Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest

•ERK and calpain-2 are activated in cerebral ischemia–reperfusion injury cases.•Neuroinflammation and necroptosis are involved in CIRI induced by CA/CPR.•PD98059 and MDL28170 can inhibit the ERK/calpain-2 pathway.•Inhibition of ERK/calpain-2 can reduce neuroinflammation and necroptosis after CIRI. C...

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Veröffentlicht in:	International immunopharmacology 2021-04, Vol.93, p.107377-107377, Article 107377
Hauptverfasser:	Wang, Wen-yan, Xie, Lu, Zou, Xin-sen, Li, Nuo, Yang, Ye-gui, Wu, Zhi-jiang, Tian, Xin-yue, Zhao, Gao-yang, Chen, Meng-hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Ischemia - immunology Calpain - antagonists & inhibitors Calpain - immunology Cardiopulmonary resuscitation Dipeptides - pharmacology Disease Models, Animal Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - immunology Flavonoids - pharmacology Fluorescent multiplex immunohistochemistry Heart Arrest - immunology Inflammation - immunology Male MDL28170 MLKL Necroptosis PD98059 Rats Rats, Sprague-Dawley Reperfusion Injury - immunology Signal Transduction
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