Epigenomic features revealed by ATAC‐seq impact transgene expression in CHO cells

Different regions of a mammalian genome have different accessibilities to transcriptional machinery. The integration site of a transgene affects how actively it is transcribed. Highly accessible genomic regions called super‐enhancers have been recently described as strong regulatory elements that sh...

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Veröffentlicht in:	Biotechnology and bioengineering 2021-05, Vol.118 (5), p.1851-1861
Hauptverfasser:	Lee, Zion, Raabe, Marina, Hu, Wei‐Shou
Format:	Artikel
Sprache:	eng
Schlagworte:	Accessibility Animals ATAC‐seq Cell lines CHO CHO Cells Chromatin Chromatin Immunoprecipitation Sequencing - methods Cricetinae Cricetulus CRISPR-Cas Systems - genetics CRISPR/Cas9 Enhancer Elements, Genetic - genetics Enhancers Epigenesis, Genetic - genetics Gene sequencing Genes Genomes Immunoglobulin G Integration Olfaction Phenotypes Regulatory sequences Smell super‐enhancers Transcription Transgenes Transgenes - genetics Transposase
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