Facile synthesis of 1,4-oxazines by ruthenium-catalyzed tandem N-H insertion/cyclization of α-arylamino ketones and diazo pyruvates

Herein, we report an efficient strategy for the rapid construction of 1,4-oxazines starting from simple α-amino ketones and diazo pyruvates under mild reaction conditions. This transformation is efficiently catalyzed by RuCl 3 through a tandem N-H insertion/cyclization sequence via an enol formation...

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Veröffentlicht in:	Organic & biomolecular chemistry 2021-03, Vol.19 (8), p.1769-1772
Hauptverfasser:	Sajjad, Farrukh, Chen, Yanmei, Tian, Xue, Dong, Suzhen, Gopi Krishna Reddy, Alavala, Hu, Wenhao, Xing, Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Chemical synthesis Functional groups Insertion Ketones Nucleotide sequence Oxazine Pyruvates Ruthenium Ruthenium trichloride
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