Gain of HIF1 Activity and Loss of miRNA let-7d Promote Breast Cancer Metastasis to the Brain via the PDGF/PDGFR Axis

Early detection and adjuvant therapies have significantly improved survival of patients with breast cancer over the past three decades. In contrast, management of metastatic disease remains unresolved. Brain metastasis is a late complication frequently observed among patients with metastatic breast...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2021-02, Vol.81 (3), p.594-605
Hauptverfasser:	Wyss, Christof B, Duffey, Nathalie, Peyvandi, Sanam, Barras, David, Martinez Usatorre, Amaïa, Coquoz, Oriana, Romero, Pedro, Delorenzi, Mauro, Lorusso, Girieca, Rüegg, Curzio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Breast Neoplasms - genetics Cell Line, Tumor Humans Hypoxia-Inducible Factor 1 Mice MicroRNAs - genetics Platelet-Derived Growth Factor - genetics
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