ASIC1 inhibition impairs the proliferation and migration of pancreatic stellate cells induced by pancreatic cancer cells

Activated pancreatic stellate cells (PSCs) with an increased proliferation and migration ability are the partners in crime with pancreatic cancer cells. Acid-sensing ion channel 1 (ASIC1) is expressed in pancreatic cancer and PSCs, and especially, it mediates the activation of PSCs. However, whether...

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Veröffentlicht in:	Neoplasma 2021-01, Vol.68 (1), p.174-179
Hauptverfasser:	Zhu, Lei, Yin, Jianmei, Zheng, Fuhong, Ji, Lianfeng, Yu, Yingqing, Liu, Haibo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Sensing Ion Channel Blockers Acid Sensing Ion Channels - metabolism Cell Line, Tumor Cell Proliferation - drug effects Humans MAP Kinase Signaling System Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pancreatic Stellate Cells - metabolism Pancreatic Stellate Cells - pathology Phosphorylation
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