Angler Peptides: Macrocyclic Conjugates Inhibit p53:MDM2/X Interactions and Activate Apoptosis in Cancer Cells

Peptides are being developed as targeted anticancer drugs to modulate cytosolic protein–protein interactions involved in cancer progression. However, their use as therapeutics is often limited by their low cell membrane permeation and/or inability to reach cytosolic targets. Conjugation to cell pene...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ACS chemical biology 2021-02, Vol.16 (2), p.414-428
Hauptverfasser:	Philippe, Grégoire J.-B, Mittermeier, Anna, Lawrence, Nicole, Huang, Yen-Hua, Condon, Nicholas D, Loewer, Alexander, Craik, David J, Henriques, Sónia T
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!