Randall’s plaque and calcium oxalate stone formation: role for immunity and inflammation

Idiopathic calcium oxalate (CaOx) stones often develop attached to Randall’s plaque present on kidney papillary surfaces. Similar to the plaques formed during vascular calcification, Randall’s plaques consist of calcium phosphate crystals mixed with an organic matrix that is rich in proteins, such a...

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Veröffentlicht in:	Nature reviews. Nephrology 2021-06, Vol.17 (6), p.417-433
Hauptverfasser:	Khan, Saeed R., Canales, Benjamin K., Dominguez-Gutierrez, Paul R.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/256 631/443/1338/2193 692/308/1426 692/4022/1585/273 Animals Calcification Calcium Oxalate - metabolism Calcium phosphates Calcium Phosphates - metabolism Care and treatment Collagen Development and progression Humans Hypotheses Immune response Immunity - immunology Immunity - physiology Inflammation Inflammation - immunology Inflammation - metabolism Inflammation - pathology Kidney Calculi - etiology Kidney Calculi - immunology Kidney Calculi - metabolism Kidney Calculi - pathology Kidney Medulla - immunology Kidney Medulla - metabolism Kidney Medulla - pathology Kidney stones Kidneys Medical research Medicine Medicine & Public Health Medicine, Experimental Mineralization Nephrology Observations Pathophysiology Proteins Reactive oxygen species Review Article Urine
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