The Effect of Primary Surgery in Patients with De Novo Stage IV Breast Cancer with Bone Metastasis Only (Protocol BOMET MF 14-01): A Multi-Center, Prospective Registry Study
Background More evidence shows that primary surgery for de novo metastatic breast cancer (BC) prolongs overall survival (OS) in selected cases. The aim of this study was to evaluate the role of locoregional treatment (LRT) in BC patients with de novo stage IV bone only metastasis (BOM). Methods The...
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| Veröffentlicht in: | Annals of surgical oncology 2021-09, Vol.28 (9), p.5048-5057 |
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| creator | Soran, Atilla Dogan, Lutfi Isik, Arda Ozbas, Serdar Trabulus, Didem Can Demirci, Umut Karanlik, Hasan Soyder, Aykut Dag, Ahmet Bilici, Ahmet Dogan, Mutlu Koksal, Hande Sendur, Mehmet Ali Nahit Gulcelik, Mehmet Ali Maralcan, Gokturk Cabioglu, Neslihan Yeniay, Levent Utkan, Zafer Simsek, Turgay Karadurmus, Nuri Daglar, Gul Yildiz, Birol Uras, Cihan Tukenmez, Mustafa Yildirim, Ahmet Kutun, Suat Ozaslan, Cihangir Karaman, Niyazi Akcay, Müfide Nuran Toktas, Osman Sezgin, Efe |
| description | Background
More evidence shows that primary surgery for de novo metastatic breast cancer (BC) prolongs overall survival (OS) in selected cases. The aim of this study was to evaluate the role of locoregional treatment (LRT) in BC patients with de novo stage IV bone only metastasis (BOM).
Methods
The prospective, multicenter registry study BOMET MF14-01 was initiated in May 2014. Patients with de novo stage IV BOM BC were divided into two groups: those receiving systemic treatment (ST group) and those receiving LRT (LRT group). Patients who received LRT were further divided into two groups: ST after LRT (LRT + ST group) and ST before LRT (ST + LRT group).
Results
We included 505 patients in this study; 240 (47.5%) patients in the ST group and 265 (52.5%) in the LRT group. One hundred and thirteen patients (26.3%) died in the 34-month median follow-up, 85 (35.4%) in the ST group and 28 (10.5%) in LRT group. Local progression was observed in 39 (16.2%) of the patients in the ST group and 18 (6.7%) in the LRT group (
p
= 0.001). Hazard of death was 60% lower in the LRT group compared with the ST group (HR 0.40, 95% CI 0.30–0.54,
p
< 0.0001).
Conclusion
In this prospectively maintained registry study, we found that LRT prolonged survival and decreased locoregional recurrence in the median 3-year follow-up. Timing of primary breast surgery either at diagnosis or after ST provided a survival benefit similar to ST alone in de novo stage IV BOM BC patients. |
