Oleic acid restores the rhythmicity of the disrupted circadian rhythm found in gastrointestinal explants from patients with morbid obesity
We investigated whether oleic acid (OA), one of the main components of the Mediterranean diet, participates in the regulation of the intestinal circadian rhythm in patients with morbid obesity. Stomach and jejunum explants from patients with morbid obesity were incubated with oleic acid to analyze t...
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| Veröffentlicht in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2021-06, Vol.40 (6), p.4324-4333 |
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| creator | Lago-Sampedro, Ana Ho-Plagaro, Ailec Garcia-Serrano, Sara Santiago-Fernandez, Concepción Rodríguez-Díaz, Cristina Lopez-Gómez, Carlos Martín-Reyes, Flores Ruiz-Aldea, Gonzalo Alcaín-Martínez, Guillermo Gonzalo, Montserrat Montiel-Casado, Custodia Fernández, José R. García-Fuentes, Eduardo Rodríguez-Pacheco, Francisca |
| description | We investigated whether oleic acid (OA), one of the main components of the Mediterranean diet, participates in the regulation of the intestinal circadian rhythm in patients with morbid obesity.
Stomach and jejunum explants from patients with morbid obesity were incubated with oleic acid to analyze the regulation of clock genes.
Stomach explants showed an altered circadian rhythm in CLOCK, BMAL1, REVERBα, CRY1, and CRY2, and an absence in PER1, PER2, PER3 and ghrelin (p > 0.05). OA led to the emergence of rhythmicity in PER1, PER2, PER3 and ghrelin (p 0.05). OA led to the emergence of rhythmicity in PER2, REVERBα, CRY1 and GLP1 (p 0.05). OA restored the rhythmicity of acrophase and increased the amplitude for most of the genes studied in stomach and jejunum explants. OA placed PER1, PER2, PER3, REVERBα, CRY1 and CRY2 in antiphase with regard to CLOCK and BMAL1.
There is an alteration in circadian rhythm in stomach and jejunum explants in morbid obesity. OA restored the rhythmicity of the genes related with circadian rhythm, ghrelin and GLP1, although with slight differences between tissues, which could determine a different behaviour of the explants from jejunum and stomach in obesity. |
| doi_str_mv | 10.1016/j.clnu.2021.01.015 |
| format | Article |
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Stomach and jejunum explants from patients with morbid obesity were incubated with oleic acid to analyze the regulation of clock genes.
Stomach explants showed an altered circadian rhythm in CLOCK, BMAL1, REVERBα, CRY1, and CRY2, and an absence in PER1, PER2, PER3 and ghrelin (p > 0.05). OA led to the emergence of rhythmicity in PER1, PER2, PER3 and ghrelin (p < 0.05). Jejunum explants showed an altered circadian rhythm in CLOCK, BMAL1, PER1 and PER3, and an absence in PER2, REVERBα, CRY1, CRY2 and GLP1 (p > 0.05). OA led to the emergence of rhythmicity in PER2, REVERBα, CRY1 and GLP1 (p < 0.05), but not in CRY2 (p > 0.05). OA restored the rhythmicity of acrophase and increased the amplitude for most of the genes studied in stomach and jejunum explants. OA placed PER1, PER2, PER3, REVERBα, CRY1 and CRY2 in antiphase with regard to CLOCK and BMAL1.
