Preparation of exosomes encapsulated nanohydrogel for accelerating wound healing of diabetic rats by promoting angiogenesis
Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) were helpful for injury repair, but whether HUCMSCs-derived exosomes could be encapsulated in a novel nanohydrogel to regulate diabetic wound healing was unclear. Here, HUCMSCs-derived exosomes encapsulated in a bioactive sc...
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| Veröffentlicht in: | Materials Science & Engineering C 2021-01, Vol.120, p.111671-111671, Article 111671 |
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| creator | Zhang, Yiyao Zhang, Peng Gao, Xiuqiu Chang, Linna Chen, Zhenhua Mei, Xifan |
| description | Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) were helpful for injury repair, but whether HUCMSCs-derived exosomes could be encapsulated in a novel nanohydrogel to regulate diabetic wound healing was unclear. Here, HUCMSCs-derived exosomes encapsulated in a bioactive scaffold composed of polyvinyl alcohol (PVA)/alginate (Alg) nanohydrogel (exo@H) was applied to wound healing of diabetic rats. Results found that exo@H could facilitate the proliferation, migration and angiogenesis of HUVECs and sped up the process of diabetic wound healing. We confirmed that exo@H contributed to the expression of the molecules related to wound healing, including SMA, SR-B1 and CD31. Besides, we also found that exo@H up-regulated VEGF level via regulating ERK1/2 pathway. These data demonstrated that exo@H significantly accelerated healing of diabetic wounds in rats by promoting angiogenesis.
•Wound healing for diabetes is still a challenge.•Exosomes are found to be helpful for injury healing, however, low retention rate and sustained release after injection remain a challenge•Novel exosomes loaded nanohydrogel was prepared to accelerate wound healing of diabetic rats. |
| doi_str_mv | 10.1016/j.msec.2020.111671 |
| format | Article |
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•Wound healing for diabetes is still a challenge.•Exosomes are found to be helpful for injury healing, however, low retention rate and sustained release after injection remain a challenge•Novel exosomes loaded nanohydrogel was prepared to accelerate wound healing of diabetic rats.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2020.111671</identifier><identifier>PMID: 33545836</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alginate ; Alginates ; Alginic acid ; Angiogenesis ; Animals ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Experimental - therapy ; Diabetic wound healing ; Encapsulation ; Exosomes ; Materials science ; Mesenchymal Stem Cells ; Mesenchyme ; Nanohydrogel ; Polyvinyl alcohol ; PVA ; Rats ; Rodents ; Stem cell transplantation ; Stem cells ; Umbilical cord ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A ; Wound Healing</subject><ispartof>Materials Science & Engineering C, 2021-01, Vol.120, p.111671-111671, Article 111671</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Jan 2021</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-9ad9d2c7dcc907fcec97b1b1fa87b3dc48f39681cdb2869f45fbde32a20ca5413</citedby><cites>FETCH-LOGICAL-c384t-9ad9d2c7dcc907fcec97b1b1fa87b3dc48f39681cdb2869f45fbde32a20ca5413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.msec.2020.111671$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33545836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yiyao</creatorcontrib><creatorcontrib>Zhang, Peng</creatorcontrib><creatorcontrib>Gao, Xiuqiu</creatorcontrib><creatorcontrib>Chang, Linna</creatorcontrib><creatorcontrib>Chen, Zhenhua</creatorcontrib><creatorcontrib>Mei, Xifan</creatorcontrib><title>Preparation of exosomes encapsulated nanohydrogel for accelerating wound healing of diabetic rats by promoting angiogenesis</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) were helpful for injury repair, but whether HUCMSCs-derived exosomes could be encapsulated in a novel nanohydrogel to regulate diabetic wound healing was unclear. Here, HUCMSCs-derived exosomes encapsulated in a bioactive scaffold composed of polyvinyl alcohol (PVA)/alginate (Alg) nanohydrogel (exo@H) was applied to wound healing of diabetic rats. Results found that exo@H could facilitate the proliferation, migration and angiogenesis of HUVECs and sped up the process of diabetic wound healing. We confirmed that exo@H contributed to the expression of the molecules related to wound healing, including SMA, SR-B1 and CD31. Besides, we also found that exo@H up-regulated VEGF level via regulating ERK1/2 pathway. These data demonstrated that exo@H significantly accelerated healing of diabetic wounds in rats by promoting angiogenesis.
