The effect of adding L-Carnitine to the GnRH-antagonist protocol on assisted reproductive technology outcome in women with polycystic ovarian syndrome: a randomized clinical trial
This study aimed to investigate the effect of adding L-Carnitine to the gonadotropins on ART outcome in frozen-thawed embryo transfer cycles among PCOS women. In this randomized clinical trial, 83 patients with PCOS were randomized to either L-Carnitine supplemented (n = 42) or control (n = 41) grou...
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| Veröffentlicht in: | Gynecological endocrinology 2023-12, Vol.39 (1), p.1878135-1878135 |
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| container_title | Gynecological endocrinology |
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| creator | Sheida, Arezoo Davar, Robab Tabibnejad, Nasim Eftekhar, Maryam |
| description | This study aimed to investigate the effect of adding L-Carnitine to the gonadotropins on ART outcome in frozen-thawed embryo transfer cycles among PCOS women.
In this randomized clinical trial, 83 patients with PCOS were randomized to either L-Carnitine supplemented (n = 42) or control (n = 41) groups. The L-Carnitine group was given 3000 mg of oral L-Carnitine daily until the final day of ovulation. The numbers of metaphase II (MII) oocytes, 2-pronuclears (2PNs), oocyte maturity rate, fertilization rate, fertilization proportion as well as implantation, chemical and clinical pregnancy rates were compared between the two groups.
Even though the duration of stimulation and endometrial thickness were comparable between groups (p > .05), serum estradiol level on the day of oocyte triggering, was significantly higher in the L-Carnitine group compared to the control group (p .05). Moreover, oocyte maturity rate (0.85 ± 0.38 vs. 1.02 ± 0.90), fertilization proportion (0.62 ± 0.44 vs. 0.80 ± 0.86), fertilization rate (0.70 ± 0.22 vs. 0.76 ± 0.19) along with implantation rate (18.1 vs. 13.7%), chemical (26.8 vs. 30.7%) and clinical (24.3 vs. 25.6%) pregnancy rates, were all comparable between L-Carnitine and control groups respectively (p > .05).
Our result showed that oral L-Carnitine administration during induction of ovulation among PCOS women could not improve laboratory and pregnancy outcome. |
| doi_str_mv | 10.1080/09513590.2021.1878135 |
| format | Article |
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In this randomized clinical trial, 83 patients with PCOS were randomized to either L-Carnitine supplemented (n = 42) or control (n = 41) groups. The L-Carnitine group was given 3000 mg of oral L-Carnitine daily until the final day of ovulation. The numbers of metaphase II (MII) oocytes, 2-pronuclears (2PNs), oocyte maturity rate, fertilization rate, fertilization proportion as well as implantation, chemical and clinical pregnancy rates were compared between the two groups.
Even though the duration of stimulation and endometrial thickness were comparable between groups (p > .05), serum estradiol level on the day of oocyte triggering, was significantly higher in the L-Carnitine group compared to the control group (p < .05). In contrast, the number of retrieved and MII oocytes as well as the number of 2PNs and obtained embryos were similar between groups (p > .05). Moreover, oocyte maturity rate (0.85 ± 0.38 vs. 1.02 ± 0.90), fertilization proportion (0.62 ± 0.44 vs. 0.80 ± 0.86), fertilization rate (0.70 ± 0.22 vs. 0.76 ± 0.19) along with implantation rate (18.1 vs. 13.7%), chemical (26.8 vs. 30.7%) and clinical (24.3 vs. 25.6%) pregnancy rates, were all comparable between L-Carnitine and control groups respectively (p > .05).
