Effects of ChREBP deficiency on adrenal lipogenesis and steroidogenesis

Carbohydrate response element-binding protein (ChREBP) is critical in the regulation of fatty acid and triglyceride synthesis in the liver. Interestingly, Chrebp−/− mice show reduced levels of plasma cholesterol, which is critical for steroid hormone synthesis in adrenal glands. Furthermore, Chrebp...

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Veröffentlicht in:	Journal of endocrinology 2021-03, Vol.248 (3), p.317-324
Hauptverfasser:	Takao, Ken, Iizuka, Katsumi, Liu, Yanyan, Sakurai, Teruaki, Kubota, Sodai, Kubota-Okamoto, Saki, Imaizumi, Toshinori, Takahashi, Yoshihiro, Rakhat, Yermek, Komori, Satoko, Hirose, Tokuyuki, Nonomura, Kenta, Kato, Takehiro, Mizuno, Masami, Suwa, Tetsuya, Horikawa, Yukio, Sone, Masakatsu, Yabe, Daisuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - metabolism Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - deficiency Cholesterol - blood Corticosterone - biosynthesis Endocrinology & Metabolism Life Sciences & Biomedicine Lipogenesis Male Mice Mice, Inbred C57BL Science & Technology
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