Simultaneous Determination of Five Bile Acids as Potential Biomarkers for Alzheimer’s Disease in Mouse Brain and Plasma

In this study, we developed an analytical method using LC-MS/MS for the simultaneous determination of five bile acids (BAs) that have been recently reported as candidate diagnostic biomarkers for Alzheimer’s disease (AD) or AD related factors in the brain. The measurement of BAs in the brains of hea...

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Veröffentlicht in:	Analytical Sciences 2021/08/10, Vol.37(8), pp.1165-1170
Hauptverfasser:	KOIKE, Shin, MIYAJI, Yusuke, SANO, Hinako, AIKAWA, Natsuki, KAI, Masayuki, KASAHARA, Sakura, SUZUKI, Toshihiro, NISHIMOTO-KUSUNOSE, Shoichi, OGASAWARA, Yuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Alzheimer Disease - diagnosis Alzheimer's disease Analytical Chemistry Animal models Animals Bile bile acid Bile acids Bile Acids and Salts biomarker Biomarkers Brain Chemistry Chenodeoxycholic acid Cholic acid Chromatography, Liquid Deoxycholic acid Diagnostic systems LC-MS/MS Mice mouse brain Neurodegenerative diseases Original Paper Signs and symptoms simultaneous determination Tandem Mass Spectrometry
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