There is an alteration in circadian rhythm in stomach and jejunum explants in morbid obesity. OA restored the rhythmicity of the genes related with circadian rhythm, ghrelin and GLP1, although with slight differences between tissues, which could determine a different behaviour of the explants from jejunum and stomach in obesity.</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2021.01.015</identifier><identifier>PMID: 33531179</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Chronobiology ; Circadian Rhythm - drug effects ; Circadian Rhythm - genetics ; CLOCK Proteins - drug effects ; CLOCK Proteins - metabolism ; Female ; Gastrectomy - adverse effects ; Gastric Bypass - adverse effects ; Gene Expression Regulation - drug effects ; Ghrelin ; Ghrelin - genetics ; Glucagon-Like Peptide 1 - genetics ; Humans ; Jejunum ; Jejunum - metabolism ; Male ; Middle Aged ; Morbid obesity ; Obesity, Morbid - genetics ; Obesity, Morbid - surgery ; Oleic acid ; Oleic Acid - pharmacology ; Postoperative Period ; Stomach ; Stomach - metabolism</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2021-06, Vol.40 (6), p.4324-4333</ispartof><rights>2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>Copyright © 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-6651728f138ab28cd6258aeec45c68d37220fa283bdcafc066423c849a3947af3</citedby><cites>FETCH-LOGICAL-c356t-6651728f138ab28cd6258aeec45c68d37220fa283bdcafc066423c849a3947af3</cites><orcidid>0000-0002-8652-0124 ; 0000-0002-3491-2724 ; 0000-0002-3072-9981 ; 0000-0003-4439-6863</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clnu.2021.01.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33531179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lago-Sampedro, Ana</creatorcontrib><creatorcontrib>Ho-Plagaro, Ailec</creatorcontrib><creatorcontrib>Garcia-Serrano, Sara</creatorcontrib><creatorcontrib>Santiago-Fernandez, Concepción</creatorcontrib><creatorcontrib>Rodríguez-Díaz, Cristina</creatorcontrib><creatorcontrib>Lopez-Gómez, Carlos</creatorcontrib><creatorcontrib>Martín-Reyes, Flores</creatorcontrib><creatorcontrib>Ruiz-Aldea, Gonzalo</creatorcontrib><creatorcontrib>Alcaín-Martínez, Guillermo</creatorcontrib><creatorcontrib>Gonzalo, Montserrat</creatorcontrib><creatorcontrib>Montiel-Casado, Custodia</creatorcontrib><creatorcontrib>Fernández, José R.</creatorcontrib><creatorcontrib>García-Fuentes, Eduardo</creatorcontrib><creatorcontrib>Rodríguez-Pacheco, Francisca</creatorcontrib><title>Oleic acid restores the rhythmicity of the disrupted circadian rhythm found in gastrointestinal explants from patients with morbid obesity</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>We investigated whether oleic acid (OA), one of the main components of the Mediterranean diet, participates in the regulation of the intestinal circadian rhythm in patients with morbid obesity.
Stomach and jejunum explants from patients with morbid obesity were incubated with oleic acid to analyze the regulation of clock genes.
Stomach explants showed an altered circadian rhythm in CLOCK, BMAL1, REVERBα, CRY1, and CRY2, and an absence in PER1, PER2, PER3 and ghrelin (p > 0.05). OA led to the emergence of rhythmicity in PER1, PER2, PER3 and ghrelin (p < 0.05). Jejunum explants showed an altered circadian rhythm in CLOCK, BMAL1, PER1 and PER3, and an absence in PER2, REVERBα, CRY1, CRY2 and GLP1 (p > 0.05). OA led to the emergence of rhythmicity in PER2, REVERBα, CRY1 and GLP1 (p < 0.05), but not in CRY2 (p > 0.05). OA restored the rhythmicity of acrophase and increased the amplitude for most of the genes studied in stomach and jejunum explants. OA placed PER1, PER2, PER3, REVERBα, CRY1 and CRY2 in antiphase with regard to CLOCK and BMAL1.
