MCRT, a multifunctional ligand of opioid and neuropeptide FF receptors, attenuates neuropathic pain in spared nerve injury model

Chimeric peptide MCRT (YPFPFRTic‐NH2) was a multifunctional ligand of opioid and neuropeptide FF (NPFF) receptors and reported to be potentially antalgic in acute tail‐flick test. Here, we developed spared nerve injury (SNI) model to explore its efficacy in chronic neuropathic pain. Analgesic tolera...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2021-06, Vol.128 (6), p.731-740
Hauptverfasser:	He, Chunbo, Wang, Xiaoli, Zhang, Jing, Wang, Hao, Zhao, Yaofeng, Shah, Jagat Narayan, Ma, Chan, Li, Hailan, Su, Wenting, Zhang, Zhe, Chen, Shasha, Zhou, Lanxia, Dong, Shouliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analgesics anti‐allodynia Constipation Ligands Morphine multifunctional ligand Narcotics neuropathic pain Neuropeptides opioid Opioid receptors (type delta) Opioid receptors (type mu) Pain Pain perception Peripheral neuropathy Receptors topical application
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