The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells
Anthocyanins have been reported to have effective chemopreventive activity. Lycium ruthenicum Murray is rich in anthocyanins and exhibits many biological activities. The purpose of this study was to investigate the effects and possible biological mechanism of the main anthocyanin monomer (Pt3G) of L...
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| Veröffentlicht in: | Food & function 2021-02, Vol.12 (4), p.1818-1828 |
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| creator | Li, Zhan-Long Mi, Jia Lu, Lu Luo, Qing Liu, Xi Yan, Ya-Mei Jin, Bo Cao, You-Long Zeng, Xiao-Xiong Ran, Lin-Wu |
| description | Anthocyanins have been reported to have effective chemopreventive activity. Lycium ruthenicum Murray is rich in anthocyanins and exhibits many biological activities. The purpose of this study was to investigate the effects and possible biological mechanism of the main anthocyanin monomer (Pt3G) of Lycium ruthenicum Murray on prostate cancer DU-145 cells. The cell proliferation was detected by methyl thiazolyl tetrazolium assay. The cell apoptosis rates were assessed by flow cytometric analysis and TUNEL assay. The expressions of apoptosis related proteins were evaluated by western blotting. Our data demonstrated that Pt3G inhibited cell proliferation, induced apoptosis and promoted cell cycle arrest at the S phase in a concentration-dependent manner (0, 100, 200 and 400 μg mL
). Furthermore, it was shown that Pt3G decreased the mitochondrial membrane permeability through regulating the expressions of Bax and Bcl-2. Western blot analysis indicated that Pt3G significantly increased the expression of PTEN and then activated the PI3K/Akt-mediated caspase 3 pathway. In addition, our results also suggested that Pt3G activated the PTEN gene to induce the apoptosis of DU-145 cells by stimulating the overproduction of ROS. To sum up, these results indicate that Pt3G inhibits cell proliferation and induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells. Therefore, Pt3G of Lycium ruthenicum Murray may be a potential anti-proliferative agent for the prevention or treatment of prostate cancer. |
| doi_str_mv | 10.1039/d0fo02382e |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2485516541</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2485516541</sourcerecordid><originalsourceid>FETCH-LOGICAL-c315t-a1b1d03799027c18ae7cb65aafb119d808526d624270ce8a981f60372c5910223</originalsourceid><addsrcrecordid>eNpdkUtv1DAUhS0EolXphh-ALLFBSCF-xIm9rNoprRiYCqYSu-iO40xSJnbwQ2j-T38onj5YcDf3LD6de48OQm8p-UQJV2VHekcYl8y8QMeMVKyoBfn58llXqj5CpyHckTxcKanka3TEuWCNEuIY3a8HgycYLQYbB6f3YLOenHWT8dj1eLnXY5qwT3EwdtRZfk3ewx6PtkvaBAyzm6MLY8Bx8C5th7wN_r76Ud6sF9_Km2v-pTz7FUsNYYZgMMdh3FrYjXaLZ4jDnwcvPHsXIkSDNVidT1_cFrQSWJvdLrxBr3rYBXP6tE_Q7eVifX5VLFefr8_PloXmVMQC6IZ2hDdKEdZoKsE0elMLgH5DqeokkYLVXc0q1hBtJChJ-zrzTAtFCWP8BH149M3P_E4mxHYaw-EDsMal0LJKCkFrUdGMvv8PvXPJ51gHSlW8ETVTmfr4SOmcLnjTt7MfJ_D7lpL2UF97QS5XD_UtMvzuyTJtJtP9Q5_L4n8BPeiUeg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2494375629</pqid></control><display><type>article</type><title>The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><creator>Li, Zhan-Long ; Mi, Jia ; Lu, Lu ; Luo, Qing ; Liu, Xi ; Yan, Ya-Mei ; Jin, Bo ; Cao, You-Long ; Zeng, Xiao-Xiong ; Ran, Lin-Wu</creator><creatorcontrib>Li, Zhan-Long ; Mi, Jia ; Lu, Lu ; Luo, Qing ; Liu, Xi ; Yan, Ya-Mei ; Jin, Bo ; Cao, You-Long ; Zeng, Xiao-Xiong ; Ran, Lin-Wu</creatorcontrib><description>Anthocyanins have been reported to have effective chemopreventive activity. Lycium ruthenicum Murray is rich in anthocyanins and exhibits many biological activities. The purpose of this study was to investigate the effects and possible biological mechanism of the main anthocyanin monomer (Pt3G) of Lycium ruthenicum Murray on prostate cancer DU-145 cells. The cell proliferation was detected by methyl thiazolyl tetrazolium assay. The cell apoptosis rates were assessed by flow cytometric analysis and TUNEL assay. The expressions of apoptosis related proteins were evaluated by western blotting. Our data demonstrated that Pt3G inhibited cell proliferation, induced apoptosis and promoted cell cycle arrest at the S phase in a concentration-dependent manner (0, 100, 200 and 400 μg mL
