The Association Between Antidepressant Effect of SSRIs and Astrocytes: Conceptual Overview and Meta‐analysis of the Literature

Major depressive disorders (MDD) a worldwide psychiatric disease, is yet to be adequately controlled by therapies; while the mechanisms of action of antidepressants are yet to be fully characterised. In the last two decades, an increasing number of studies have demonstrated the role of astrocytes in...

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Veröffentlicht in:	Neurochemical research 2021-10, Vol.46 (10), p.2731-2745
Hauptverfasser:	Chen, Beina, Zhang, Manman, Ji, Ming, Gong, Wenliang, Chen, Binjie, Zorec, Robert, Stenovec, Matjaž, Verkhratsky, Alexei, Li, Baoman
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal behavior Animals Antidepressants Antidepressive Agents - therapeutic use Astrocytes Astrocytes - drug effects Astrocytes - metabolism Behavior, Animal - drug effects Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cell Count Central nervous system Depressive Disorder, Major - drug therapy Depressive Disorder, Major - metabolism Fluoxetine Gene expression Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - metabolism Humans Mental depression Mental disorders Meta-analysis Mice Neurochemistry Neurology Neurosciences Original Paper Pathophysiology Rats Receptors, Serotonin, 5-HT2 - metabolism Reviews Selective Serotonin Reuptake Inhibitors - therapeutic use Serotonin Serotonin S2 receptors Serotonin uptake inhibitors Signal transduction
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