Simultaneous Determination of Five Bile Acids as Potential Biomarkers for Alzheimer’s Disease in Mouse Brain and Plasma
In this study, we developed an analytical method using LC-MS/MS for the simultaneous determination of five bile acids (BAs) that have been recently reported as candidate diagnostic biomarkers for Alzheimer’s disease (AD) or AD related factors in the brain. The measurement of BAs in the brains of hea...
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| Veröffentlicht in: | Analytical Sciences 2021/08/10, Vol.37(8), pp.1165-1170 |
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| creator | KOIKE, Shin MIYAJI, Yusuke SANO, Hinako AIKAWA, Natsuki KAI, Masayuki KASAHARA, Sakura SUZUKI, Toshihiro NISHIMOTO-KUSUNOSE, Shoichi OGASAWARA, Yuki |
| description | In this study, we developed an analytical method using LC-MS/MS for the simultaneous determination of five bile acids (BAs) that have been recently reported as candidate diagnostic biomarkers for Alzheimer’s disease (AD) or AD related factors in the brain. The measurement of BAs in the brains of healthy mice led to the determination of candidate diagnostic markers for AD, such as cholic acid and deoxycholic acid, and other bile acids, such as chenodeoxycholic acid noted for the ameliorating effect on the symptoms of AD. Significant positive correlations were observed between the brain and plasma concentrations of four BAs in healthy young mice. These results indicate that the BA level in the brain may be estimated by the corresponding BA level in the plasma. Thus, our study suggested that the proposed method for the analysis of the five bile acids would aid in the diagnosis of AD or in studies that use AD model mice. |
| doi_str_mv | 10.2116/analsci.20P429 |
| format | Article |
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The measurement of BAs in the brains of healthy mice led to the determination of candidate diagnostic markers for AD, such as cholic acid and deoxycholic acid, and other bile acids, such as chenodeoxycholic acid noted for the ameliorating effect on the symptoms of AD. Significant positive correlations were observed between the brain and plasma concentrations of four BAs in healthy young mice. These results indicate that the BA level in the brain may be estimated by the corresponding BA level in the plasma. Thus, our study suggested that the proposed method for the analysis of the five bile acids would aid in the diagnosis of AD or in studies that use AD model mice.</description><identifier>ISSN: 0910-6340</identifier><identifier>EISSN: 1348-2246</identifier><identifier>DOI: 10.2116/analsci.20P429</identifier><identifier>PMID: 33518588</identifier><language>eng</language><publisher>Singapore: The Japan Society for Analytical Chemistry</publisher><subject>Acids ; Alzheimer Disease - diagnosis ; Alzheimer's disease ; Analytical Chemistry ; Animal models ; Animals ; Bile ; bile acid ; Bile acids ; Bile Acids and Salts ; biomarker ; Biomarkers ; Brain ; Chemistry ; Chenodeoxycholic acid ; Cholic acid ; Chromatography, Liquid ; Deoxycholic acid ; Diagnostic systems ; LC-MS/MS ; Mice ; mouse brain ; Neurodegenerative diseases ; Original Paper ; Signs and symptoms ; simultaneous determination ; Tandem Mass Spectrometry</subject><ispartof>Analytical Sciences, 2021/08/10, Vol.37(8), pp.1165-1170</ispartof><rights>2021 by The Japan Society for Analytical Chemistry</rights><rights>The Japan Society for Analytical Chemistry 2021</rights><rights>Copyright Japan Science and Technology Agency 