). Furthermore, it was shown that Pt3G decreased the mitochondrial membrane permeability through regulating the expressions of Bax and Bcl-2. Western blot analysis indicated that Pt3G significantly increased the expression of PTEN and then activated the PI3K/Akt-mediated caspase 3 pathway. In addition, our results also suggested that Pt3G activated the PTEN gene to induce the apoptosis of DU-145 cells by stimulating the overproduction of ROS. To sum up, these results indicate that Pt3G inhibits cell proliferation and induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells. Therefore, Pt3G of Lycium ruthenicum Murray may be a potential anti-proliferative agent for the prevention or treatment of prostate cancer.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d0fo02382e</identifier><identifier>PMID: 33527955</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>1-Phosphatidylinositol 3-kinase ; AKT protein ; Anthocyanins ; Anthocyanins - isolation & purification ; Anthocyanins - pharmacology ; Antineoplastic Agents, Phytogenic - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Bax protein ; Bcl-2 protein ; Biological effects ; Caspase 3 - metabolism ; Caspase-3 ; Cell cycle ; Cell growth ; Cell Line, Tumor ; Cell proliferation ; Cell Proliferation - drug effects ; Flow cytometry ; Fruit - chemistry ; Glucosides - isolation & purification ; Glucosides - pharmacology ; Humans ; Lycium - chemistry ; Lycium ruthenicum ; Male ; Membrane permeability ; Membrane Potential, Mitochondrial - drug effects ; Mitochondria ; Monomers ; Phosphatidylinositol 3-Kinases - metabolism ; Prostate cancer ; Prostatic Neoplasms - drug therapy ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - prevention & control ; Proto-Oncogene Proteins c-akt - metabolism ; PTEN Phosphohydrolase - metabolism ; PTEN protein ; Reactive Oxygen Species - metabolism ; S phase ; Signal transduction ; Signal Transduction - drug effects ; Signaling ; Western blotting</subject><ispartof>Food & function, 2021-02, Vol.12 (4), p.1818-1828</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-a1b1d03799027c18ae7cb65aafb119d808526d624270ce8a981f60372c5910223</citedby><cites>FETCH-LOGICAL-c315t-a1b1d03799027c18ae7cb65aafb119d808526d624270ce8a981f60372c5910223</cites><orcidid>0000-0003-1353-1217 ; 0000-0003-2954-3896</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33527955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Zhan-Long</creatorcontrib><creatorcontrib>Mi, Jia</creatorcontrib><creatorcontrib>Lu, Lu</creatorcontrib><creatorcontrib>Luo, Qing</creatorcontrib><creatorcontrib>Liu, Xi</creatorcontrib><creatorcontrib>Yan, Ya-Mei</creatorcontrib><creatorcontrib>Jin, Bo</creatorcontrib><creatorcontrib>Cao, You-Long</creatorcontrib><creatorcontrib>Zeng, Xiao-Xiong</creatorcontrib><creatorcontrib>Ran, Lin-Wu</creatorcontrib><title>The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Anthocyanins have been reported to have effective chemopreventive activity. Lycium ruthenicum Murray is rich in anthocyanins and exhibits many biological activities. The purpose of this study was to investigate the effects and possible biological mechanism of the main anthocyanin monomer (Pt3G) of Lycium ruthenicum Murray on prostate cancer DU-145 cells. The cell proliferation was detected by methyl thiazolyl tetrazolium assay. The cell apoptosis rates were assessed by flow cytometric analysis and TUNEL assay. The expressions of apoptosis related proteins were evaluated by western blotting. Our data demonstrated that Pt3G inhibited cell proliferation, induced apoptosis and promoted cell cycle arrest at the S phase in a concentration-dependent manner (0, 100, 200 and 400 μg mL