| doi_str_mv | 10.1245/s10434-021-09621-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2486155784</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2486155784</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-dd4fd1a03e55a496283280573ba1b7848ba3a491195f1927e6fc81f443cb3d633</originalsourceid><addsrcrecordid>eNp9UcFu1DAQjRCIlsIPcEAjcSkSATu2E4dbd9lCpS67ogtXy0km21TZeLGdov0o_pEpKSBx4OKxZt68eTMvSZ5z9oZnUr0NnEkhU5bxlJU5vfpBcswVpWSu-UP6s1ynZZaro-RJCDeM8UIw9Tg5EkKJTBf6OPmxuUZYtC3WEVwLa9_trD_A1ei3SLEbYG1jh0MM8L2L1_Ae4ZO7dXAV7Rbh4ivMPNoQYW6HGv2EmbkBYYmR8jZ0AVZDf4DTtXfR1a6H2Wq52MDyHDhp56_ewRksxz526ZzGoH9NIlzYk6DuFuEzbrsQ7xTFsTk8TR61tg_47D6eJF_OF5v5x_Ry9eFifnaZ1qJQMW0a2TbcMoFKWUmn0bQtU4WoLK8KLXVlBeU5L1XLy6zAvK01b6UUdSWaXIiT5HTi3Xv3bcQQza4LNfa9HdCNwWRS51wpoiLoy3-gN270A6kzmVIlz5nIGKGyCVXTbsFja_bTpQ1n5s5MM5lpyEzzy0yjqenFPfVY7bD50_LbPQKICRCoNJBhf2f_h_Ynlaunrw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2559160320</pqid></control><display><type>article</type><title>The Effect of Primary Surgery in Patients with De Novo Stage IV Breast Cancer with Bone Metastasis Only (Protocol BOMET MF 14-01): A Multi-Center, Prospective Registry Study</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Soran, Atilla ; Dogan, Lutfi ; Isik, Arda ; Ozbas, Serdar ; Trabulus, Didem Can ; Demirci, Umut ; Karanlik, Hasan ; Soyder, Aykut ; Dag, Ahmet ; Bilici, Ahmet ; Dogan, Mutlu ; Koksal, Hande ; Sendur, Mehmet Ali Nahit ; Gulcelik, Mehmet Ali ; Maralcan, Gokturk ; Cabioglu, Neslihan ; Yeniay, Levent ; Utkan, Zafer ; Simsek, Turgay ; Karadurmus, Nuri ; Daglar, Gul ; Yildiz, Birol ; Uras, Cihan ; Tukenmez, Mustafa ; Yildirim, Ahmet ; Kutun, Suat ; Ozaslan, Cihangir ; Karaman, Niyazi ; Akcay, Müfide Nuran ; Toktas, Osman ; Sezgin, Efe</creator><creatorcontrib>Soran, Atilla ; Dogan, Lutfi ; Isik, Arda ; Ozbas, Serdar ; Trabulus, Didem Can ; Demirci, Umut ; Karanlik, Hasan ; Soyder, Aykut ; Dag, Ahmet ; Bilici, Ahmet ; Dogan, Mutlu ; Koksal, Hande ; Sendur, Mehmet Ali Nahit ; Gulcelik, Mehmet Ali ; Maralcan, Gokturk ; Cabioglu, Neslihan ; Yeniay, Levent ; Utkan, Zafer ; Simsek, Turgay ; Karadurmus, Nuri ; Daglar, Gul ; Yildiz, Birol ; Uras, Cihan ; Tukenmez, Mustafa ; Yildirim, Ahmet ; Kutun, Suat ; Ozaslan, Cihangir ; Karaman, Niyazi ; Akcay, Müfide Nuran ; Toktas, Osman ; Sezgin, Efe</creatorcontrib><description>Background
More evidence shows that primary surgery for de novo metastatic breast cancer (BC) prolongs overall survival (OS) in selected cases. The aim of this study was to evaluate the role of locoregional treatment (LRT) in BC patients with de novo stage IV bone only metastasis (BOM).
Methods
The prospective, multicenter registry study BOMET MF14-01 was initiated in May 2014. Patients with de novo stage IV BOM BC were divided into two groups: those receiving systemic treatment (ST group) and those receiving LRT (LRT group). Patients who received LRT were further divided into two groups: ST after LRT (LRT + ST group) and ST before LRT (ST + LRT group).
Results
We included 505 patients in this study; 240 (47.5%) patients in the ST group and 265 (52.5%) in the LRT group. One hundred and thirteen patients (26.3%) died in the 34-month median follow-up, 85 (35.4%) in the ST group and 28 (10.5%) in LRT group. Local progression was observed in 39 (16.2%) of the patients in the ST group and 18 (6.7%) in the LRT group (
p
= 0.001). Hazard of death was 60% lower in the LRT group compared with the ST group (HR 0.40, 95% CI 0.30–0.54,
p
< 0.0001).