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c682t-e9f36c275225e7d4b05a914e4a86762422ae65ff65e541f395ba82b70db385e73</citedby><cites>FETCH-LOGICAL-c682t-e9f36c275225e7d4b05a914e4a86762422ae65ff65e541f395ba82b70db385e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.2116/analsci.20P429$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.2116/analsci.20P429$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,1883,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33518588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOIKE, Shin</creatorcontrib><creatorcontrib>MIYAJI, Yusuke</creatorcontrib><creatorcontrib>SANO, Hinako</creatorcontrib><creatorcontrib>AIKAWA, Natsuki</creatorcontrib><creatorcontrib>KAI, Masayuki</creatorcontrib><creatorcontrib>KASAHARA, Sakura</creatorcontrib><creatorcontrib>SUZUKI, Toshihiro</creatorcontrib><creatorcontrib>NISHIMOTO-KUSUNOSE, Shoichi</creatorcontrib><creatorcontrib>OGASAWARA, Yuki</creatorcontrib><title>Simultaneous Determination of Five Bile Acids as Potential Biomarkers for Alzheimer’s Disease in Mouse Brain and Plasma</title><title>Analytical Sciences</title><addtitle>ANAL. SCI</addtitle><addtitle>Anal Sci</addtitle><description>In this study, we developed an analytical method using LC-MS/MS for the simultaneous determination of five bile acids (BAs) that have been recently reported as candidate diagnostic biomarkers for Alzheimer’s disease (AD) or AD related factors in the brain. The measurement of BAs in the brains of healthy mice led to the determination of candidate diagnostic markers for AD, such as cholic acid and deoxycholic acid, and other bile acids, such as chenodeoxycholic acid noted for the ameliorating effect on the symptoms of AD. Significant positive correlations were observed between the brain and plasma concentrations of four BAs in healthy young mice. These results indicate that the BA level in the brain may be estimated by the corresponding BA level in the plasma. Thus, our study suggested that the proposed method for the analysis of the five bile acids would aid in the diagnosis of AD or in studies that use AD model mice.</description><subject>Acids</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer's disease</subject><subject>Analytical Chemistry</subject><subject>Animal models</subject><subject>Animals</subject><subject>Bile</subject><subject>bile acid</subject><subject>Bile acids</subject><subject>Bile Acids and Salts</subject><subject>biomarker</subject><subject>Biomarkers</subject><subject>Brain</subject><subject>Chemistry</subject><subject>Chenodeoxycholic acid</subject><subject>Cholic acid</subject><subject>Chromatography, Liquid</subject><subject>Deoxycholic acid</subject><subject>Diagnostic systems</subject><subject>LC-MS/MS</subject><subject>Mice</subject><subject>mouse brain</subject><subject>Neurodegenerative diseases</subject><subject>Original Paper</subject><subject>Signs and symptoms</subject><subject>simultaneous determination</subject><subject>Tandem Mass Spectrometry</subject><issn>0910-6340</issn><issn>1348-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS0EokNhyxJZYtNNpv6PsxxaCkhFjASsrZvkpvXgJMVOkMqK1-D1eBI8yjBISCz8I9_vHNv3EPKcs7Xg3JzDACE1fi3YVonqAVlxqWwhhDIPyYpVnBVGKnZCnqS0Y4wLK8RjciKl5lZbuyL3H30_hwkGHOdEL3HC2PsBJj8OdOzolf-G9JUPSDeNbxOFRLfjhMPkIeTzsYf4BWOi3RjpJny_Rd9j_PXjZ7byCSEh9QN9n62zS4S8h6Gl2wCph6fkUZffjs8O6yn5fPX608Xb4vrDm3cXm-uiMVZMBVadNI0otRAay1bVTEPFFSqwpjRCCQFodNcZjVrxTla6BivqkrW1tFkhT8nZ4nsXx68zpsn1PjUYwvJnJ5RVeXDFMvryH3Q3znHfYSe0sZKxsjKZWi9UE8eUInbuLvrciHvHmduH4g6huCWULHhxsJ3rHtsj_ieFDJwvQMql4Qbj33v_a3m5KHZpghs8WkKcfBPwiMvS2f20yI7l5haiw0H-BjSbsqY</recordid><startdate>20210810</startdate><enddate>20210810</enddate><creator>KOIKE, Shin</creator><creator>MIYAJI, Yusuke</creator><creator>SANO, Hinako</creator><creator>AIKAWA, Natsuki</creator><creator>KAI, Masayuki</creator><creator>KASAHARA, Sakura</creator><creator>SUZUKI, Toshihiro</creator><creator>NISHIMOTO-KUSUNOSE, Shoichi</creator><creator>OGASAWARA, Yuki</creator><general>The Japan Society for Analytical Chemistry</general><general>Springer Nature