). Furthermore, it was shown that Pt3G decreased the mitochondrial membrane permeability through regulating the expressions of Bax and Bcl-2. Western blot analysis indicated that Pt3G significantly increased the expression of PTEN and then activated the PI3K/Akt-mediated caspase 3 pathway. In addition, our results also suggested that Pt3G activated the PTEN gene to induce the apoptosis of DU-145 cells by stimulating the overproduction of ROS. To sum up, these results indicate that Pt3G inhibits cell proliferation and induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells. Therefore, Pt3G of Lycium ruthenicum Murray may be a potential anti-proliferative agent for the prevention or treatment of prostate cancer.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>AKT protein</subject><subject>Anthocyanins</subject><subject>Anthocyanins - isolation & purification</subject><subject>Anthocyanins - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Bax protein</subject><subject>Bcl-2 protein</subject><subject>Biological effects</subject><subject>Caspase 3 - metabolism</subject><subject>Caspase-3</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Flow cytometry</subject><subject>Fruit - chemistry</subject><subject>Glucosides - isolation & purification</subject><subject>Glucosides - pharmacology</subject><subject>Humans</subject><subject>Lycium - chemistry</subject><subject>Lycium ruthenicum</subject><subject>Male</subject><subject>Membrane permeability</subject><subject>Membrane Potential, Mitochondrial - drug effects</subject><subject>Mitochondria</subject><subject>Monomers</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - prevention & control</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>PTEN Phosphohydrolase - metabolism</subject><subject>PTEN protein</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>S phase</subject><subject>Signal transduction</subject><subject>Signal Transduction - drug effects</subject><subject>Signaling</subject><subject>Western blotting</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtv1DAUhS0EolXphh-ALLFBSCF-xIm9rNoprRiYCqYSu-iO40xSJnbwQ2j-T38onj5YcDf3LD6de48OQm8p-UQJV2VHekcYl8y8QMeMVKyoBfn58llXqj5CpyHckTxcKanka3TEuWCNEuIY3a8HgycYLQYbB6f3YLOenHWT8dj1eLnXY5qwT3EwdtRZfk3ewx6PtkvaBAyzm6MLY8Bx8C5th7wN_r76Ud6sF9_Km2v-pTz7FUsNYYZgMMdh3FrYjXaLZ4jDnwcvPHsXIkSDNVidT1_cFrQSWJvdLrxBr3rYBXP6tE_Q7eVifX5VLFefr8_PloXmVMQC6IZ2hDdKEdZoKsE0elMLgH5DqeokkYLVXc0q1hBtJChJ-zrzTAtFCWP8BH149M3P_E4mxHYaw-EDsMal0LJKCkFrUdGMvv8PvXPJ51gHSlW8ETVTmfr4SOmcLnjTt7MfJ_D7lpL2UF97QS5XD_UtMvzuyTJtJtP9Q5_L4n8BPeiUeg</recordid><startdate>20210221</startdate><enddate>20210221</enddate><creator>Li, Zhan-Long</creator><creator>Mi, Jia</creator><creator>Lu, Lu</creator><creator>Luo, Qing</creator><creator>Liu, Xi</creator><creator>Yan, Ya-Mei</creator><creator>Jin, Bo</creator><creator>Cao, You-Long</creator><creator>Zeng, Xiao-Xiong</creator><creator>Ran, Lin-Wu</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1353-1217</orcidid><orcidid>https://orcid.org/0000-0003-2954-3896</orcidid></search><sort><creationdate>20210221</creationdate><title>The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells</title><author>Li, Zhan-Long ; Mi, Jia ; Lu, Lu ; Luo, Qing ; Liu, Xi ; Yan, Ya-Mei ; Jin, Bo ; Cao, You-Long ; Zeng, Xiao-Xiong ; Ran, Lin-Wu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-a1b1d03799027c18ae7cb65aafb119d808526d624270ce8a981f60372c5910223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>AKT protein</topic><topic>Anthocyanins</topic><topic>Anthocyanins - isolation & purification</topic><topic>Anthocyanins - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Bax protein</topic><topic>Bcl-2 protein</topic><topic>Biological effects</topic><topic>Caspase 3 - metabolism</topic><topic>Caspase-3</topic><topic>Cell cycle</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Flow cytometry</topic><topic>Fruit - chemistry</topic><topic>Glucosides - isolation & purification</topic><topic>Glucosides - pharmacology</topic><topic>Humans</topic><topic>Lycium - chemistry</topic><topic>Lycium ruthenicum</topic><topic>Male</topic><topic>Membrane permeability</topic><topic>Membrane Potential, Mitochondrial - drug