancerous lesions
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