Conclusion
In this prospectively maintained registry study, we found that LRT prolonged survival and decreased locoregional recurrence in the median 3-year follow-up. Timing of primary breast surgery either at diagnosis or after ST provided a survival benefit similar to ST alone in de novo stage IV BOM BC patients.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-021-09621-8</identifier><identifier>PMID: 33532878</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Bone cancer ; Bone surgery ; Breast cancer ; Breast Neoplasms - surgery ; Breast Oncology ; Breast surgery ; Female ; Humans ; Mastectomy ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Multicenter Studies as Topic ; Neoplasm Metastasis ; Neoplasm Recurrence, Local - surgery ; Oncology ; Patients ; Registries ; Retrospective Studies ; Surgery ; Surgical Oncology ; Survival ; Survival Rate</subject><ispartof>Annals of surgical oncology, 2021-09, Vol.28 (9), p.5048-5057</ispartof><rights>Society of Surgical Oncology 2021</rights><rights>2021. Society of Surgical Oncology.</rights><rights>Society of Surgical Oncology 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-dd4fd1a03e55a496283280573ba1b7848ba3a491195f1927e6fc81f443cb3d633</citedby><cites>FETCH-LOGICAL-c375t-dd4fd1a03e55a496283280573ba1b7848ba3a491195f1927e6fc81f443cb3d633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-021-09621-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-021-09621-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33532878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soran, Atilla</creatorcontrib><creatorcontrib>Dogan, Lutfi</creatorcontrib><creatorcontrib>Isik, Arda</creatorcontrib><creatorcontrib>Ozbas, Serdar</creatorcontrib><creatorcontrib>Trabulus, Didem Can</creatorcontrib><creatorcontrib>Demirci, Umut</creatorcontrib><creatorcontrib>Karanlik, Hasan</creatorcontrib><creatorcontrib>Soyder, Aykut</creatorcontrib><creatorcontrib>Dag, Ahmet</creatorcontrib><creatorcontrib>Bilici, Ahmet</creatorcontrib><creatorcontrib>Dogan, Mutlu</creatorcontrib><creatorcontrib>Koksal, Hande</creatorcontrib><creatorcontrib>Sendur, Mehmet Ali Nahit</creatorcontrib><creatorcontrib>Gulcelik, Mehmet Ali</creatorcontrib><creatorcontrib>Maralcan, Gokturk</creatorcontrib><creatorcontrib>Cabioglu, Neslihan</creatorcontrib><creatorcontrib>Yeniay, Levent</creatorcontrib><creatorcontrib>Utkan, Zafer</creatorcontrib><creatorcontrib>Simsek, Turgay</creatorcontrib><creatorcontrib>Karadurmus, Nuri</creatorcontrib><creatorcontrib>Daglar, Gul</creatorcontrib><creatorcontrib>Yildiz, Birol</creatorcontrib><creatorcontrib>Uras, Cihan</creatorcontrib><creatorcontrib>Tukenmez, Mustafa</creatorcontrib><creatorcontrib>Yildirim, Ahmet</creatorcontrib><creatorcontrib>Kutun, Suat</creatorcontrib><creatorcontrib>Ozaslan, Cihangir</creatorcontrib><creatorcontrib>Karaman, Niyazi</creatorcontrib><creatorcontrib>Akcay, Müfide Nuran</creatorcontrib><creatorcontrib>Toktas, Osman</creatorcontrib><creatorcontrib>Sezgin, Efe</creatorcontrib><title>The Effect of Primary Surgery in Patients with De Novo Stage IV Breast Cancer with Bone Metastasis Only (Protocol BOMET MF 14-01): A Multi-Center, Prospective Registry Study</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
More evidence shows that primary surgery for de novo metastatic breast cancer (BC) prolongs overall survival (OS) in selected cases. The aim of this study was to evaluate the role of locoregional treatment (LRT) in BC patients with de novo stage IV bone only metastasis (BOM).
Methods
The prospective, multicenter registry study BOMET MF14-01 was initiated in May 2014. Patients with de novo stage IV BOM BC were divided into two groups: those receiving systemic treatment (ST group) and those receiving LRT (LRT group). Patients who received LRT were further divided into two groups: ST after LRT (LRT + ST group) and ST before LRT (ST + LRT group).
