DNA replication stress and emerging prospects for PARG inhibitors in ovarian cancer therapy

Poly (ADP-ribosyl)ation has central functions in maintaining genome stability, including facilitating DNA replication and repair. In cancer cells these processes are frequently disrupted, and thus interfering with poly (ADP-ribosyl)ation can exacerbate inherent genome instability and induce selectiv...

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Veröffentlicht in:	Progress in biophysics and molecular biology 2021-08, Vol.163, p.160-170
Hauptverfasser:	Pillay, Nisha, Brady, Rosie M., Dey, Malini, Morgan, Robert D., Taylor, Stephen S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use DNA Replication Female Genomic Instability Humans Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Poly (ADP-ribose)glycohydolase Poly (ADP-ribosyl)ation Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Poly(ADP-ribose) Polymerases - therapeutic use Replication stress
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