4D flow MRI left atrial kinetic energy in hypertrophic cardiomyopathy is associated with mitral regurgitation and left ventricular outflow tract obstruction
To noninvasively assess left atrial (LA) kinetic energy (KE) in hypertrophic cardiomyopathy (HCM) patients using 4D flow MRI and evaluate coupling associations with mitral regurgitation (MR) and left ventricular outflow tract (LVOT) obstruction. Twenty-nine retrospectively identified patients with H...
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| Veröffentlicht in: | The International Journal of Cardiovascular Imaging 2021-09, Vol.37 (9), p.2755-2765 |
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| creator | Gupta, Aakash N. Soulat, Gilles Avery, Ryan Allen, Bradley D. Collins, Jeremy D. Choudhury, Lubna Bonow, Robert O. Carr, James Markl, Michael Elbaz, Mohammed S. M. |
| description | To noninvasively assess left atrial (LA) kinetic energy (KE) in hypertrophic cardiomyopathy (HCM) patients using 4D flow MRI and evaluate coupling associations with mitral regurgitation (MR) and left ventricular outflow tract (LVOT) obstruction. Twenty-nine retrospectively identified patients with HCM underwent 4D flow MRI. MRI-estimated peak LVOT pressure gradient (∆P
MRI
) was used to classify patients into non-obstructive and obstructive HCM. Time-resolved volumetric LA kinetic energy (KE
LA
) was computed throughout systole. Average systolic (KE
LA-avg
) and peak systolic (KE
LA-peak
) KE
LA
were compared between non-obstructive and obstructive HCM groups, and associations to MR severity and LVOT ∆P
MRI
were tested.The study included 15 patients with non-obstructive HCM (58.6 [45.9, 65.2] years, 7 females) and 14 patients with obstructive HCM (51.9 [47.6, 62.6] years, 6 females). Obstructive HCM patients demonstrated significantly elevated instantaneous KE
LA
over all systolic time-points compared to non-obstructive HCM (P |
| doi_str_mv | 10.1007/s10554-021-02167-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2484152609</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2484152609</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-90342dd6cdc265069427e2fddb3eadaaa4ba6d3b855357510bb33c25e186ec743</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS0Eoj_wAiyQJTZsAv7PzRIVKJWKkBCsLcee3OuS2MF2qO678LA4TQGJBQvL1sw354x8EHpGyStKSPs6UyKlaAij61Ftox6gUypb3pBW8IfrW3WNbDtxgs5yviGEMML4Y3TCuWScK36Kfoq3eBjjLf74-QqPMBRsSvJmxN98gOIthgBpf8Q-4MNxhlRSnA-1bE1yPk7HOJtyqO2MTc7RelPA4VtfDnjyJVWdBPsl7X0xxceATXCbyw8I1ccuo0k4LuVuhcrbgmOfS1rsij9BjwYzZnh6f5-jr-_ffbn40Fx_ury6eHPdWN7K0nSEC-acss4yJYnqBGuBDc71HIwzxojeKMf7nZRctpKSvufcMgl0p8DWrzpHLzfdOcXvC-SiJ58tjKMJEJesmdgJKpkiXUVf_IPexCWFup1mUgnVMUpVpdhG2RRzTjDoOfnJpKOmRK_Z6S07XXPTd9npdej5vfTST-D-jPwOqwJ8A3JthT2kv97_kf0FK--oAg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2564692116</pqid></control><display><type>article</type><title>4D flow MRI left atrial kinetic energy in hypertrophic cardiomyopathy is associated with mitral regurgitation and left ventricular outflow tract obstruction</title><source>SpringerLink Journals - AutoHoldings</source><creator>Gupta, Aakash N. ; Soulat, Gilles ; Avery, Ryan ; Allen, Bradley D. ; Collins, Jeremy D. ; Choudhury, Lubna ; Bonow, Robert O. ; Carr, James ; Markl, Michael ; Elbaz, Mohammed S. M.</creator><creatorcontrib>Gupta, Aakash N. ; Soulat, Gilles ; Avery, Ryan ; Allen, Bradley D. ; Collins, Jeremy D. ; Choudhury, Lubna ; Bonow, Robert O. ; Carr, James ; Markl, Michael ; Elbaz, Mohammed S. M.</creatorcontrib><description><![CDATA[To noninvasively assess left atrial (LA) kinetic energy (KE) in hypertrophic cardiomyopathy (HCM) patients using 4D flow MRI and evaluate coupling associations with mitral regurgitation (MR) and left ventricular outflow tract (LVOT) obstruction. Twenty-nine retrospectively identified patients with HCM underwent 4D flow MRI. MRI-estimated peak LVOT pressure gradient (∆P