Singapore</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>L7M</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20210810</creationdate><title>Simultaneous Determination of Five Bile Acids as Potential Biomarkers for Alzheimer’s Disease in Mouse Brain and Plasma</title><author>KOIKE, Shin ; MIYAJI, Yusuke ; SANO, Hinako ; AIKAWA, Natsuki ; KAI, Masayuki ; KASAHARA, Sakura ; SUZUKI, Toshihiro ; NISHIMOTO-KUSUNOSE, Shoichi ; OGASAWARA, Yuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c682t-e9f36c275225e7d4b05a914e4a86762422ae65ff65e541f395ba82b70db385e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acids</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer's disease</topic><topic>Analytical Chemistry</topic><topic>Animal models</topic><topic>Animals</topic><topic>Bile</topic><topic>bile acid</topic><topic>Bile acids</topic><topic>Bile Acids and Salts</topic><topic>biomarker</topic><topic>Biomarkers</topic><topic>Brain</topic><topic>Chemistry</topic><topic>Chenodeoxycholic acid</topic><topic>Cholic acid</topic><topic>Chromatography, Liquid</topic><topic>Deoxycholic acid</topic><topic>Diagnostic systems</topic><topic>LC-MS/MS</topic><topic>Mice</topic><topic>mouse brain</topic><topic>Neurodegenerative diseases</topic><topic>Original Paper</topic><topic>Signs and symptoms</topic><topic>simultaneous determination</topic><topic>Tandem Mass Spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOIKE, Shin</creatorcontrib><creatorcontrib>MIYAJI, Yusuke</creatorcontrib><creatorcontrib>SANO, Hinako</creatorcontrib><creatorcontrib>AIKAWA, Natsuki</creatorcontrib><creatorcontrib>KAI, Masayuki</creatorcontrib><creatorcontrib>KASAHARA, Sakura</creatorcontrib><creatorcontrib>SUZUKI, Toshihiro</creatorcontrib><creatorcontrib>NISHIMOTO-KUSUNOSE, Shoichi</creatorcontrib><creatorcontrib>OGASAWARA, Yuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOIKE, Shin</au><au>MIYAJI, Yusuke</au><au>SANO, Hinako</au><au>AIKAWA, Natsuki</au><au>KAI, Masayuki</au><au>KASAHARA, Sakura</au><au>SUZUKI, Toshihiro</au><au>NISHIMOTO-KUSUNOSE, Shoichi</au><au>OGASAWARA, Yuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous Determination of Five Bile Acids as Potential Biomarkers for Alzheimer’s Disease in Mouse Brain and Plasma</atitle><jtitle>Analytical Sciences</jtitle><stitle>ANAL. SCI</stitle><addtitle>Anal Sci</addtitle><date>2021-08-10</date><risdate>2021</risdate><volume>37</volume><issue>8</issue><spage>1165</spage><epage>1170</epage><pages>1165-1170</pages><issn>0910-6340</issn><eissn>1348-2246</eissn><abstract>In this study, we developed an analytical method using LC-MS/MS for the simultaneous determination of five bile acids (BAs) that have been recently reported as candidate diagnostic biomarkers for Alzheimer’s disease (AD) or AD related factors in the brain. The measurement of BAs in the brains of healthy mice led to the determination of candidate diagnostic markers for AD, such as cholic acid and deoxycholic acid, and other bile acids, such as chenodeoxycholic acid noted for the ameliorating effect on the symptoms of AD. Significant positive correlations were observed between the brain and plasma concentrations of four BAs in healthy young mice. 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| subjects | Acids Alzheimer Disease - diagnosis Alzheimer's disease Analytical Chemistry Animal models Animals Bile bile acid Bile acids Bile Acids and Salts biomarker Biomarkers Brain Chemistry Chenodeoxycholic acid Cholic acid Chromatography, Liquid Deoxycholic acid Diagnostic systems LC-MS/MS Mice mouse brain Neurodegenerative diseases Original Paper Signs and symptoms simultaneous determination Tandem Mass Spectrometry |
| title | Simultaneous Determination of Five Bile Acids as Potential Biomarkers for Alzheimer’s Disease in Mouse Brain and Plasma |
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