Effect of selenium-enriched kiwifruit on body fat reduction and liver protection in hyperlipidaemic mice
This study aimed to investigate the effects and mechanism of selenium-enriched kiwifruit (Se-Kiwi) on lipid-lowering and liver protection in hyperlipidaemic mice induced by consuming a long-term high-fat diet. Selenium-enriched cultivation can significantly improve the contents of vitamins and funct...
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| Veröffentlicht in: | Food & function 2021-03, Vol.12 (5), p.244-257 |
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| creator | Zhang, Xiaoni Xia, Haidong Wang, Jie Leng, Ruyue Zhou, Xiaojing Gao, Qian He, Kan Liu, Dahai Huang, Bei |
| description | This study aimed to investigate the effects and mechanism of selenium-enriched kiwifruit (Se-Kiwi) on lipid-lowering and liver protection in hyperlipidaemic mice induced by consuming a long-term high-fat diet. Selenium-enriched cultivation can significantly improve the contents of vitamins and functional elements in kiwifruits, especially vitamin C, selenium, and manganese, thus enhancing the activity of antioxidant enzymes in Se-Kiwi. Se-Kiwi can significantly improve the activity of antioxidant enzymes in the liver of hyperlipidaemic mice, restore the liver morphology of mice close to normal, reduce the fat content in the liver, and inhibit the accumulation of abdominal fat cells. Meanwhile, the expression levels of inflammation-related factors (TNF-α and NF-κB) and lipid synthesis related genes (SREBP-1c and FAS) are inhibited at the gene transcription and protein expression levels, and the expression levels of energy expenditure related genes (PPAR-α and CPT1) are increased, resulting in lipid reductions and liver protection. In conclusion, our results indicate that the protective mechanism of Se-Kiwi on high-fat diet mice is associated with enhancing the activity of antioxidant enzymes, reducing the degree of the inflammatory reaction, inhibiting the fat synthesis, and accelerating body energy consumption.
This study aimed to investigate the effects and mechanism of selenium-enriched kiwifruit (Se-Kiwi) on lipid-lowering and liver protection in hyperlipidaemic mice induced by consuming a long-term high-fat diet. |
| doi_str_mv | 10.1039/d0fo02410d |
| format | Article |
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This study aimed to investigate the effects and mechanism of selenium-enriched kiwifruit (Se-Kiwi) on lipid-lowering and liver protection in hyperlipidaemic mice induced by consuming a long-term high-fat diet.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d0fo02410d</identifier><identifier>PMID: 33532813</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Actinidia ; Adipocytes ; Antioxidants ; Ascorbic acid ; Body fat ; Chemical synthesis ; Diet ; Energy consumption ; Energy expenditure ; Enrichment ; Enzymes ; Gene expression ; Genes ; High fat diet ; Inflammation ; Kiwifruit ; Lipids ; Liver ; Manganese ; Morphology ; NF-κB protein ; Peroxisome proliferator-activated receptors ; Selenium ; Sterol regulatory element-binding protein ; Transcription ; Tumor necrosis factor-α ; Vitamins</subject><ispartof>Food & function, 2021-03, Vol.12 (5), p.244-257</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-e1b5b24e446f39b8fe6fe6b182485c38cfcf209de003815d0265822ad235b2823</citedby><cites>FETCH-LOGICAL-c337t-e1b5b24e446f39b8fe6fe6b182485c38cfcf209de003815d0265822ad235b2823</cites><orcidid>0000-0002-3385-7129 ; 0000-0002-2078-4063</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33532813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Xiaoni</creatorcontrib><creatorcontrib>Xia, Haidong</creatorcontrib><creatorcontrib>Wang, Jie</creatorcontrib><creatorcontrib>Leng, Ruyue</creatorcontrib><creatorcontrib>Zhou, Xiaojing</creatorcontrib><creatorcontrib>Gao, Qian</creatorcontrib><creatorcontrib>He, Kan</creatorcontrib><creatorcontrib>Liu, Dahai</creatorcontrib><creatorcontrib>Huang, Bei</creatorcontrib><title>Effect of selenium-enriched kiwifruit on body fat reduction and liver protection in hyperlipidaemic mice</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>This study aimed to investigate the effects and mechanism of selenium-enriched kiwifruit (Se-Kiwi) on lipid-lowering and liver protection in hyperlipidaemic mice induced by consuming a long-term high-fat diet. Selenium-enriched cultivation can significantly improve the contents of vitamins and functional elements in kiwifruits, especially vitamin C, selenium, and manganese, thus enhancing the activity of antioxidant enzymes in Se-Kiwi. Se-Kiwi can significantly improve the activity of antioxidant enzymes in the liver of hyperlipidaemic mice, restore the liver morphology of mice close to normal, reduce the fat content in the liver, and inhibit the accumulation of abdominal fat cells. Meanwhile, the expression levels of inflammation-related factors (TNF-α and NF-κB) and lipid synthesis related genes (SREBP-1c and FAS) are inhibited at the gene transcription and protein expression levels, and the expression levels of energy expenditure related genes (PPAR-α and CPT1) are increased, resulting in lipid reductions and liver protection. In conclusion, our results indicate that the protective mechanism of Se-Kiwi on high-fat diet mice is associated with enhancing the activity of antioxidant enzymes, reducing the degree of the inflammatory reaction, inhibiting the fat synthesis, and accelerating body energy consumption.