MRI
) was used to classify patients into non-obstructive and obstructive HCM. Time-resolved volumetric LA kinetic energy (KE
LA
) was computed throughout systole. Average systolic (KE
LA-avg
) and peak systolic (KE
LA-peak
) KE
LA
were compared between non-obstructive and obstructive HCM groups, and associations to MR severity and LVOT ∆P
MRI
were tested.The study included 15 patients with non-obstructive HCM (58.6 [45.9, 65.2] years, 7 females) and 14 patients with obstructive HCM (51.9 [47.6, 62.6] years, 6 females). Obstructive HCM patients demonstrated significantly elevated instantaneous KE
LA
over all systolic time-points compared to non-obstructive HCM (P < 0.05). Obstructive HCM patients also demonstrated higher KE
LA-avg
(14.8 [10.6, 20.4] J/m
3
vs. 33.4 [23.9, 61.3] J/m
3
, P < 0.001) and KE
LA-peak
(22.1 [15.9, 28.7] J/m
3
vs. 57.2 [44.5, 121.4] J/m
3
, P < 0.001) than non-obstructive HCM. MR severity was significantly correlated with KE
LA-avg
(rho = 0.81, P < 0.001) and KE
LA-peak
(rho = 0.79, P < 0.001). LVOT ∆P
MRI
was strongly correlated with KE
LA
metrics in obstructive HCM (KE
LA-avg
: rho = 0.86, P < 0.001; KE
LA-peak
: rho = 0.85, P < 0.001).In HCM patients, left atrial kinetic energy, by 4D flow MRI, is associated with MR severity and the degree of LVOT obstruction.]]></description><identifier>ISSN: 1569-5794</identifier><identifier>EISSN: 1573-0743</identifier><identifier>EISSN: 1875-8312</identifier><identifier>DOI: 10.1007/s10554-021-02167-6</identifier><identifier>PMID: 33523363</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Cardiac Imaging ; Cardiology ; Cardiomyopathy ; Energy ; Females ; Heart ; Imaging ; Kinetic energy ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Original Paper ; Outflow ; Radiology ; Regurgitation ; Systole ; Ventricle</subject><ispartof>The International Journal of Cardiovascular Imaging, 2021-09, Vol.37 (9), p.2755-2765</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-90342dd6cdc265069427e2fddb3eadaaa4ba6d3b855357510bb33c25e186ec743</citedby><cites>FETCH-LOGICAL-c375t-90342dd6cdc265069427e2fddb3eadaaa4ba6d3b855357510bb33c25e186ec743</cites><orcidid>0000-0001-5051-5668</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10554-021-02167-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10554-021-02167-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33523363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gupta, Aakash N.</creatorcontrib><creatorcontrib>Soulat, Gilles</creatorcontrib><creatorcontrib>Avery, Ryan</creatorcontrib><creatorcontrib>Allen, Bradley D.</creatorcontrib><creatorcontrib>Collins, Jeremy D.</creatorcontrib><creatorcontrib>Choudhury, Lubna</creatorcontrib><creatorcontrib>Bonow, Robert O.</creatorcontrib><creatorcontrib>Carr, James</creatorcontrib><creatorcontrib>Markl, Michael</creatorcontrib><creatorcontrib>Elbaz, Mohammed S. M.</creatorcontrib><title>4D flow MRI left atrial kinetic energy in hypertrophic cardiomyopathy is associated with mitral regurgitation and left ventricular outflow tract obstruction</title><title>The International Journal of Cardiovascular Imaging</title><addtitle>Int J Cardiovasc Imaging</addtitle><addtitle>Int J Cardiovasc Imaging</addtitle><description><![CDATA[To noninvasively assess left atrial (LA) kinetic energy (KE) in hypertrophic cardiomyopathy (HCM) patients using 4D flow MRI and evaluate coupling associations with mitral regurgitation (MR) and left ventricular outflow tract (LVOT) obstruction. Twenty-nine retrospectively identified patients with HCM underwent 4D flow MRI. MRI-estimated peak LVOT pressure gradient (∆P
MRI
) was used to classify patients into non-obstructive and obstructive HCM. Time-resolved volumetric LA kinetic energy (KE
LA
) was computed throughout systole. Average systolic (KE