•Wound healing for diabetes is still a challenge.•Exosomes are found to be helpful for injury healing, however, low retention rate and sustained release after injection remain a challenge•Novel exosomes loaded nanohydrogel was prepared to accelerate wound healing of diabetic rats.</description><subject>Alginate</subject><subject>Alginates</subject><subject>Alginic acid</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - therapy</subject><subject>Diabetic wound healing</subject><subject>Encapsulation</subject><subject>Exosomes</subject><subject>Materials science</subject><subject>Mesenchymal Stem Cells</subject><subject>Mesenchyme</subject><subject>Nanohydrogel</subject><subject>Polyvinyl alcohol</subject><subject>PVA</subject><subject>Rats</subject><subject>Rodents</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Umbilical cord</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A</subject><subject>Wound Healing</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9rFDEchoNY7Lb6BTxIwIuX2ebfTBLwIkWtUKgHPYdM8pttlplkTWbUxS_fjFs9ePAUEp735SUPQi8p2VJCu6v9dirgtoyw-kBpJ-kTtKFK8oZQTZ-iDdFMNUJzeo4uStkT0iku2TN0znkrWsW7Dfr1OcPBZjuHFHEaMPxMJU1QMERnD2UZ7QweRxvT_dHntIMRDylj6xyMsMbiDv9IS_T4Huy43mqJD7aHOThcgYL7Iz7kNKXfrI27UFsilFCeo7PBjgVePJ6X6OuH91-ub5rbu4-frt_dNo4rMTfaeu2Zk945TeTgwGnZ054OVsmeeyfUwHWnqPM9U50eRDv0HjizjDjbCsov0ZtTb53xbYEymymUun-0EdJSDBNK0pYKoSr6-h90n5Yc67pKackYZ0RWip0ol1MpGQZzyGGy-WgoMasaszerGrOqMSc1NfTqsXrpJ_B_I39cVODtCYD6F98DZFNcqBrAhwxuNj6F__U_AE_2oqU</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Zhang, Yiyao</creator><creator>Zhang, Peng</creator><creator>Gao, Xiuqiu</creator><creator>Chang, Linna</creator><creator>Chen, Zhenhua</creator><creator>Mei, Xifan</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>202101</creationdate><title>Preparation of exosomes encapsulated nanohydrogel for accelerating wound healing of diabetic rats by promoting angiogenesis</title><author>Zhang, Yiyao ; Zhang, Peng ; Gao, Xiuqiu ; Chang, Linna ; Chen, Zhenhua ; Mei, Xifan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-9ad9d2c7dcc907fcec97b1b1fa87b3dc48f39681cdb2869f45fbde32a20ca5413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alginate</topic><topic>Alginates</topic><topic>Alginic acid</topic><topic>Angiogenesis</topic><topic>Animals</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - therapy</topic><topic>Diabetic wound healing</topic><topic>Encapsulation</topic><topic>Exosomes</topic><topic>Materials science</topic><topic>Mesenchymal Stem Cells</topic><topic>Mesenchyme</topic><topic>Nanohydrogel</topic><topic>Polyvinyl alcohol</topic><topic>PVA</topic><topic>Rats</topic><topic>Rodents</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Umbilical cord</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A</topic><topic>Wound Healing</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yiyao</creatorcontrib><creatorcontrib>Zhang, Peng</creatorcontrib><creatorcontrib>Gao, Xiuqiu</creatorcontrib><creatorcontrib>Chang, Linna</creatorcontrib><creatorcontrib>Chen, Zhenhua</creatorcontrib><creatorcontrib>Mei, Xifan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Materials Science & Engineering C</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yiyao</au><au>Zhang, Peng</au><au>Gao, Xiuqiu</au><au>Chang, Linna</au><au>Chen, Zhenhua</au><au>Mei, Xifan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of exosomes encapsulated nanohydrogel for accelerating wound healing of diabetic rats by promoting angiogenesis</atitle><jtitle>Materials Science & Engineering C</jtitle><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><date>2021-01</date><risdate>2021</risdate><volume>120</volume><spage>111671</spage><epage>111671</epage><pages>111671-111671</pages><artnum>111671</artnum><issn>0928-4931</issn><eissn>1873-0191</eissn><abstract>Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) were helpful for injury repair, but whether HUCMSCs-derived exosomes could be encapsulated in a novel nanohydrogel to regulate diabetic wound healing was unclear. Here, HUCMSCs-derived exosomes encapsulated in a bioactive scaffold composed of polyvinyl alcohol (PVA)/alginate (Alg) nanohydrogel (exo@H) was applied to wound healing of diabetic rats. Results found that exo@H could facilitate the proliferation, migration and angiogenesis of HUVECs and sped up the process of diabetic wound healing. We confirmed that exo@H contributed to the expression of the molecules related to wound healing, including SMA, SR-B1 and CD31. Besides, we also found that exo@H up-regulated VEGF level via regulating ERK1/2 pathway. These data demonstrated that exo@H significantly accelerated healing of diabetic wounds in rats by promoting angiogenesis.
•Wound healing for diabetes is still a challenge.•Exosomes are found to be helpful for injury healing, however, low retention rate and sustained release after injection remain a challenge•Novel exosomes loaded nanohydrogel was prepared to accelerate wound healing of diabetic rats.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33545836</pmid><doi>10.1016/j.msec.2020.111671</doi><tpages>1</tpages></addata></record> |
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| ispartof | Materials Science & Engineering C, 2021-01, Vol.120, p.111671-111671, Article 111671 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Alginate Alginates Alginic acid Angiogenesis Animals Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - therapy Diabetic wound healing Encapsulation Exosomes Materials science Mesenchymal Stem Cells Mesenchyme Nanohydrogel Polyvinyl alcohol PVA Rats Rodents Stem cell transplantation Stem cells Umbilical cord Vascular endothelial growth factor Vascular Endothelial Growth Factor A Wound Healing |
| title | Preparation of exosomes encapsulated nanohydrogel for accelerating wound healing of diabetic rats by promoting angiogenesis |
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