The role of exosomal microRNAs in central nervous system diseases
MicroRNAs (miRNA), endogenous non-coding RNAs approximately 22 nucleotides long, regulate gene expression by mediating translational inhibition or mRNA degradation. Exosomes are a tool for intercellular transmission of information in which miRNA exchange plays an important role. Under pathophysiolog...
Gespeichert in:
| Veröffentlicht in: | Molecular and cellular biochemistry 2021-05, Vol.476 (5), p.2111-2124 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2124 |
|---|---|
| container_issue | 5 |
| container_start_page | 2111 |
| container_title | Molecular and cellular biochemistry |
| container_volume | 476 |
| creator | Yu, Yifei Hou, Kun Ji, Tong Wang, Xishu Liu, Yining Zheng, Yangyang Xu, Jinying Hou, Yi Chi, Guangfan |
| description | MicroRNAs (miRNA), endogenous non-coding RNAs approximately 22 nucleotides long, regulate gene expression by mediating translational inhibition or mRNA degradation. Exosomes are a tool for intercellular transmission of information in which miRNA exchange plays an important role. Under pathophysiological conditions in the central nervous system (CNS), cellular transmission of exosomal miRNAs can regulate signaling pathways. Exosomal miRNAs are involved in the occurrence and development of diverse CNS diseases, such as traumatic brain injury, spinal cord injury, stroke, neurodegenerative diseases, epilepsy, and glioma. The use of exosomes as transport vehicles for certain miRNAs provides a novel therapeutic strategy for CNS diseases. Furthermore, the exosomes in body fluids change with the occurrence of diseases, indicating that subtle changes in physiological and pathological processes in vivo could be recognized by analyzing exosomes. Exosomal analysis is expected to act as a novel tool for diagnosis and prediction of neurological diseases. In this review, we present the current understanding of the implications of miRNAs in CNS diseases and summarize the role and mechanism of action of exosomal miRNA in nervous system disease models. |
| doi_str_mv | 10.1007/s11010-021-04053-0 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2485518946</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A659190578</galeid><sourcerecordid>A659190578</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-5daefb1cb3e30a6f998395007723e15790caafde92c8c1571006fec34f8cab5b3</originalsourceid><addsrcrecordid>eNp9kU1P3DAQhq2KCpaPP8ChisSFS-g4jpP4uELlQ0JFQnC2HGdMg5KYenZR998zywIVVYV8sGw_7_ideYU4lHAiAervJCVIyKGQOZSgVQ5fxEzqWuWlkWZLzEAB5I2s6x2xS_QATIOU22JHKV00NVQzMb_9hVmKA2YxZPgnUhzdkI29T_Hm55yyfso8TovElxOmp7ikjFa0wDHrekJHSPvia3AD4cHrvifuzn7cnl7kV9fnl6fzq9yXZbHIdecwtNK3ChW4KhjTKKO5jbpQyKYNeOdCh6bwjeczW60CelWGxrtWt2pPHG_qPqb4e4m0sGNPHofBTci2bFE2WsvGlBWjR_-gD3GZJnZnCy11WZuKf3-n7t2Atp9C5Db9uqidV5onCLpeUyf_oXh1yFOKE4ae7z8Iio2AR0iUMNjH1I8urawEu87NbnKznJt9yc0Ci769Ol62I3bvkregGFAbgPhpusf0t6VPyj4DYs2gFw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2515479698</pqid></control><display><type>article</type><title>The role of exosomal microRNAs in central nervous system diseases</title><source>SpringerLink Journals - AutoHoldings</source><creator>Yu, Yifei ; Hou, Kun ; Ji, Tong ; Wang, Xishu ; Liu, Yining ; Zheng, Yangyang ; Xu, Jinying ; Hou, Yi ; Chi, Guangfan</creator><creatorcontrib>Yu, Yifei ; Hou, Kun ; Ji, Tong ; Wang, Xishu ; Liu, Yining ; Zheng, Yangyang ; Xu, Jinying ; Hou, Yi ; Chi, Guangfan</creatorcontrib><description>MicroRNAs (miRNA), endogenous non-coding RNAs approximately 22 nucleotides long, regulate gene expression by mediating translational inhibition or mRNA degradation. Exosomes are a tool for intercellular transmission of information in which miRNA exchange plays an important role. Under pathophysiological conditions in the central