Protein Binder (ProBi) as a New Class of Structurally Robust Non-Antibody Protein Scaffold for Directed Evolution

Engineered small non-antibody protein scaffolds are a promising alternative to antibodies and are especially attractive for use in protein therapeutics and diagnostics. The advantages include smaller size and a more robust, single-domain structural framework with a defined binding surface amenable t...

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Veröffentlicht in:	Viruses 2021-01, Vol.13 (2), p.190
Hauptverfasser:	Pham, Phuong Ngoc, Huličiak, Maroš, Biedermannová, Lada, Černý, Jiří, Charnavets, Tatsiana, Fuertes, Gustavo, Herynek, Štěpán, Kolářová, Lucie, Kolenko, Petr, Pavlíček, Jiří, Zahradník, Jiří, Mikulecky, Pavel, Schneider, Bohdan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Amino Acid Sequence Amino acids Antibodies Candidates Clinical trials Cloning computational saturation Computer applications Computer Simulation Cytokines Databases, Protein Deoxyribonucleic acid Directed evolution Directed Molecular Evolution - methods DNA E coli Enzymes Evolution Interleukin 10 Interleukin-10 - metabolism Mutagenesis Mutation Protein Binding Protein Conformation Protein Engineering Protein folding protein scaffold Protein Stability Proteins Proteins - chemistry Proteins - genetics Proteins - metabolism Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism ribosome display Ribosomes - metabolism Thermal stability
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