LA-avg
) and peak systolic (KE
LA-peak
) KE
LA
were compared between non-obstructive and obstructive HCM groups, and associations to MR severity and LVOT ∆P
MRI
were tested.The study included 15 patients with non-obstructive HCM (58.6 [45.9, 65.2] years, 7 females) and 14 patients with obstructive HCM (51.9 [47.6, 62.6] years, 6 females). Obstructive HCM patients demonstrated significantly elevated instantaneous KE
LA
over all systolic time-points compared to non-obstructive HCM (P < 0.05). Obstructive HCM patients also demonstrated higher KE
LA-avg
(14.8 [10.6, 20.4] J/m
3
vs. 33.4 [23.9, 61.3] J/m
3
, P < 0.001) and KE
LA-peak
(22.1 [15.9, 28.7] J/m
3
vs. 57.2 [44.5, 121.4] J/m
3
, P < 0.001) than non-obstructive HCM. MR severity was significantly correlated with KE
LA-avg
(rho = 0.81, P < 0.001) and KE
LA-peak
(rho = 0.79, P < 0.001). LVOT ∆P
MRI
was strongly correlated with KE
LA
metrics in obstructive HCM (KE
LA-avg
: rho = 0.86, P < 0.001; KE
LA-peak
: rho = 0.85, P < 0.001).In HCM patients, left atrial kinetic energy, by 4D flow MRI, is associated with MR severity and the degree of LVOT obstruction.]]></description><subject>Cardiac Imaging</subject><subject>Cardiology</subject><subject>Cardiomyopathy</subject><subject>Energy</subject><subject>Females</subject><subject>Heart</subject><subject>Imaging</subject><subject>Kinetic energy</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Paper</subject><subject>Outflow</subject><subject>Radiology</subject><subject>Regurgitation</subject><subject>Systole</subject><subject>Ventricle</subject><issn>1569-5794</issn><issn>1573-0743</issn><issn>1875-8312</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kc1u1TAQhS0Eoj_wAiyQJTZsAv7PzRIVKJWKkBCsLcee3OuS2MF2qO678LA4TQGJBQvL1sw354x8EHpGyStKSPs6UyKlaAij61Ftox6gUypb3pBW8IfrW3WNbDtxgs5yviGEMML4Y3TCuWScK36Kfoq3eBjjLf74-QqPMBRsSvJmxN98gOIthgBpf8Q-4MNxhlRSnA-1bE1yPk7HOJtyqO2MTc7RelPA4VtfDnjyJVWdBPsl7X0xxceATXCbyw8I1ccuo0k4LuVuhcrbgmOfS1rsij9BjwYzZnh6f5-jr-_ffbn40Fx_ury6eHPdWN7K0nSEC-acss4yJYnqBGuBDc71HIwzxojeKMf7nZRctpKSvufcMgl0p8DWrzpHLzfdOcXvC-SiJ58tjKMJEJesmdgJKpkiXUVf_IPexCWFup1mUgnVMUpVpdhG2RRzTjDoOfnJpKOmRK_Z6S07XXPTd9npdej5vfTST-D-jPwOqwJ8A3JthT2kv97_kf0FK--oAg</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Gupta, Aakash N.</creator><creator>Soulat, Gilles</creator><creator>Avery, Ryan</creator><creator>Allen, Bradley D.</creator><creator>Collins, Jeremy D.</creator><creator>Choudhury, Lubna</creator><creator>Bonow, Robert O.</creator><creator>Carr, James</creator><creator>Markl, Michael</creator><creator>Elbaz, Mohammed S. M.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5051-5668</orcidid></search><sort><creationdate>20210901</creationdate><title>4D flow MRI left atrial kinetic energy in hypertrophic cardiomyopathy is associated with mitral regurgitation and left ventricular outflow tract obstruction</title><author>Gupta, Aakash N. ; Soulat, Gilles ; Avery, Ryan ; Allen, Bradley D. ; Collins, Jeremy D. ; Choudhury, Lubna ; Bonow, Robert O. ; Carr, James ; Markl, Michael ; Elbaz, Mohammed S. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-90342dd6cdc265069427e2fddb3eadaaa4ba6d3b855357510bb33c25e186ec743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cardiac Imaging</topic><topic>Cardiology</topic><topic>Cardiomyopathy</topic><topic>Energy</topic><topic>Females</topic><topic>Heart</topic><topic>Imaging</topic><topic>Kinetic energy</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Paper</topic><topic>Outflow</topic><topic>Radiology</topic><topic>Regurgitation</topic><topic>Systole</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gupta, Aakash N.</creatorcontrib><creatorcontrib>Soulat, Gilles</creatorcontrib><creatorcontrib>Avery, Ryan</creatorcontrib><creatorcontrib>Allen, Bradley D.</creatorcontrib><creatorcontrib>Collins, Jeremy D.