Decrease of Preoperative Serum Albumin-to-Globulin Ratio as a Prognostic Indicator after Radical Cystectomy in Patients with Urothelial Bladder Cancer
This study aims to evaluate whether preoperative serum albumin-to-globulin ratio (AGR) could predict the prognosis of patients with urothelial bladder cancer (UBC) after radical cystectomy (RC). A total of 176 patients with UBC who underwent RC in a tertiary hospital between 2008 and 2019 were retro...
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| Veröffentlicht in: | Urology journal 2021-01, Vol.18 (1), p.66-73 |
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| container_title | Urology journal |
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| creator | Oh, Jeong Seock Park, Dong Jin Byeon, Kyeong-Hyeon Ha, Yun-Sok Kim, Tae-Hwan Yoo, Eun Sang Kwon, Tae Gyun Kim, Hyun Tae |
| description | This study aims to evaluate whether preoperative serum albumin-to-globulin ratio (AGR) could predict the prognosis of patients with urothelial bladder cancer (UBC) after radical cystectomy (RC).
A total of 176 patients with UBC who underwent RC in a tertiary hospital between 2008 and 2019 were retrospectively analyzed. The AGR was calculated as albumin/(total protein - albumin). In addition, the AGR was divided into two groups for the time-dependent receiver operating characteristic curve (ROC) analysis. Survival was estimated using the Kaplan-Meier analysis and compared using the log-rank test. Cox proportional- hazards models were used for multivariate survival analysis.
The best cutoff AGR value for metastasis prediction was 1.32 based on the ROC curve analysis. Patients who had lower pretreatment AGR ( |
| doi_str_mv | 10.22037/uj.v16i7.6350 |
| format | Article |
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A total of 176 patients with UBC who underwent RC in a tertiary hospital between 2008 and 2019 were retrospectively analyzed. The AGR was calculated as albumin/(total protein - albumin). In addition, the AGR was divided into two groups for the time-dependent receiver operating characteristic curve (ROC) analysis. Survival was estimated using the Kaplan-Meier analysis and compared using the log-rank test. Cox proportional- hazards models were used for multivariate survival analysis.
The best cutoff AGR value for metastasis prediction was 1.32 based on the ROC curve analysis. Patients who had lower pretreatment AGR (<1.32) values composed the low-AGR group (n = 57; 32.4%). On the other hand, the remaining patients (n = 119; 67.6%) composed the high-AGR group. The patients in the low-AGR group had more advanced stage tumors compared with the patients in the high-AGR group. The Kaplan-Meier curves revealed that the patients in the low-AGR group had significantly lower rates of metastasis-free survival (MFS) and cancer-specific survival (CSS). The multivariate Cox regression analysis showed that preoperative AGR was an independent prognostic factor for MFS and CSS.
In this single-institution retrospective study, lower preoperative AGR values demonstrated a poor prognostic effect on MFS and CSS in patients with UBC who underwent RC.</description><identifier>ISSN: 1735-1308</identifier><identifier>EISSN: 1735-546X</identifier><identifier>DOI: 10.22037/uj.v16i7.6350</identifier><identifier>PMID: 33515214</identifier><language>eng</language><publisher>Iran: Urology and Nephrology Research Center</publisher><subject>Bladder cancer ; Medical prognosis ; Metastasis ; Survival analysis</subject><ispartof>Urology journal, 2021-01, Vol.18 (1), p.66-73</ispartof><rights>Copyright Urology and Nephrology Research Center Jan-Feb 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33515214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oh, Jeong Seock</creatorcontrib><creatorcontrib>Park, Dong Jin</creatorcontrib><creatorcontrib>Byeon, Kyeong-Hyeon</creatorcontrib><creatorcontrib>Ha, Yun-Sok</creatorcontrib><creatorcontrib>Kim, Tae-Hwan</creatorcontrib><creatorcontrib>Yoo, Eun Sang</creatorcontrib><creatorcontrib>Kwon, Tae Gyun</creatorcontrib><creatorcontrib>Kim, Hyun Tae</creatorcontrib><title>Decrease of Preoperative Serum Albumin-to-Globulin Ratio as a Prognostic Indicator after Radical Cystectomy in Patients with Urothelial Bladder Cancer</title><title>Urology journal</title><addtitle>Urol J</addtitle><description>This study aims to evaluate whether preoperative serum albumin-to-globulin ratio (AGR) could predict the prognosis of patients with urothelial bladder cancer (UBC) after radical cystectomy (RC).
A total of 176 patients with UBC who underwent RC in a tertiary hospital between 2008 and 2019 were retrospectively analyzed. The AGR was calculated as albumin/(total protein - albumin). In addition, the AGR was divided into two groups for the time-dependent receiver operating characteristic curve (ROC) analysis. Survival was estimated using the Kaplan-Meier analysis and compared using the log-rank test. Cox proportional- hazards models were used for multivariate survival analysis.
The best cutoff AGR value for metastasis prediction was 1.32 based on the ROC curve analysis. Patients who had lower pretreatment AGR (<1.32) values composed the low-AGR group (n = 57; 32.4%). On the other hand, the remaining patients (n = 119; 67.6%) composed the high-AGR group. The patients in the low-AGR group had more advanced stage tumors compared with the patients in the high-AGR group. The Kaplan-Meier curves revealed that the patients in the low-AGR group had significantly lower rates of metastasis-free survival (MFS) and cancer-specific survival (CSS). The multivariate Cox regression analysis showed that preoperative AGR was an independent prognostic factor for MFS and CSS.
