Clinical correlation of cadherin‐17 marker with advanced tumor stages and poor prognosis of cholangiocarcinoma
Background and Objectives In this retrospective study, we examined the CA17 tissue expression and analyzed its clinical significance in cholangiocarcinoma (CCA). Materials and Methods Immunohistochemistry was performed to assess CA17 expression on tissue microarrays in a training cohort enrolling 12...
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| Veröffentlicht in: | Journal of surgical oncology 2021-04, Vol.123 (5), p.1253-1262 |
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| creator | Zheng, Bo‐Hao Shen, Sheng Wong, Kwong‐Fai Gong, Zi‐Jun Sun, Wen‐Tao Ni, Xiao‐Jian Wang, Ji‐Wen Hu, Mei‐Yu Liu, Han Ni, Xiao‐Ling Liu, Hou‐Bao Luk, John M. Suo, Tao |
| description | Background and Objectives
In this retrospective study, we examined the CA17 tissue expression and analyzed its clinical significance in cholangiocarcinoma (CCA).
Materials and Methods
Immunohistochemistry was performed to assess CA17 expression on tissue microarrays in a training cohort enrolling 120 CCA patients and a validation cohort comprising 60 CCA patients. Image pro plus was applied to score the staining intensity and expression level of CA17 marker. Kaplan‐Meier analysis, Cox's proportional hazards regression, and nomogram were applied to evaluate the prognostic significance of CA17.
Results
CA17 cancer biomarker over‐expression was significantly observed in CCA compared to their non‐tumor counterparts, and positively correlated with aggressive tumor phenotypes, like lymph node metastasis. Meanwhile, patients with high expression of CA17 correlated with worse postoperative overall survival (OS) and recurrence‐free survival. Besides, multivariate analysis identified that CA17 expression was an independent prognostic factor for cholangiocarcinoma patients, which indicated that the CA17 could be more efficient than serum CA19‐9 in predicting the OS of CCA patients. Notably, the nomogram integrating CA17 expression had better prognostic performance as compared with current TNM staging systems.
Conclusion
CA17 was an independent adverse prognostic factor for CCA patients’ survival, which may serve as a promising prognostic biomarker for CCA patients. |
| doi_str_mv | 10.1002/jso.26399 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2485512909</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2485512909</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3539-1eca789c9f8930a317e197a026d26538b39bed1d7b6ac4e15be3cdb14d0dfac13</originalsourceid><addsrcrecordid>eNp1kUtOHDEURa0oKDQkg2wgspQJDAr8qZ-HUSt8IiQGScbWK_tVtztVdseuCmLGElgjK8HQhEGkjKwnHx1d3UvIR85OOGPidJPCiailUm_IgjNVF4qp9i1Z5D9RlI1i--QgpQ1jTKm6fEf2paxEKbhckO1ycN4ZGKgJMeIAkwuehp4asGuMzj_c3fOGjhB_YaQ3blpTsH_AG7R0mscQaZpghYmCt3Qb8r2NYeVDcunZsg4D-JULBqJxPozwnuz1MCT88PIekp9nX38sL4qr6_PL5ZerwshKqoKjgaZVRvWtkgwkb5CrBpioragr2XZSdWi5bboaTIm86lAa2_HSMtuD4fKQHO28Oc_vGdOkR5cMDjkOhjlpUbZVxUVuKqOf_0E3YY4-p9OiYrytlWqrTB3vKBNDShF7vY0u93KrOdNPM-g8g36eIbOfXoxzN6J9Jf_2noHTHXDjBrz9v0l_-369Uz4CwrST2A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2501869985</pqid></control><display><type>article</type><title>Clinical correlation of cadherin‐17 marker with advanced tumor stages and poor prognosis of cholangiocarcinoma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Zheng, Bo‐Hao ; Shen, Sheng ; Wong, Kwong‐Fai ; Gong, Zi‐Jun ; Sun, Wen‐Tao ; Ni, Xiao‐Jian ; Wang, Ji‐Wen ; Hu, Mei‐Yu ; Liu, Han ; Ni, Xiao‐Ling ; Liu, Hou‐Bao ; Luk, John M. ; Suo, Tao</creator><creatorcontrib>Zheng, Bo‐Hao ; Shen, Sheng ; Wong, Kwong‐Fai ; Gong, Zi‐Jun ; Sun, Wen‐Tao ; Ni, Xiao‐Jian ; Wang, Ji‐Wen ; Hu, Mei‐Yu ; Liu, Han ; Ni, Xiao‐Ling ; Liu, Hou‐Bao ; Luk, John M. ; Suo, Tao</creatorcontrib><description>Background and Objectives
In this retrospective study, we examined the CA17 tissue expression and analyzed its clinical significance in cholangiocarcinoma (CCA).