nervous system (CNS), cellular transmission of exosomal miRNAs can regulate signaling pathways. Exosomal miRNAs are involved in the occurrence and development of diverse CNS diseases, such as traumatic brain injury, spinal cord injury, stroke, neurodegenerative diseases, epilepsy, and glioma. The use of exosomes as transport vehicles for certain miRNAs provides a novel therapeutic strategy for CNS diseases. Furthermore, the exosomes in body fluids change with the occurrence of diseases, indicating that subtle changes in physiological and pathological processes in vivo could be recognized by analyzing exosomes. Exosomal analysis is expected to act as a novel tool for diagnosis and prediction of neurological diseases. In this review, we present the current understanding of the implications of miRNAs in CNS diseases and summarize the role and mechanism of action of exosomal miRNA in nervous system disease models.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-021-04053-0</identifier><identifier>PMID: 33528706</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analysis ; Biochemistry ; Biomedical and Life Sciences ; Body fluids ; Brain ; Brain tumors ; Cardiology ; Central nervous system ; Central nervous system diseases ; Computational fluid dynamics ; Development and progression ; Epilepsy ; Exosomes ; Gene expression ; Glioma ; Head injuries ; Information management ; Injuries ; Life Sciences ; Medical Biochemistry ; MicroRNA ; MicroRNAs ; miRNA ; Nervous system ; Neurodegenerative diseases ; Neurological diseases ; Non-coding RNA ; Nucleotides ; Oncology ; Physiological aspects ; Ribonucleic acid ; RNA ; Spinal cord injuries ; Transport vehicles ; Traumatic brain injury</subject><ispartof>Molecular and cellular biochemistry, 2021-05, Vol.476 (5), p.2111-2124</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-5daefb1cb3e30a6f998395007723e15790caafde92c8c1571006fec34f8cab5b3</citedby><cites>FETCH-LOGICAL-c442t-5daefb1cb3e30a6f998395007723e15790caafde92c8c1571006fec34f8cab5b3</cites><orcidid>0000-0001-7096-9106</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11010-021-04053-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11010-021-04053-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33528706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Yifei</creatorcontrib><creatorcontrib>Hou, Kun</creatorcontrib><creatorcontrib>Ji, Tong</creatorcontrib><creatorcontrib>Wang, Xishu</creatorcontrib><creatorcontrib>Liu, Yining</creatorcontrib><creatorcontrib>Zheng, Yangyang</creatorcontrib><creatorcontrib>Xu, Jinying</creatorcontrib><creatorcontrib>Hou, Yi</creatorcontrib><creatorcontrib>Chi, Guangfan</creatorcontrib><title>The role of exosomal microRNAs in central nervous system diseases</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description>MicroRNAs (miRNA), endogenous non-coding RNAs approximately 22 nucleotides long, regulate gene expression by mediating translational inhibition or mRNA degradation. Exosomes are a tool for intercellular transmission of information in which miRNA exchange plays an important role. Under pathophysiological conditions in the central nervous system (CNS), cellular transmission of exosomal miRNAs can regulate signaling pathways. Exosomal miRNAs are involved in the occurrence and development of diverse CNS diseases, such as traumatic brain injury, spinal cord injury, stroke, neurodegenerative diseases, epilepsy, and glioma. The use of exosomes as transport vehicles for certain miRNAs provides a novel therapeutic strategy for CNS diseases. Furthermore, the exosomes in body fluids change with the occurrence of diseases, indicating that subtle changes in physiological and pathological processes in vivo could be recognized by analyzing exosomes. Exosomal analysis is expected to act as a novel tool for diagnosis and prediction of neurological diseases. In this review, we present the current understanding of the implications of miRNAs in CNS diseases and summarize the role and mechanism of action of exosomal miRNA in nervous system disease models.