In this single-institution retrospective study, lower preoperative AGR values demonstrated a poor prognostic effect on MFS and CSS in patients with UBC who underwent RC.</description><subject>Bladder cancer</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Survival analysis</subject><issn>1735-1308</issn><issn>1735-546X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkE1P3DAQhq0KVD7aa4_IEpdessR27CRHurRbJCRWUKTeook9Aa-ceGs7oP0j_b246nLhNPNKzzMavYR8YeWC81LUF_Nm8cyUrRdKyPIDOWa1kIWs1O-D_c5E2RyRkxg3ZSlzUB_JkRCSSc6qY_L3CnVAiEj9QNcB_RYDJPuM9B7DPNJL18-jnYrki5Xz_ezsRO8y4ClECtnwj5OPyWp6PRmrIflAYUgYMvUvO7rcxYQ6-XFHs7vOLk4p0hebnuhD8OkJnc3YNwfGZG0Jk8bwiRwO4CJ-3s9T8vDj-6_lz-LmdnW9vLwptly0qWBGtqZvsAWpBDKQre6N0RpqVed2NAxCY22UAt1WbOhbxWveCCEGGKBkWpySr__vboP_M2NM3WijRudgQj_HjleNaFglap7R83foxs9hyt91vGGtLBvVqkyd7am5H9F022BHCLvurXHxCpCuhXY</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Oh, Jeong Seock</creator><creator>Park, Dong Jin</creator><creator>Byeon, Kyeong-Hyeon</creator><creator>Ha, Yun-Sok</creator><creator>Kim, Tae-Hwan</creator><creator>Yoo, Eun Sang</creator><creator>Kwon, Tae Gyun</creator><creator>Kim, Hyun Tae</creator><general>Urology and Nephrology Research Center</general><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20210101</creationdate><title>Decrease of Preoperative Serum Albumin-to-Globulin Ratio as a Prognostic Indicator after Radical Cystectomy in Patients with Urothelial Bladder Cancer</title><author>Oh, Jeong Seock ; Park, Dong Jin ; Byeon, Kyeong-Hyeon ; Ha, Yun-Sok ; Kim, Tae-Hwan ; Yoo, Eun Sang ; Kwon, Tae Gyun ; Kim, Hyun Tae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-1d59db8e9a563e1a59cbddcca767203caf3ce7d66ac941fb962728333fafa01c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bladder cancer</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Survival analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, Jeong Seock</creatorcontrib><creatorcontrib>Park, Dong Jin</creatorcontrib><creatorcontrib>Byeon, Kyeong-Hyeon</creatorcontrib><creatorcontrib>Ha, Yun-Sok</creatorcontrib><creatorcontrib>Kim, Tae-Hwan</creatorcontrib><creatorcontrib>Yoo, Eun Sang</creatorcontrib><creatorcontrib>Kwon, Tae Gyun</creatorcontrib><creatorcontrib>Kim, Hyun Tae</creatorcontrib><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Urology journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh, Jeong Seock</au><au>Park, Dong Jin</au><au>Byeon, Kyeong-Hyeon</au><au>Ha, Yun-Sok</au><au>Kim, Tae-Hwan</au><au>Yoo, Eun Sang</au><au>Kwon, Tae Gyun</au><au>Kim, Hyun Tae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decrease of Preoperative Serum Albumin-to-Globulin Ratio as a Prognostic Indicator after Radical Cystectomy in Patients with Urothelial Bladder Cancer</atitle><jtitle>Urology journal</jtitle><addtitle>Urol J</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>18</volume><issue>1</issue><spage>66</spage><epage>73</epage><pages>66-73</pages><issn>1735-1308</issn><eissn>1735-546X</eissn><abstract>This study aims to evaluate whether preoperative serum albumin-to-globulin ratio (AGR) could predict the prognosis of patients with urothelial bladder cancer (UBC) after radical cystectomy (RC).
A total of 176 patients with UBC who underwent RC in a tertiary hospital between 2008 and 2019 were retrospectively analyzed. The AGR was calculated as albumin/(total protein - albumin). In addition, the AGR was divided into two groups for the time-dependent receiver operating characteristic curve (ROC) analysis. Survival was estimated using the Kaplan-Meier analysis and compared using the log-rank test. Cox proportional- hazards models were used for multivariate survival analysis.
The best cutoff AGR value for metastasis prediction was 1.32 based on the ROC curve analysis. Patients who had lower pretreatment AGR (<1.32) values composed the low-AGR group (n = 57; 32.4%). On the other hand, the remaining patients (n = 119; 67.6%) composed the high-AGR group. The patients in the low-AGR group had more advanced stage tumors compared with the patients in the high-AGR group. The Kaplan-Meier curves revealed that the patients in the low-AGR group had significantly lower rates of metastasis-free survival (MFS) and cancer-specific survival (CSS). The multivariate Cox regression analysis showed that preoperative AGR was an independent prognostic factor for MFS and CSS.
In this single-institution retrospective study, lower preoperative AGR values demonstrated a poor prognostic effect on MFS and CSS in patients with UBC who underwent RC.</abstract><cop>Iran</cop><pub>Urology and Nephrology Research Center</pub><pmid>33515214</pmid><doi>10.22037/uj.v16i7.6350</doi><tpages>8</tpages></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Bladder cancer Medical prognosis Metastasis Survival analysis |
| title | Decrease of Preoperative Serum Albumin-to-Globulin Ratio as a Prognostic Indicator after Radical Cystectomy in Patients with Urothelial Bladder Cancer |
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