Results
We included 505 patients in this study; 240 (47.5%) patients in the ST group and 265 (52.5%) in the LRT group. One hundred and thirteen patients (26.3%) died in the 34-month median follow-up, 85 (35.4%) in the ST group and 28 (10.5%) in LRT group. Local progression was observed in 39 (16.2%) of the patients in the ST group and 18 (6.7%) in the LRT group (
p
= 0.001). Hazard of death was 60% lower in the LRT group compared with the ST group (HR 0.40, 95% CI 0.30–0.54,
p
< 0.0001).
Conclusion
In this prospectively maintained registry study, we found that LRT prolonged survival and decreased locoregional recurrence in the median 3-year follow-up. Timing of primary breast surgery either at diagnosis or after ST provided a survival benefit similar to ST alone in de novo stage IV BOM BC patients.</description><subject>Bone cancer</subject><subject>Bone surgery</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - surgery</subject><subject>Breast Oncology</subject><subject>Breast surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Mastectomy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Multicenter Studies as Topic</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Oncology</subject><subject>Patients</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival</subject><subject>Survival Rate</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9UcFu1DAQjRCIlsIPcEAjcSkSATu2E4dbd9lCpS67ogtXy0km21TZeLGdov0o_pEpKSBx4OKxZt68eTMvSZ5z9oZnUr0NnEkhU5bxlJU5vfpBcswVpWSu-UP6s1ynZZaro-RJCDeM8UIw9Tg5EkKJTBf6OPmxuUZYtC3WEVwLa9_trD_A1ei3SLEbYG1jh0MM8L2L1_Ae4ZO7dXAV7Rbh4ivMPNoQYW6HGv2EmbkBYYmR8jZ0AVZDf4DTtXfR1a6H2Wq52MDyHDhp56_ewRksxz526ZzGoH9NIlzYk6DuFuEzbrsQ7xTFsTk8TR61tg_47D6eJF_OF5v5x_Ry9eFifnaZ1qJQMW0a2TbcMoFKWUmn0bQtU4WoLK8KLXVlBeU5L1XLy6zAvK01b6UUdSWaXIiT5HTi3Xv3bcQQza4LNfa9HdCNwWRS51wpoiLoy3-gN270A6kzmVIlz5nIGKGyCVXTbsFja_bTpQ1n5s5MM5lpyEzzy0yjqenFPfVY7bD50_LbPQKICRCoNJBhf2f_h_Ynlaunrw</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Soran, Atilla</creator><creator>Dogan, Lutfi</creator><creator>Isik, Arda</creator><creator>Ozbas, Serdar</creator><creator>Trabulus, Didem Can</creator><creator>Demirci, Umut</creator><creator>Karanlik, Hasan</creator><creator>Soyder, Aykut</creator><creator>Dag, Ahmet</creator><creator>Bilici, Ahmet</creator><creator>Dogan, Mutlu</creator><creator>Koksal, Hande</creator><creator>Sendur, Mehmet Ali Nahit</creator><creator>Gulcelik, Mehmet Ali</creator><creator>Maralcan, Gokturk</creator><creator>Cabioglu, Neslihan</creator><creator>Yeniay, Levent</creator><creator>Utkan, Zafer</creator><creator>Simsek, Turgay</creator><creator>Karadurmus, Nuri</creator><creator>Daglar, Gul</creator><creator>Yildiz, Birol</creator><creator>Uras, Cihan</creator><creator>Tukenmez, Mustafa</creator><creator>Yildirim, Ahmet</creator><creator>Kutun, Suat</creator><creator>Ozaslan, Cihangir</creator><creator>Karaman, Niyazi</creator><creator>Akcay, Müfide Nuran</creator><creator>Toktas, Osman</creator><creator>Sezgin, Efe</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20210901</creationdate><title>The Effect of Primary Surgery in Patients with De Novo Stage IV Breast Cancer with Bone Metastasis Only (Protocol BOMET MF 14-01): A Multi-Center, Prospective Registry Study</title><author>Soran, Atilla ; Dogan, Lutfi ; Isik, Arda ; Ozbas, Serdar ; Trabulus, Didem Can ; Demirci, Umut ; Karanlik, Hasan ; Soyder, Aykut ; Dag, Ahmet ; Bilici, Ahmet ; Dogan, Mutlu ; Koksal, Hande ; Sendur, Mehmet Ali Nahit ; Gulcelik, Mehmet Ali ; Maralcan, Gokturk ; Cabioglu, Neslihan ; Yeniay, Levent ; Utkan, Zafer ; Simsek, Turgay ; Karadurmus, Nuri ; Daglar, Gul ; Yildiz, Birol ; Uras, Cihan ; Tukenmez, Mustafa ; Yildirim, Ahmet ; Kutun, Suat ; Ozaslan, Cihangir ; Karaman, Niyazi ; Akcay, Müfide Nuran ; Toktas, Osman ; Sezgin, Efe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-dd4fd1a03e55a496283280573ba1b7848ba3a491195f1927e6fc81f443cb3d633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bone cancer</topic><topic>Bone surgery</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - surgery</topic><topic>Breast Oncology</topic><topic>Breast surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Mastectomy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Multicenter Studies as Topic</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Oncology</topic><topic>Patients</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soran, Atilla</creatorcontrib><creatorcontrib>Dogan, Lutfi</creatorcontrib><creatorcontrib>Isik, Arda</creatorcontrib><creatorcontrib>Ozbas, Serdar</creatorcontrib><creatorcontrib>Trabulus, Didem Can</creatorcontrib><creatorcontrib>Demirci, Umut</creatorcontrib><creatorcontrib>Karanlik, Hasan</creatorcontrib><creatorcontrib>Soyder, Aykut</creatorcontrib><creatorcontrib>Dag, Ahmet</creatorcontrib><creatorcontrib>Bilici, Ahmet</creatorcontrib><creatorcontrib>Dogan, Mutlu</creatorcontrib><creatorcontrib>Koksal, Hande</creatorcontrib><creatorcontrib>Sendur, Mehmet Ali Nahit</creatorcontrib><creatorcontrib>Gulcelik, Mehmet Ali</creatorcontrib><creatorcontrib>Maralcan, Gokturk</creatorcontrib><creatorcontrib>Cabioglu, Neslihan</creatorcontrib><creatorcontrib>Yeniay, Levent</creatorcontrib><creatorcontrib>Utkan, Zafer</creatorcontrib><creatorcontrib>Simsek, Turgay</creatorcontrib><creatorcontrib>Karadurmus, Nuri</creatorcontrib><creatorcontrib>Daglar, Gul</creatorcontrib><creatorcontrib>Yildiz, Birol</creatorcontrib><creatorcontrib>Uras, Cihan</creatorcontrib><creatorcontrib>Tukenmez, Mustafa</creatorcontrib><creatorcontrib>Yildirim, Ahmet</creatorcontrib><creatorcontrib>Kutun, Suat</creatorcontrib><creatorcontrib>Ozaslan, Cihangir</creatorcontrib><creatorcontrib>Karaman, Niyazi</creatorcontrib><creatorcontrib>Akcay, Müfide Nuran</creatorcontrib><creatorcontrib>Toktas, Osman</creatorcontrib><creatorcontrib>Sezgin, Efe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soran, Atilla</au><au>Dogan, Lutfi</au><au>Isik, Arda</au><au>Ozbas, Serdar</au><au>Trabulus, Didem Can</au><au>Demirci, Umut</au><au>Karanlik, Hasan</au><au>Soyder, Aykut</au><au>Dag, Ahmet</au><au>Bilici, Ahmet</au><au>Dogan, Mutlu</au><au>Koksal, Hande</au><au>Sendur, Mehmet Ali Nahit</au><au>Gulcelik, Mehmet Ali</au><au>Maralcan, Gokturk</au><au>Cabioglu, Neslihan</au><au>Yeniay, Levent</au><au>Utkan, Zafer</au><au>Simsek, Turgay</au><au>Karadurmus, Nuri</au><au>Daglar, Gul</au><au>Yildiz, Birol</au><au>Uras, Cihan</au><au>Tukenmez, Mustafa</au><au>Yildirim, Ahmet</au><au>Kutun, Suat</au><au>Ozaslan, Cihangir</au><au>Karaman, Niyazi</au><au>Akcay, Müfide Nuran</au><au>Toktas, Osman</au><au>Sezgin, Efe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Primary Surgery in Patients with De Novo Stage IV Breast Cancer with Bone Metastasis Only (Protocol BOMET MF 14-01): A Multi-Center, Prospective Registry Study</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>28</volume><issue>9</issue><spage>5048</spage><epage>5057</epage><pages>5048-5057</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
