The SNAG Domain of Insm1 Regulates Pancreatic Endocrine Cell Differentiation and Represses β- to δ-Cell Transdifferentiation

The allocation and specification of pancreatic endocrine lineages are tightly regulated by transcription factors. Disturbances in differentiation of these lineages contribute to the development of various metabolic diseases, including diabetes. The insulinoma-associated protein 1 ( ), which encodes...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2021-05, Vol.70 (5), p.1084-1097
Hauptverfasser:	Liang, Xuehua, Duan, Hualin, Mao, Yahui, Koestner, Ulrich, Wei, Yiqiu, Deng, Feng, Zhuang, Jingshen, Li, Huimin, Wang, Cunchuan, Hernandez-Miranda, Luis R, Tao, Weihua, Jia, Shiqi
Format:	Artikel
Sprache:	eng
Schlagworte:	Beta cells Cell differentiation Cell number Cellular biology Diabetes Diabetes mellitus Homeobox Insulinoma Metabolic disorders Mutants Mutation Neuroendocrine tumors Pancreas Transcription factors Zinc finger proteins
Online-Zugang:	Volltext
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