Evidence for Glucagon Secretion and Function Within the Human Gut

Glucagon is secreted by pancreatic α cells in response to hypoglycemia and increases hepatic glucose output through hepatic glucagon receptors (GCGRs). There is evidence supporting the notion of extrapancreatic glucagon but its source and physiological functions remain elusive. Intestinal tissue sam...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2021-04, Vol.162 (4), p.1
Hauptverfasser:	Sun, Emily W, Martin, Alyce M, de Fontgalland, Dayan, Sposato, Luigi, Rabbitt, Philippa, Hollington, Paul, Wattchow, David A, Colella, Alexander D, Chataway, Tim, Wewer Albrechtsen, Nicolai J, Spencer, Nick J, Young, Richard L, Keating, Damien J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Assaying Cell culture Cholesterol Circuits Dextrose Digestive system Endocrinology Enzyme-linked immunosorbent assay Enzymes Gastric motility Gastrointestinal tract GLP-1 receptor agonists Glucagon Glucagon-like peptide 1 Glucose Hypoglycemia Ileum Intestine Liver Mass spectrometry Mass spectroscopy Motility Mucosa Physiology Receptors Scientific imaging Sitagliptin Sodium-glucose cotransporter Tissues Type 2 diabetes
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