Enhanced Detection of Genitourinary Cancers Using Fragmentation and Copy Number Profiles Obtained from Urinary Cell-Free DNA

Abstract Background Recent studies have reported that examining the fragmentation profiles (FP) of plasma cell-free DNA (cfDNA) further improves the clinical sensitivity of tumor detection. We hypothesized that considering the differences of the FP of urinary cfDNA would increase the clinical sensit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2021-02, Vol.67 (2), p.394-403
Hauptverfasser:	Han, Yang, Li, Xinxin, Zhang, Mingxin, Yang, Yang, Ge, Guangzhe, Wang, Kunxiang, Gong, Yanqing, Liang, Yuan, Niu, Haitao, Ci, Weimin
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Algorithms Analysis Cancer Classification Classifiers Copy number Copy number variations Datasets Deoxyribonucleic acid Diagnosis DNA Fragmentation Fragments Gene sequencing Genomes Genomics Integration Patients Sensitivity Tumors Whole genome sequencing
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!