effects</topic><topic>Mitochondria</topic><topic>Monomers</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - prevention & control</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>PTEN Phosphohydrolase - metabolism</topic><topic>PTEN protein</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>S phase</topic><topic>Signal transduction</topic><topic>Signal Transduction - drug effects</topic><topic>Signaling</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Zhan-Long</creatorcontrib><creatorcontrib>Mi, Jia</creatorcontrib><creatorcontrib>Lu, Lu</creatorcontrib><creatorcontrib>Luo, Qing</creatorcontrib><creatorcontrib>Liu, Xi</creatorcontrib><creatorcontrib>Yan, Ya-Mei</creatorcontrib><creatorcontrib>Jin, Bo</creatorcontrib><creatorcontrib>Cao, You-Long</creatorcontrib><creatorcontrib>Zeng, Xiao-Xiong</creatorcontrib><creatorcontrib>Ran, Lin-Wu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Zhan-Long</au><au>Mi, Jia</au><au>Lu, Lu</au><au>Luo, Qing</au><au>Liu, Xi</au><au>Yan, Ya-Mei</au><au>Jin, Bo</au><au>Cao, You-Long</au><au>Zeng, Xiao-Xiong</au><au>Ran, Lin-Wu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2021-02-21</date><risdate>2021</risdate><volume>12</volume><issue>4</issue><spage>1818</spage><epage>1828</epage><pages>1818-1828</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Anthocyanins have been reported to have effective chemopreventive activity. Lycium ruthenicum Murray is rich in anthocyanins and exhibits many biological activities. The purpose of this study was to investigate the effects and possible biological mechanism of the main anthocyanin monomer (Pt3G) of Lycium ruthenicum Murray on prostate cancer DU-145 cells. The cell proliferation was detected by methyl thiazolyl tetrazolium assay. The cell apoptosis rates were assessed by flow cytometric analysis and TUNEL assay. The expressions of apoptosis related proteins were evaluated by western blotting. Our data demonstrated that Pt3G inhibited cell proliferation, induced apoptosis and promoted cell cycle arrest at the S phase in a concentration-dependent manner (0, 100, 200 and 400 μg mL
). Furthermore, it was shown that Pt3G decreased the mitochondrial membrane permeability through regulating the expressions of Bax and Bcl-2. Western blot analysis indicated that Pt3G significantly increased the expression of PTEN and then activated the PI3K/Akt-mediated caspase 3 pathway. In addition, our results also suggested that Pt3G activated the PTEN gene to induce the apoptosis of DU-145 cells by stimulating the overproduction of ROS. To sum up, these results indicate that Pt3G inhibits cell proliferation and induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells. Therefore, Pt3G of Lycium ruthenicum Murray may be a potential anti-proliferative agent for the prevention or treatment of prostate cancer.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>33527955</pmid><doi>10.1039/d0fo02382e</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-1353-1217</orcidid><orcidid>https://orcid.org/0000-0003-2954-3896</orcidid></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase AKT protein Anthocyanins Anthocyanins - isolation & purification Anthocyanins - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Bax protein Bcl-2 protein Biological effects Caspase 3 - metabolism Caspase-3 Cell cycle Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Flow cytometry Fruit - chemistry Glucosides - isolation & purification Glucosides - pharmacology Humans Lycium - chemistry Lycium ruthenicum Male Membrane permeability Membrane Potential, Mitochondrial - drug effects Mitochondria Monomers Phosphatidylinositol 3-Kinases - metabolism Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - prevention & control Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - metabolism PTEN protein Reactive Oxygen Species - metabolism S phase Signal transduction Signal Transduction - drug effects Signaling Western blotting |
| title | The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells |
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