Our result showed that oral L-Carnitine administration during induction of ovulation among PCOS women could not improve laboratory and pregnancy outcome.</description><identifier>ISSN: 0951-3590</identifier><identifier>EISSN: 1473-0766</identifier><identifier>DOI: 10.1080/09513590.2021.1878135</identifier><identifier>PMID: 33517804</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Carnitine - therapeutic use ; Female ; Gonadotropin-Releasing Hormone ; Humans ; IVF ; L-Carnitine ; Ovulation Induction - methods ; Polycystic ovarian syndrome ; Polycystic Ovary Syndrome - complications ; Polycystic Ovary Syndrome - drug therapy ; Pregnancy ; pregnancy rate ; Randomized Controlled Trials as Topic ; Reproductive Techniques, Assisted</subject><ispartof>Gynecological endocrinology, 2023-12, Vol.39 (1), p.1878135-1878135</ispartof><rights>2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-4e709f3f6bfa145f454c2b9928d17d088bc9248680108384ca40f5b033d450593</citedby><cites>FETCH-LOGICAL-c479t-4e709f3f6bfa145f454c2b9928d17d088bc9248680108384ca40f5b033d450593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09513590.2021.1878135$$EPDF$$P50$$Ginformaworld$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09513590.2021.1878135$$EHTML$$P50$$Ginformaworld$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,864,2100,27500,27922,27923,59141,59142</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33517804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sheida, Arezoo</creatorcontrib><creatorcontrib>Davar, Robab</creatorcontrib><creatorcontrib>Tabibnejad, Nasim</creatorcontrib><creatorcontrib>Eftekhar, Maryam</creatorcontrib><title>The effect of adding L-Carnitine to the GnRH-antagonist protocol on assisted reproductive technology outcome in women with polycystic ovarian syndrome: a randomized clinical trial</title><title>Gynecological endocrinology</title><addtitle>Gynecol Endocrinol</addtitle><description>This study aimed to investigate the effect of adding L-Carnitine to the gonadotropins on ART outcome in frozen-thawed embryo transfer cycles among PCOS women.
In this randomized clinical trial, 83 patients with PCOS were randomized to either L-Carnitine supplemented (n = 42) or control (n = 41) groups. The L-Carnitine group was given 3000 mg of oral L-Carnitine daily until the final day of ovulation. The numbers of metaphase II (MII) oocytes, 2-pronuclears (2PNs), oocyte maturity rate, fertilization rate, fertilization proportion as well as implantation, chemical and clinical pregnancy rates were compared between the two groups.
Even though the duration of stimulation and endometrial thickness were comparable between groups (p > .05), serum estradiol level on the day of oocyte triggering, was significantly higher in the L-Carnitine group compared to the control group (p < .05). In contrast, the number of retrieved and MII oocytes as well as the number of 2PNs and obtained embryos were similar between groups (p > .05). Moreover, oocyte maturity rate (0.85 ± 0.38 vs. 1.02 ± 0.90), fertilization proportion (0.62 ± 0.44 vs. 0.80 ± 0.86), fertilization rate (0.70 ± 0.22 vs. 0.76 ± 0.19) along with implantation rate (18.1 vs. 13.7%), chemical (26.8 vs. 30.7%) and clinical (24.3 vs. 25.6%) pregnancy rates, were all comparable between L-Carnitine and control groups respectively (p > .05).
Our result showed that oral L-Carnitine administration during induction of ovulation among PCOS women could not improve laboratory and pregnancy outcome.</description><subject>Carnitine - therapeutic use</subject><subject>Female</subject><subject>Gonadotropin-Releasing Hormone</subject><subject>Humans</subject><subject>IVF</subject><subject>L-Carnitine</subject><subject>Ovulation Induction - methods</subject><subject>Polycystic ovarian syndrome</subject><subject>Polycystic Ovary Syndrome - complications</subject><subject>Polycystic Ovary Syndrome - drug therapy</subject><subject>Pregnancy</subject><subject>pregnancy rate</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Reproductive Techniques, Assisted</subject><issn>0951-3590</issn><issn>1473-0766</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNp9kc9u1DAQxiMEokvhEUA-csliJ07icAKtoK20EhIqZ2v8b9eVYy-20yp9LV4QL7vtkYM9mtFvvhnNV1XvCV4TzPAnPHak7Ua8bnBD1oQNrKQvqhWhQ1vjoe9fVqsjUx-hi-pNSncYk5YOzevqom07MjBMV9Wf271G2hgtMwoGgVLW79C23kD0NluvUQ4oF-bK_7yuwWfYBW9TRocYcpDBoeARpFRKWqGoS1nNMtv70qjl3gcXdgsKc5Zh0sh69FBi-W3eo0Nwi1xSthKFe4gWPEqLV7EQnxGgCF6FyT4WXemstxIcyoVyb6tXBlzS787xsvr1_dvt5rre_ri62Xzd1pIOY66pHvBoWtMLA4R2hnZUNmIcG6bIoDBjQo4NZT3D5aAtoxIoNp3Abatoh7uxvaxuTroqwB0_RDtBXHgAy_8VQtxxiGV7p_mgRDNqCb0QjJYnmOyBagFEUM2kKlofT1rlQL9nnTKfbJLaOfA6zImXRSjpGzyygnYnVMaQUtTmeTTB_Og9f_KeH73nZ-9L34fziFlMWj13PZldgC8nwHoT4gQPITrFMywuRFOuLW3i7f9n_AUjGsHl</recordid><startdate>20231214</startdate><enddate>20231214</enddate><creator>Sheida, Arezoo</creator><creator>Davar, Robab</creator><creator>Tabibnejad, Nasim</creator><creator>Eftekhar, Maryam</creator><general>Taylor & Francis</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20231214</creationdate><title>The effect of adding L-Carnitine to the GnRH-antagonist protocol on assisted reproductive technology outcome in women with polycystic ovarian syndrome: a randomized clinical trial</title><author>Sheida, Arezoo ; Davar, Robab ; Tabibnejad, Nasim ; Eftekhar, Maryam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-4e709f3f6bfa145f454c2b9928d17d088bc9248680108384ca40f5b033d450593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Carnitine - therapeutic use</topic><topic>Female</topic><topic>Gonadotropin-Releasing Hormone</topic><topic>Humans</topic><topic>IVF</topic><topic>L-Carnitine</topic><topic>Ovulation Induction - methods</topic><topic>Polycystic ovarian syndrome</topic><topic>Polycystic Ovary Syndrome - complications</topic><topic>Polycystic Ovary Syndrome - drug therapy</topic><topic>Pregnancy</topic><topic>pregnancy rate</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Reproductive Techniques, Assisted</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sheida, Arezoo</creatorcontrib><creatorcontrib>Davar, Robab</creatorcontrib><creatorcontrib>Tabibnejad, Nasim</creatorcontrib><creatorcontrib>Eftekhar, Maryam</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Gynecological endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sheida, Arezoo</au><au>Davar, Robab</au><au>Tabibnejad, Nasim</au><au>Eftekhar, Maryam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of adding L-Carnitine to the GnRH-antagonist protocol on assisted reproductive technology outcome in women with polycystic ovarian syndrome: a randomized clinical trial</atitle><jtitle>Gynecological endocrinology</jtitle><addtitle>Gynecol Endocrinol</addtitle><date>2023-12-14</date><risdate>2023</risdate><volume>39</volume><issue>1</issue><spage>1878135</spage><epage>1878135</epage><pages>1878135-1878135</pages><issn>0951-3590</issn><eissn>1473-0766</eissn><abstract>This study aimed to investigate the effect of adding L-Carnitine to the gonadotropins on ART outcome in frozen-thawed embryo transfer cycles among PCOS women.
In this randomized clinical trial, 83 patients with PCOS were randomized to either L-Carnitine supplemented (n = 42) or control (n = 41) groups. The L-Carnitine group was given 3000 mg of oral L-Carnitine daily until the final day of ovulation. The numbers of metaphase II (MII) oocytes, 2-pronuclears (2PNs), oocyte maturity rate, fertilization rate, fertilization proportion as well as implantation, chemical and clinical pregnancy rates were compared between the two groups.
Even though the duration of stimulation and endometrial thickness were comparable between groups (p > .05), serum estradiol level on the day of oocyte triggering, was significantly higher in the L-Carnitine group compared to the control group (p < .05). In contrast, the number of retrieved and MII oocytes as well as the number of 2PNs and obtained embryos were similar between groups (p > .05). Moreover, oocyte maturity rate (0.85 ± 0.38 vs. 1.02 ± 0.90), fertilization proportion (0.62 ± 0.44 vs. 0.80 ± 0.86), fertilization rate (0.70 ± 0.22 vs. 0.76 ± 0.19) along with implantation rate (18.1 vs. 13.7%), chemical (26.8 vs. 30.7%) and clinical (24.3 vs. 25.6%) pregnancy rates, were all comparable between L-Carnitine and control groups respectively (p > .05).
Our result showed that oral L-Carnitine administration during induction of ovulation among PCOS women could not improve laboratory and pregnancy outcome.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>33517804</pmid><doi>10.1080/09513590.2021.1878135</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0951-3590 |
| ispartof | Gynecological endocrinology, 2023-12, Vol.39 (1), p.1878135-1878135 |
| issn | 0951-3590 1473-0766 |
| language | eng |
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| source | Taylor & Francis Open Access; MEDLINE; DOAJ Directory of Open Access Journals |
| subjects | Carnitine - therapeutic use Female Gonadotropin-Releasing Hormone Humans IVF L-Carnitine Ovulation Induction - methods Polycystic ovarian syndrome Polycystic Ovary Syndrome - complications Polycystic Ovary Syndrome - drug therapy Pregnancy pregnancy rate Randomized Controlled Trials as Topic Reproductive Techniques, Assisted |
| title | The effect of adding L-Carnitine to the GnRH-antagonist protocol on assisted reproductive technology outcome in women with polycystic ovarian syndrome: a randomized clinical trial |
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