There is an alteration in circadian rhythm in stomach and jejunum explants in morbid obesity. OA restored the rhythmicity of the genes related with circadian rhythm, ghrelin and GLP1, although with slight differences between tissues, which could determine a different behaviour of the explants from jejunum and stomach in obesity.</description><subject>Adult</subject><subject>Chronobiology</subject><subject>Circadian Rhythm - drug effects</subject><subject>Circadian Rhythm - genetics</subject><subject>CLOCK Proteins - drug effects</subject><subject>CLOCK Proteins - metabolism</subject><subject>Female</subject><subject>Gastrectomy - adverse effects</subject><subject>Gastric Bypass - adverse effects</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Ghrelin</subject><subject>Ghrelin - genetics</subject><subject>Glucagon-Like Peptide 1 - genetics</subject><subject>Humans</subject><subject>Jejunum</subject><subject>Jejunum - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morbid obesity</subject><subject>Obesity, Morbid - genetics</subject><subject>Obesity, Morbid - surgery</subject><subject>Oleic acid</subject><subject>Oleic Acid - pharmacology</subject><subject>Postoperative Period</subject><subject>Stomach</subject><subject>Stomach - metabolism</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQtRAV3Rb-AAfkI5cs_ogdr8QFVYUiVeqlPVvO2Ga9SuJgO8D-hf5qHHbhiDSa0Vhv3ozfQ-gtJVtKqPxw2MIwLVtGGN2SNcQLtKGCs4buFH-JNoRJ2ghJ20t0lfOBECJ4p16hS84Fp7TbbdDzw-ACYAPB4uRyiTXhsnc47Y9lPwYI5Yij__NkQ07LXJzFEBIYG8x0hmEfl8niMOFvJpcUw1QqV5jMgN2veTBTydinOOLZlODW7mcoezzG1Ne9sXe5rnmNLrwZsntzrtfo6fPt481dc__w5evNp_sGuJClkVLQjilPuTI9U2AlE8o4B60AqSzvGCPeMMV7C8YDkbJlHFS7M3zXdsbza_T-xDun-H2pd-oxZHBDPdPFJWvWqioZJbKrUHaCQoo5J-f1nMJo0lFTolcP9EGvHujVA03WEHXo3Zl_6Udn_438Fb0CPp4Arv7yR3BJZ6iqgLMhOSjaxvA__t_08ZuW</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Lago-Sampedro, Ana</creator><creator>Ho-Plagaro, Ailec</creator><creator>Garcia-Serrano, Sara</creator><creator>Santiago-Fernandez, Concepción</creator><creator>Rodríguez-Díaz, Cristina</creator><creator>Lopez-Gómez, Carlos</creator><creator>Martín-Reyes, Flores</creator><creator>Ruiz-Aldea, Gonzalo</creator><creator>Alcaín-Martínez, Guillermo</creator><creator>Gonzalo, Montserrat</creator><creator>Montiel-Casado, Custodia</creator><creator>Fernández, José R.</creator><creator>García-Fuentes, Eduardo</creator><creator>Rodríguez-Pacheco, Francisca</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8652-0124</orcidid><orcidid>https://orcid.org/0000-0002-3491-2724</orcidid><orcidid>https://orcid.org/0000-0002-3072-9981</orcidid><orcidid>https://orcid.org/0000-0003-4439-6863</orcidid></search><sort><creationdate>202106</creationdate><title>Oleic acid restores the rhythmicity of the disrupted circadian rhythm found in gastrointestinal explants from patients with morbid obesity</title><author>Lago-Sampedro, Ana ; Ho-Plagaro, Ailec ; Garcia-Serrano, Sara ; Santiago-Fernandez, Concepción ; Rodríguez-Díaz, Cristina ; Lopez-Gómez, Carlos ; Martín-Reyes, Flores ; Ruiz-Aldea, Gonzalo ; Alcaín-Martínez, Guillermo ; Gonzalo, Montserrat ; Montiel-Casado, Custodia ; Fernández, José R. ; García-Fuentes, Eduardo ; Rodríguez-Pacheco, Francisca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-6651728f138ab28cd6258aeec45c68d37220fa283bdcafc066423c849a3947af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Chronobiology</topic><topic>Circadian Rhythm - drug effects</topic><topic>Circadian Rhythm - genetics</topic><topic>CLOCK Proteins - drug effects</topic><topic>CLOCK Proteins - metabolism</topic><topic>Female</topic><topic>Gastrectomy - adverse effects</topic><topic>Gastric Bypass - adverse effects</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Ghrelin</topic><topic>Ghrelin - genetics</topic><topic>Glucagon-Like Peptide 1 - genetics</topic><topic>Humans</topic><topic>Jejunum</topic><topic>Jejunum - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morbid obesity</topic><topic>Obesity, Morbid - genetics</topic><topic>Obesity, Morbid - surgery</topic><topic>Oleic acid</topic><topic>Oleic Acid - pharmacology</topic><topic>Postoperative Period</topic><topic>Stomach</topic><topic>Stomach - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lago-Sampedro, Ana</creatorcontrib><creatorcontrib>Ho-Plagaro, Ailec</creatorcontrib><creatorcontrib>Garcia-Serrano, Sara</creatorcontrib><creatorcontrib>Santiago-Fernandez, Concepción</creatorcontrib><creatorcontrib>Rodríguez-Díaz, Cristina</creatorcontrib><creatorcontrib>Lopez-Gómez, Carlos</creatorcontrib><creatorcontrib>Martín-Reyes, Flores</creatorcontrib><creatorcontrib>Ruiz-Aldea, Gonzalo</creatorcontrib><creatorcontrib>Alcaín-Martínez, Guillermo</creatorcontrib><creatorcontrib>Gonzalo, Montserrat</creatorcontrib><creatorcontrib>Montiel-Casado, Custodia</creatorcontrib><creatorcontrib>Fernández, José R.