Materials and Methods
Immunohistochemistry was performed to assess CA17 expression on tissue microarrays in a training cohort enrolling 120 CCA patients and a validation cohort comprising 60 CCA patients. Image pro plus was applied to score the staining intensity and expression level of CA17 marker. Kaplan‐Meier analysis, Cox's proportional hazards regression, and nomogram were applied to evaluate the prognostic significance of CA17.
Results
CA17 cancer biomarker over‐expression was significantly observed in CCA compared to their non‐tumor counterparts, and positively correlated with aggressive tumor phenotypes, like lymph node metastasis. Meanwhile, patients with high expression of CA17 correlated with worse postoperative overall survival (OS) and recurrence‐free survival. Besides, multivariate analysis identified that CA17 expression was an independent prognostic factor for cholangiocarcinoma patients, which indicated that the CA17 could be more efficient than serum CA19‐9 in predicting the OS of CCA patients. Notably, the nomogram integrating CA17 expression had better prognostic performance as compared with current TNM staging systems.
Conclusion
CA17 was an independent adverse prognostic factor for CCA patients’ survival, which may serve as a promising prognostic biomarker for CCA patients.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.26399</identifier><identifier>PMID: 33524213</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bile Duct Neoplasms - metabolism ; Bile Duct Neoplasms - pathology ; Bile Duct Neoplasms - surgery ; Biomarkers ; Biomarkers, Tumor - metabolism ; Cadherins - metabolism ; cadherin‐17 ; Cancer ; Cholangiocarcinoma ; Cholangiocarcinoma - metabolism ; Cholangiocarcinoma - pathology ; Cholangiocarcinoma - surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Medical prognosis ; Middle Aged ; Neoplasm Recurrence, Local - metabolism ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - surgery ; nomogram ; Nomograms ; Prognosis ; Retrospective Studies ; Survival analysis ; Survival Rate</subject><ispartof>Journal of surgical oncology, 2021-04, Vol.123 (5), p.1253-1262</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-1eca789c9f8930a317e197a026d26538b39bed1d7b6ac4e15be3cdb14d0dfac13</citedby><cites>FETCH-LOGICAL-c3539-1eca789c9f8930a317e197a026d26538b39bed1d7b6ac4e15be3cdb14d0dfac13</cites><orcidid>0000-0003-0934-8209</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.26399$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.26399$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33524213$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Bo‐Hao</creatorcontrib><creatorcontrib>Shen, Sheng</creatorcontrib><creatorcontrib>Wong, Kwong‐Fai</creatorcontrib><creatorcontrib>Gong, Zi‐Jun</creatorcontrib><creatorcontrib>Sun, Wen‐Tao</creatorcontrib><creatorcontrib>Ni, Xiao‐Jian</creatorcontrib><creatorcontrib>Wang, Ji‐Wen</creatorcontrib><creatorcontrib>Hu, Mei‐Yu</creatorcontrib><creatorcontrib>Liu, Han</creatorcontrib><creatorcontrib>Ni, Xiao‐Ling</creatorcontrib><creatorcontrib>Liu, Hou‐Bao</creatorcontrib><creatorcontrib>Luk, John M.</creatorcontrib><creatorcontrib>Suo, Tao</creatorcontrib><title>Clinical correlation of cadherin‐17 marker with advanced tumor stages and poor prognosis of cholangiocarcinoma</title><title>Journal of surgical oncology</title><addtitle>J Surg Oncol</addtitle><description>Background and Objectives
In this retrospective study, we examined the CA17 tissue expression and analyzed its clinical significance in cholangiocarcinoma (CCA).