</description><subject>Analysis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Body fluids</subject><subject>Brain</subject><subject>Brain tumors</subject><subject>Cardiology</subject><subject>Central nervous system</subject><subject>Central nervous system diseases</subject><subject>Computational fluid dynamics</subject><subject>Development and progression</subject><subject>Epilepsy</subject><subject>Exosomes</subject><subject>Gene expression</subject><subject>Glioma</subject><subject>Head injuries</subject><subject>Information management</subject><subject>Injuries</subject><subject>Life Sciences</subject><subject>Medical Biochemistry</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Nervous system</subject><subject>Neurodegenerative diseases</subject><subject>Neurological diseases</subject><subject>Non-coding RNA</subject><subject>Nucleotides</subject><subject>Oncology</subject><subject>Physiological aspects</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Spinal cord injuries</subject><subject>Transport vehicles</subject><subject>Traumatic brain injury</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1P3DAQhq2KCpaPP8ChisSFS-g4jpP4uELlQ0JFQnC2HGdMg5KYenZR998zywIVVYV8sGw_7_ideYU4lHAiAervJCVIyKGQOZSgVQ5fxEzqWuWlkWZLzEAB5I2s6x2xS_QATIOU22JHKV00NVQzMb_9hVmKA2YxZPgnUhzdkI29T_Hm55yyfso8TovElxOmp7ikjFa0wDHrekJHSPvia3AD4cHrvifuzn7cnl7kV9fnl6fzq9yXZbHIdecwtNK3ChW4KhjTKKO5jbpQyKYNeOdCh6bwjeczW60CelWGxrtWt2pPHG_qPqb4e4m0sGNPHofBTci2bFE2WsvGlBWjR_-gD3GZJnZnCy11WZuKf3-n7t2Atp9C5Db9uqidV5onCLpeUyf_oXh1yFOKE4ae7z8Iio2AR0iUMNjH1I8urawEu87NbnKznJt9yc0Ci769Ol62I3bvkregGFAbgPhpusf0t6VPyj4DYs2gFw</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Yu, Yifei</creator><creator>Hou, Kun</creator><creator>Ji, Tong</creator><creator>Wang, Xishu</creator><creator>Liu, Yining</creator><creator>Zheng, Yangyang</creator><creator>Xu, Jinying</creator><creator>Hou, Yi</creator><creator>Chi, Guangfan</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7096-9106</orcidid></search><sort><creationdate>20210501</creationdate><title>The role of exosomal microRNAs in central nervous system diseases</title><author>Yu, Yifei ; Hou, Kun ; Ji, Tong ; Wang, Xishu ; Liu, Yining ; Zheng, Yangyang ; Xu, Jinying ; Hou, Yi ; Chi, Guangfan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-5daefb1cb3e30a6f998395007723e15790caafde92c8c1571006fec34f8cab5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Body fluids</topic><topic>Brain</topic><topic>Brain tumors</topic><topic>Cardiology</topic><topic>Central nervous system</topic><topic>Central nervous system diseases</topic><topic>Computational fluid dynamics</topic><topic>Development and progression</topic><topic>Epilepsy</topic><topic>Exosomes</topic><topic>Gene expression</topic><topic>Glioma</topic><topic>Head injuries</topic><topic>Information management</topic><topic>Injuries</topic><topic>Life Sciences</topic><topic>Medical Biochemistry</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>miRNA</topic><topic>Nervous system</topic><topic>Neurodegenerative diseases</topic><topic>Neurological diseases</topic><topic>Non-coding RNA</topic><topic>Nucleotides</topic><topic>Oncology</topic><topic>Physiological aspects</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Spinal cord injuries</topic><topic>Transport vehicles</topic><topic>Traumatic brain injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Yifei</creatorcontrib><creatorcontrib>Hou, Kun</creatorcontrib><creatorcontrib>Ji, Tong</creatorcontrib><creatorcontrib>Wang, Xishu</creatorcontrib><creatorcontrib>Liu, Yining</creatorcontrib><creatorcontrib>Zheng, Yangyang</creatorcontrib><creatorcontrib>Xu, Jinying</creatorcontrib><creatorcontrib>Hou, Yi</creatorcontrib><creatorcontrib>Chi, Guangfan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Yifei</au><au>Hou, Kun</au><au>Ji, Tong</au><au>Wang, Xishu</au><au>Liu, Yining</au><au>Zheng, Yangyang</au><au>Xu, Jinying</au><au>Hou, Yi</au><au>Chi, Guangfan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of exosomal microRNAs in central nervous system diseases</atitle><jtitle>Molecular and cellular biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><addtitle>Mol Cell Biochem</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>476</volume><issue>5</issue><spage>2111</spage><epage>2124</epage><pages>2111-2124</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>MicroRNAs (miRNA), endogenous non-coding RNAs approximately 22 nucleotides long, regulate gene expression by mediating translational inhibition or mRNA degradation. Exosomes are a tool for intercellular transmission of information in which miRNA exchange plays an important role. Under pathophysiological conditions in the central nervous system (CNS), cellular transmission of exosomal miRNAs can regulate signaling pathways. Exosomal miRNAs are involved in the occurrence and development of diverse CNS diseases, such as traumatic brain injury, spinal cord injury, stroke, neurodegenerative diseases, epilepsy, and glioma. The use of exosomes as transport vehicles for certain miRNAs provides a novel therapeutic strategy for CNS diseases. Furthermore, the exosomes in body fluids change with the occurrence of diseases, indicating that subtle changes in physiological and pathological processes in vivo could be recognized by analyzing exosomes. Exosomal analysis is expected to act as a novel tool for diagnosis and prediction of neurological diseases. In this review, we present the current understanding of the implications of miRNAs in CNS diseases and summarize the role and mechanism of action of exosomal miRNA in nervous system disease models.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33528706</pmid><doi>10.1007/s11010-021-04053-0</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-7096-9106</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8177 |
| ispartof | Molecular and cellular biochemistry, 2021-05, Vol.476 (5), p.2111-2124 |
| issn | 0300-8177 1573-4919 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2485518946 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Analysis Biochemistry Biomedical and Life Sciences Body fluids Brain Brain tumors Cardiology Central nervous system Central nervous system diseases Computational fluid dynamics Development and progression Epilepsy Exosomes Gene expression Glioma Head injuries Information management Injuries Life Sciences Medical Biochemistry MicroRNA MicroRNAs miRNA Nervous system Neurodegenerative diseases Neurological diseases Non-coding RNA Nucleotides Oncology Physiological aspects Ribonucleic acid RNA Spinal cord injuries Transport vehicles Traumatic brain injury |
| title | The role of exosomal microRNAs in central nervous system diseases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T07%3A44%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20exosomal%20microRNAs%20in%20central%20nervous%20system%20diseases&rft.jtitle=Molecular%20and%20cellular%20biochemistry&rft.au=Yu,%20Yifei&rft.date=2021-05-01&rft.volume=476&rft.issue=5&rft.spage=2111&rft.epage=2124&rft.pages=2111-2124&rft.issn=0300-8177&rft.eissn=1573-4919&rft_id=info:doi/10.1007/s11010-021-04053-0&rft_dat=%3Cgale_proqu%3EA659190578%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2515479698&rft_id=info:pmid/33528706&rft_galeid=A659190578&rfr_iscdi=true |