A Novel Mitochondrial Complex of Aldosterone Synthase, Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes Aldosterone in the Rat Heart

Aldosterone, which regulates renal salt retention, is synthesized in adrenocortical mitochondria in response to angiotensin II. Excess aldosterone causes myocardial injury and heart failure, but potential intracardiac aldosterone synthesis has been controversial. We hypothesized that the stressed he...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2021-04, Vol.377 (1), p.108-120
Hauptverfasser:	Bose, Himangshu S., Whittal, Randy M., Marshall, Brendan, Rajapaksha, Maheshinie, Wang, Ning Ping, Bose, Madhuchanda, Perry, Elizabeth W., Zhao, Zhi-Qing, Miller, Walter L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone - biosynthesis Animals Cell Line Corticosterone - metabolism Cytochrome P-450 CYP11B2 - metabolism Male Mitochondria, Heart - metabolism Mitochondrial Membrane Transport Proteins - metabolism Myocardium - metabolism Phosphoproteins - metabolism Rats Rats, Sprague-Dawley
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!