</creatorcontrib><creatorcontrib>Choudhury, Lubna</creatorcontrib><creatorcontrib>Bonow, Robert O.</creatorcontrib><creatorcontrib>Carr, James</creatorcontrib><creatorcontrib>Markl, Michael</creatorcontrib><creatorcontrib>Elbaz, Mohammed S. M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>The International Journal of Cardiovascular Imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gupta, Aakash N.</au><au>Soulat, Gilles</au><au>Avery, Ryan</au><au>Allen, Bradley D.</au><au>Collins, Jeremy D.</au><au>Choudhury, Lubna</au><au>Bonow, Robert O.</au><au>Carr, James</au><au>Markl, Michael</au><au>Elbaz, Mohammed S. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>4D flow MRI left atrial kinetic energy in hypertrophic cardiomyopathy is associated with mitral regurgitation and left ventricular outflow tract obstruction</atitle><jtitle>The International Journal of Cardiovascular Imaging</jtitle><stitle>Int J Cardiovasc Imaging</stitle><addtitle>Int J Cardiovasc Imaging</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>37</volume><issue>9</issue><spage>2755</spage><epage>2765</epage><pages>2755-2765</pages><issn>1569-5794</issn><eissn>1573-0743</eissn><eissn>1875-8312</eissn><abstract><![CDATA[To noninvasively assess left atrial (LA) kinetic energy (KE) in hypertrophic cardiomyopathy (HCM) patients using 4D flow MRI and evaluate coupling associations with mitral regurgitation (MR) and left ventricular outflow tract (LVOT) obstruction. Twenty-nine retrospectively identified patients with HCM underwent 4D flow MRI. MRI-estimated peak LVOT pressure gradient (∆P
MRI
) was used to classify patients into non-obstructive and obstructive HCM. Time-resolved volumetric LA kinetic energy (KE
LA
) was computed throughout systole. Average systolic (KE
LA-avg
) and peak systolic (KE
LA-peak
) KE
LA
were compared between non-obstructive and obstructive HCM groups, and associations to MR severity and LVOT ∆P
MRI
were tested.The study included 15 patients with non-obstructive HCM (58.6 [45.9, 65.2] years, 7 females) and 14 patients with obstructive HCM (51.9 [47.6, 62.6] years, 6 females). Obstructive HCM patients demonstrated significantly elevated instantaneous KE
LA
over all systolic time-points compared to non-obstructive HCM (P < 0.05). Obstructive HCM patients also demonstrated higher KE
LA-avg
(14.8 [10.6, 20.4] J/m
3
vs. 33.4 [23.9, 61.3] J/m
3
, P < 0.001) and KE
LA-peak
(22.1 [15.9, 28.7] J/m
3
vs. 57.2 [44.5, 121.4] J/m
3
, P < 0.001) than non-obstructive HCM. MR severity was significantly correlated with KE
LA-avg
(rho = 0.81, P < 0.001) and KE
LA-peak
(rho = 0.79, P < 0.001). LVOT ∆P
MRI
was strongly correlated with KE
LA
metrics in obstructive HCM (KE
LA-avg
: rho = 0.86, P < 0.001; KE
LA-peak
: rho = 0.85, P < 0.001).In HCM patients, left atrial kinetic energy, by 4D flow MRI, is associated with MR severity and the degree of LVOT obstruction.]]></abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>33523363</pmid><doi>10.1007/s10554-021-02167-6</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5051-5668</orcidid></addata></record> |
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| identifier | ISSN: 1569-5794 |
| ispartof | The International Journal of Cardiovascular Imaging, 2021-09, Vol.37 (9), p.2755-2765 |
| issn | 1569-5794 1573-0743 1875-8312 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Cardiac Imaging Cardiology Cardiomyopathy Energy Females Heart Imaging Kinetic energy Magnetic resonance imaging Medicine Medicine & Public Health Original Paper Outflow Radiology Regurgitation Systole Ventricle |
| title | 4D flow MRI left atrial kinetic energy in hypertrophic cardiomyopathy is associated with mitral regurgitation and left ventricular outflow tract obstruction |
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