More evidence shows that primary surgery for de novo metastatic breast cancer (BC) prolongs overall survival (OS) in selected cases. The aim of this study was to evaluate the role of locoregional treatment (LRT) in BC patients with de novo stage IV bone only metastasis (BOM).
Methods
The prospective, multicenter registry study BOMET MF14-01 was initiated in May 2014. Patients with de novo stage IV BOM BC were divided into two groups: those receiving systemic treatment (ST group) and those receiving LRT (LRT group). Patients who received LRT were further divided into two groups: ST after LRT (LRT + ST group) and ST before LRT (ST + LRT group).
Results
We included 505 patients in this study; 240 (47.5%) patients in the ST group and 265 (52.5%) in the LRT group. One hundred and thirteen patients (26.3%) died in the 34-month median follow-up, 85 (35.4%) in the ST group and 28 (10.5%) in LRT group. Local progression was observed in 39 (16.2%) of the patients in the ST group and 18 (6.7%) in the LRT group (
p
= 0.001). Hazard of death was 60% lower in the LRT group compared with the ST group (HR 0.40, 95% CI 0.30–0.54,
p
< 0.0001).
Conclusion
In this prospectively maintained registry study, we found that LRT prolonged survival and decreased locoregional recurrence in the median 3-year follow-up. Timing of primary breast surgery either at diagnosis or after ST provided a survival benefit similar to ST alone in de novo stage IV BOM BC patients.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33532878</pmid><doi>10.1245/s10434-021-09621-8</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2021-09, Vol.28 (9), p.5048-5057 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2486155784 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Bone cancer Bone surgery Breast cancer Breast Neoplasms - surgery Breast Oncology Breast surgery Female Humans Mastectomy Medicine Medicine & Public Health Metastases Metastasis Multicenter Studies as Topic Neoplasm Metastasis Neoplasm Recurrence, Local - surgery Oncology Patients Registries Retrospective Studies Surgery Surgical Oncology Survival Survival Rate |
| title | The Effect of Primary Surgery in Patients with De Novo Stage IV Breast Cancer with Bone Metastasis Only (Protocol BOMET MF 14-01): A Multi-Center, Prospective Registry Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T07%3A14%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Effect%20of%20Primary%20Surgery%20in%20Patients%20with%20De%20Novo%20Stage%20IV%20Breast%20Cancer%20with%20Bone%20Metastasis%20Only%20(Protocol%20BOMET%20MF%2014-01):%20A%20Multi-Center,%20Prospective%20Registry%20Study&rft.jtitle=Annals%20of%20surgical%20oncology&rft.au=Soran,%20Atilla&rft.date=2021-09-01&rft.volume=28&rft.issue=9&rft.spage=5048&rft.epage=5057&rft.pages=5048-5057&rft.issn=1068-9265&rft.eissn=1534-4681&rft_id=info:doi/10.1245/s10434-021-09621-8&rft_dat=%3Cproquest_cross%3E2486155784%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2559160320&rft_id=info:pmid/33532878&rfr_iscdi=true |