</creatorcontrib><creatorcontrib>García-Fuentes, Eduardo</creatorcontrib><creatorcontrib>Rodríguez-Pacheco, Francisca</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lago-Sampedro, Ana</au><au>Ho-Plagaro, Ailec</au><au>Garcia-Serrano, Sara</au><au>Santiago-Fernandez, Concepción</au><au>Rodríguez-Díaz, Cristina</au><au>Lopez-Gómez, Carlos</au><au>Martín-Reyes, Flores</au><au>Ruiz-Aldea, Gonzalo</au><au>Alcaín-Martínez, Guillermo</au><au>Gonzalo, Montserrat</au><au>Montiel-Casado, Custodia</au><au>Fernández, José R.</au><au>García-Fuentes, Eduardo</au><au>Rodríguez-Pacheco, Francisca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oleic acid restores the rhythmicity of the disrupted circadian rhythm found in gastrointestinal explants from patients with morbid obesity</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2021-06</date><risdate>2021</risdate><volume>40</volume><issue>6</issue><spage>4324</spage><epage>4333</epage><pages>4324-4333</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><abstract>We investigated whether oleic acid (OA), one of the main components of the Mediterranean diet, participates in the regulation of the intestinal circadian rhythm in patients with morbid obesity.
Stomach and jejunum explants from patients with morbid obesity were incubated with oleic acid to analyze the regulation of clock genes.
Stomach explants showed an altered circadian rhythm in CLOCK, BMAL1, REVERBα, CRY1, and CRY2, and an absence in PER1, PER2, PER3 and ghrelin (p > 0.05). OA led to the emergence of rhythmicity in PER1, PER2, PER3 and ghrelin (p < 0.05). Jejunum explants showed an altered circadian rhythm in CLOCK, BMAL1, PER1 and PER3, and an absence in PER2, REVERBα, CRY1, CRY2 and GLP1 (p > 0.05). OA led to the emergence of rhythmicity in PER2, REVERBα, CRY1 and GLP1 (p < 0.05), but not in CRY2 (p > 0.05). OA restored the rhythmicity of acrophase and increased the amplitude for most of the genes studied in stomach and jejunum explants. OA placed PER1, PER2, PER3, REVERBα, CRY1 and CRY2 in antiphase with regard to CLOCK and BMAL1.
There is an alteration in circadian rhythm in stomach and jejunum explants in morbid obesity. OA restored the rhythmicity of the genes related with circadian rhythm, ghrelin and GLP1, although with slight differences between tissues, which could determine a different behaviour of the explants from jejunum and stomach in obesity.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33531179</pmid><doi>10.1016/j.clnu.2021.01.015</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8652-0124</orcidid><orcidid>https://orcid.org/0000-0002-3491-2724</orcidid><orcidid>https://orcid.org/0000-0002-3072-9981</orcidid><orcidid>https://orcid.org/0000-0003-4439-6863</orcidid></addata></record> |
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| ispartof | Clinical nutrition (Edinburgh, Scotland), 2021-06, Vol.40 (6), p.4324-4333 |
| issn | 0261-5614 1532-1983 |
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| subjects | Adult Chronobiology Circadian Rhythm - drug effects Circadian Rhythm - genetics CLOCK Proteins - drug effects CLOCK Proteins - metabolism Female Gastrectomy - adverse effects Gastric Bypass - adverse effects Gene Expression Regulation - drug effects Ghrelin Ghrelin - genetics Glucagon-Like Peptide 1 - genetics Humans Jejunum Jejunum - metabolism Male Middle Aged Morbid obesity Obesity, Morbid - genetics Obesity, Morbid - surgery Oleic acid Oleic Acid - pharmacology Postoperative Period Stomach Stomach - metabolism |
| title | Oleic acid restores the rhythmicity of the disrupted circadian rhythm found in gastrointestinal explants from patients with morbid obesity |
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