Combined application of geranylgeranylacetone and amelogenin promotes angiogenesis and wound healing in human periodontal ligament cells

Amelogenin directly binds to glucose‐regulated protein 78 (Grp78). Cell migration activity is expected to increase when human periodontal ligament cells (hPDLCs) overexpressing Grp78 are treated with amelogenin. Geranylgeranylacetone (GGA) is a drug that induces the expression of heat shock protein...

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Veröffentlicht in:	Journal of cellular biochemistry 2021-07, Vol.122 (7), p.716-730
Hauptverfasser:	Yamato, Hiroaki, Sanui, Terukazu, Yotsumoto, Karen, Nakao, Yuki, Watanabe, Yukari, Hayashi, Chikako, Aihara, Ryosuke, Iwashita, Misaki, Tanaka, Urara, Taketomi, Takaharu, Fukuda, Takao, Nishimura, Fusanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar bone Amelogenin Amphiregulin Angiogenesis Angiopoietin Bone healing Cell adhesion & migration Cytokines Drug development Endothelial cells geranylgeranylacetone GRP78 protein Heat shock proteins Hypoxia Interleukins Kinases Leukocyte migration Ligaments migration Monocyte chemoattractant protein 1 Monocytes Periodontal disease Periodontal diseases Periodontal ligament periodontal ligament cells Phosphorylation Protein kinase A Proteins Regeneration Supplements Synergistic effect Tissue engineering Tissues Ulcers Umbilical vein Wound healing
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