This study aimed to investigate the effects and mechanism of selenium-enriched kiwifruit (Se-Kiwi) on lipid-lowering and liver protection in hyperlipidaemic mice induced by consuming a long-term high-fat diet.</description><subject>Actinidia</subject><subject>Adipocytes</subject><subject>Antioxidants</subject><subject>Ascorbic acid</subject><subject>Body fat</subject><subject>Chemical synthesis</subject><subject>Diet</subject><subject>Energy consumption</subject><subject>Energy expenditure</subject><subject>Enrichment</subject><subject>Enzymes</subject><subject>Gene expression</subject><subject>Genes</subject><subject>High fat diet</subject><subject>Inflammation</subject><subject>Kiwifruit</subject><subject>Lipids</subject><subject>Liver</subject><subject>Manganese</subject><subject>Morphology</subject><subject>NF-κB protein</subject><subject>Peroxisome proliferator-activated receptors</subject><subject>Selenium</subject><subject>Sterol regulatory element-binding protein</subject><subject>Transcription</subject><subject>Tumor necrosis factor-α</subject><subject>Vitamins</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkctLxDAQxoMorqxevCsBLyJU82ja5CjrExa8KHgrbTJho32ZtMr-90brKhgmZJj55WOSD6FDSs4p4erCENsRllJittAeIylLMkGetzd5qrIZOgjhhcTFlZJK7qIZ54IzSfkeWl1bC3rAncUBamjd2CTQeqdXYPCr-3DWjy62W1x1Zo1tOWAPZtSDi6WyNbh27-Bx77sBpqJr8Wrdg69d70wJjdM4bthHO7asAxz8nHP0dHP9uLhLlg-394vLZaI5z4cEaCUqlkKaZparSlrIYlRUslQKzaW22jKiDMTXSCoMYZmQjJWG8XhPMj5Hp5NuHOlthDAUjQsa6rpsoRtDEXUyKnKe5xE9-Ye-dKNv43QFE4QyKhRXkTqbKO27EDzYoveuKf26oKT4sqC4IjcP3xZcRfj4R3KsGjC_6ObDI3A0AT7o3-6fh_wT7pmKsg</recordid><startdate>20210315</startdate><enddate>20210315</enddate><creator>Zhang, Xiaoni</creator><creator>Xia, Haidong</creator><creator>Wang, Jie</creator><creator>Leng, Ruyue</creator><creator>Zhou, Xiaojing</creator><creator>Gao, Qian</creator><creator>He, Kan</creator><creator>Liu, Dahai</creator><creator>Huang, Bei</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3385-7129</orcidid><orcidid>https://orcid.org/0000-0002-2078-4063</orcidid></search><sort><creationdate>20210315</creationdate><title>Effect of selenium-enriched kiwifruit on body fat reduction and liver protection in hyperlipidaemic mice</title><author>Zhang, Xiaoni ; Xia, Haidong ; Wang, Jie ; Leng, Ruyue ; Zhou, Xiaojing ; Gao, Qian ; He, Kan ; Liu, Dahai ; Huang, Bei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-e1b5b24e446f39b8fe6fe6b182485c38cfcf209de003815d0265822ad235b2823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Actinidia</topic><topic>Adipocytes</topic><topic>Antioxidants</topic><topic>Ascorbic acid</topic><topic>Body fat</topic><topic>Chemical synthesis</topic><topic>Diet</topic><topic>Energy consumption</topic><topic>Energy expenditure</topic><topic>Enrichment</topic><topic>Enzymes</topic><topic>Gene expression</topic><topic>Genes</topic><topic>High fat diet</topic><topic>Inflammation</topic><topic>Kiwifruit</topic><topic>Lipids</topic><topic>Liver</topic><topic>Manganese</topic><topic>Morphology</topic><topic>NF-κB protein</topic><topic>Peroxisome proliferator-activated receptors</topic><topic>Selenium</topic><topic>Sterol regulatory element-binding protein</topic><topic>Transcription</topic><topic>Tumor necrosis