SHCBP1 interacting with EOGT enhances O-GlcNAcylation of NOTCH1 and promotes the development of pancreatic cancer

O-GlcNAcylation is important in the development and progression of pancreatic ductal adenocarcinoma (PDAC). The glycosyltransferase EGF domain-specific O-linked GlcNAc transferase (EOGT) acts as a key participant in glycosylating NOTCH1. High-throughput sequencing of specimens from 30 advanced PDAC...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 2021-03, Vol.113 (2), p.827-842
Hauptverfasser:	Yang, Can, Hu, Jian-Fei, Zhan, Qian, Wang, Zu-Wei, Li, Ge, Pan, Jing-Jing, Huang, Long, Liao, Cheng-Yu, Huang, Yi, Tian, Yi-Feng, Shen, Bai-Yong, Chen, Jiang-Zhi, Wang, Yao-Dong, Chen, Shi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetylglucosamine - metabolism adenocarcinoma Animals cadherins Cell Line, Tumor cell proliferation EOGT Female genomics HEK293 Cells Humans lungs Male metastasis Mice Mice, Inbred BALB C Mice, Nude Middle Aged N-Acetylglucosaminyltransferases - genetics N-Acetylglucosaminyltransferases - metabolism neoplasm cells Neoplasm Metastasis NOTCH1 O-GlcNAcylation Pancreatic cancer pancreatic neoplasms Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology prognosis Protein Binding protein synthesis Receptor, Notch1 - metabolism Shc Signaling Adaptor Proteins - genetics Shc Signaling Adaptor Proteins - metabolism SHCBP1 xenotransplantation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!