Materials and Methods
Immunohistochemistry was performed to assess CA17 expression on tissue microarrays in a training cohort enrolling 120 CCA patients and a validation cohort comprising 60 CCA patients. Image pro plus was applied to score the staining intensity and expression level of CA17 marker. Kaplan‐Meier analysis, Cox's proportional hazards regression, and nomogram were applied to evaluate the prognostic significance of CA17.
Results
CA17 cancer biomarker over‐expression was significantly observed in CCA compared to their non‐tumor counterparts, and positively correlated with aggressive tumor phenotypes, like lymph node metastasis. Meanwhile, patients with high expression of CA17 correlated with worse postoperative overall survival (OS) and recurrence‐free survival. Besides, multivariate analysis identified that CA17 expression was an independent prognostic factor for cholangiocarcinoma patients, which indicated that the CA17 could be more efficient than serum CA19‐9 in predicting the OS of CCA patients. Notably, the nomogram integrating CA17 expression had better prognostic performance as compared with current TNM staging systems.
Conclusion
CA17 was an independent adverse prognostic factor for CCA patients’ survival, which may serve as a promising prognostic biomarker for CCA patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bile Duct Neoplasms - metabolism</subject><subject>Bile Duct Neoplasms - pathology</subject><subject>Bile Duct Neoplasms - surgery</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cadherins - metabolism</subject><subject>cadherin‐17</subject><subject>Cancer</subject><subject>Cholangiocarcinoma</subject><subject>Cholangiocarcinoma - metabolism</subject><subject>Cholangiocarcinoma - pathology</subject><subject>Cholangiocarcinoma - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - metabolism</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>nomogram</subject><subject>Nomograms</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Survival analysis</subject><subject>Survival Rate</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtOHDEURa0oKDQkg2wgspQJDAr8qZ-HUSt8IiQGScbWK_tVtztVdseuCmLGElgjK8HQhEGkjKwnHx1d3UvIR85OOGPidJPCiailUm_IgjNVF4qp9i1Z5D9RlI1i--QgpQ1jTKm6fEf2paxEKbhckO1ycN4ZGKgJMeIAkwuehp4asGuMzj_c3fOGjhB_YaQ3blpTsH_AG7R0mscQaZpghYmCt3Qb8r2NYeVDcunZsg4D-JULBqJxPozwnuz1MCT88PIekp9nX38sL4qr6_PL5ZerwshKqoKjgaZVRvWtkgwkb5CrBpioragr2XZSdWi5bboaTIm86lAa2_HSMtuD4fKQHO28Oc_vGdOkR5cMDjkOhjlpUbZVxUVuKqOf_0E3YY4-p9OiYrytlWqrTB3vKBNDShF7vY0u93KrOdNPM-g8g36eIbOfXoxzN6J9Jf_2noHTHXDjBrz9v0l_-369Uz4CwrST2A</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Zheng, Bo‐Hao</creator><creator>Shen, Sheng</creator><creator>Wong, Kwong‐Fai</creator><creator>Gong, Zi‐Jun</creator><creator>Sun, Wen‐Tao</creator><creator>Ni, Xiao‐Jian</creator><creator>Wang, Ji‐Wen</creator><creator>Hu, Mei‐Yu</creator><creator>Liu, Han</creator><creator>Ni, Xiao‐Ling</creator><creator>Liu, Hou‐Bao</creator><creator>Luk, John M.</creator><creator>Suo, Tao</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0934-8209</orcidid></search><sort><creationdate>20210401</creationdate><title>Clinical correlation of cadherin‐17 marker with advanced tumor stages and poor prognosis of cholangiocarcinoma</title><author>Zheng, Bo‐Hao ; Shen, Sheng ; Wong, Kwong‐Fai ; Gong, Zi‐Jun ; Sun, Wen‐Tao ; Ni, Xiao‐Jian ; Wang, Ji‐Wen ; Hu, Mei‐Yu ; Liu, Han ; Ni, Xiao‐Ling ; Liu, Hou‐Bao ; Luk, John M. ; Suo, Tao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-1eca789c9f8930a317e197a026d26538b39bed1d7b6ac4e15be3cdb14d0dfac13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bile Duct Neoplasms - metabolism</topic><topic>Bile Duct Neoplasms - pathology</topic><topic>Bile Duct Neoplasms - surgery</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cadherins - metabolism</topic><topic>cadherin‐17</topic><topic>Cancer</topic><topic>Cholangiocarcinoma</topic><topic>Cholangiocarcinoma - metabolism</topic><topic>Cholangiocarcinoma - pathology</topic><topic>Cholangiocarcinoma - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - metabolism</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>nomogram</topic><topic>Nomograms</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Survival analysis</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Bo‐Hao</creatorcontrib><creatorcontrib>Shen, Sheng</creatorcontrib><creatorcontrib>Wong, Kwong‐Fai</creatorcontrib><creatorcontrib>Gong, Zi‐Jun</creatorcontrib><creatorcontrib>Sun, Wen‐Tao</creatorcontrib><creatorcontrib>Ni, Xiao‐Jian</creatorcontrib><creatorcontrib>Wang, Ji‐Wen</creatorcontrib><creatorcontrib>Hu, Mei‐Yu</creatorcontrib><creatorcontrib>Liu, Han</creatorcontrib><creatorcontrib>Ni, Xiao‐Ling</creatorcontrib><creatorcontrib>Liu, Hou‐Bao</creatorcontrib><creatorcontrib>Luk, John M.</creatorcontrib><creatorcontrib>Suo, Tao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Bo‐Hao</au><au>Shen, Sheng</au><au>Wong, Kwong‐Fai</au><au>Gong, Zi‐Jun</au><au>Sun, Wen‐Tao</au><au>Ni, Xiao‐Jian</au><au>Wang, Ji‐Wen</au><au>Hu, Mei‐Yu</au><au>Liu, Han</au><au>Ni, Xiao‐Ling</au><au>Liu, Hou‐Bao</au><au>Luk, John M.</au><au>Suo, Tao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical correlation of cadherin‐17 marker with advanced tumor stages and poor prognosis of cholangiocarcinoma</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J Surg Oncol</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>123</volume><issue>5</issue><spage>1253</spage><epage>1262</epage><pages>1253-1262</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background and Objectives
In this retrospective study, we examined the CA17 tissue expression and analyzed its clinical significance in cholangiocarcinoma (CCA).
Materials and Methods
Immunohistochemistry was performed to assess CA17 expression on tissue microarrays in a training cohort enrolling 120 CCA patients and a validation cohort comprising 60 CCA patients. Image pro plus was applied to score the staining intensity and expression level of CA17 marker. Kaplan‐Meier analysis, Cox's proportional hazards regression, and nomogram were applied to evaluate the prognostic significance of CA17.
Results
CA17 cancer biomarker over‐expression was significantly observed in CCA compared to their non‐tumor counterparts, and positively correlated with aggressive tumor phenotypes, like lymph node metastasis. Meanwhile, patients with high expression of CA17 correlated with worse postoperative overall survival (OS) and recurrence‐free survival. Besides, multivariate analysis identified that CA17 expression was an independent prognostic factor for cholangiocarcinoma patients, which indicated that the CA17 could be more efficient than serum CA19‐9 in predicting the OS of CCA patients. Notably, the nomogram integrating CA17 expression had better prognostic performance as compared with current TNM staging systems.
Conclusion
CA17 was an independent adverse prognostic factor for CCA patients’ survival, which may serve as a promising prognostic biomarker for CCA patients.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33524213</pmid><doi>10.1002/jso.26399</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0934-8209</orcidid></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Bile Duct Neoplasms - metabolism Bile Duct Neoplasms - pathology Bile Duct Neoplasms - surgery Biomarkers Biomarkers, Tumor - metabolism Cadherins - metabolism cadherin‐17 Cancer Cholangiocarcinoma Cholangiocarcinoma - metabolism Cholangiocarcinoma - pathology Cholangiocarcinoma - surgery Female Follow-Up Studies Humans Male Medical prognosis Middle Aged Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery nomogram Nomograms Prognosis Retrospective Studies Survival analysis Survival Rate |
| title | Clinical correlation of cadherin‐17 marker with advanced tumor stages and poor prognosis of cholangiocarcinoma |
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