factor-α</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xiaoni</creatorcontrib><creatorcontrib>Xia, Haidong</creatorcontrib><creatorcontrib>Wang, Jie</creatorcontrib><creatorcontrib>Leng, Ruyue</creatorcontrib><creatorcontrib>Zhou, Xiaojing</creatorcontrib><creatorcontrib>Gao, Qian</creatorcontrib><creatorcontrib>He, Kan</creatorcontrib><creatorcontrib>Liu, Dahai</creatorcontrib><creatorcontrib>Huang, Bei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xiaoni</au><au>Xia, Haidong</au><au>Wang, Jie</au><au>Leng, Ruyue</au><au>Zhou, Xiaojing</au><au>Gao, Qian</au><au>He, Kan</au><au>Liu, Dahai</au><au>Huang, Bei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of selenium-enriched kiwifruit on body fat reduction and liver protection in hyperlipidaemic mice</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2021-03-15</date><risdate>2021</risdate><volume>12</volume><issue>5</issue><spage>244</spage><epage>257</epage><pages>244-257</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>This study aimed to investigate the effects and mechanism of selenium-enriched kiwifruit (Se-Kiwi) on lipid-lowering and liver protection in hyperlipidaemic mice induced by consuming a long-term high-fat diet. Selenium-enriched cultivation can significantly improve the contents of vitamins and functional elements in kiwifruits, especially vitamin C, selenium, and manganese, thus enhancing the activity of antioxidant enzymes in Se-Kiwi. Se-Kiwi can significantly improve the activity of antioxidant enzymes in the liver of hyperlipidaemic mice, restore the liver morphology of mice close to normal, reduce the fat content in the liver, and inhibit the accumulation of abdominal fat cells. Meanwhile, the expression levels of inflammation-related factors (TNF-α and NF-κB) and lipid synthesis related genes (SREBP-1c and FAS) are inhibited at the gene transcription and protein expression levels, and the expression levels of energy expenditure related genes (PPAR-α and CPT1) are increased, resulting in lipid reductions and liver protection. In conclusion, our results indicate that the protective mechanism of Se-Kiwi on high-fat diet mice is associated with enhancing the activity of antioxidant enzymes, reducing the degree of the inflammatory reaction, inhibiting the fat synthesis, and accelerating body energy consumption.
This study aimed to investigate the effects and mechanism of selenium-enriched kiwifruit (Se-Kiwi) on lipid-lowering and liver protection in hyperlipidaemic mice induced by consuming a long-term high-fat diet.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>33532813</pmid><doi>10.1039/d0fo02410d</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-3385-7129</orcidid><orcidid>https://orcid.org/0000-0002-2078-4063</orcidid></addata></record> |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Actinidia Adipocytes Antioxidants Ascorbic acid Body fat Chemical synthesis Diet Energy consumption Energy expenditure Enrichment Enzymes Gene expression Genes High fat diet Inflammation Kiwifruit Lipids Liver Manganese Morphology NF-κB protein Peroxisome proliferator-activated receptors Selenium Sterol regulatory element-binding protein Transcription Tumor necrosis factor-α Vitamins |
| title | Effect of selenium-enriched kiwifruit on body fat reduction and liver protection in hyperlipidaemic mice |
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