Refining prediction of survival after TIPS with the novel Freiburg index of post-TIPS survival
Transjugular intrahepatic portosystemic shunt (TIPS) implantation is an effective and safe treatment for complications of portal hypertension. Survival prediction is important in these patients as they constitute a high-risk population. Therefore, the aim of our study was to develop an alternative p...
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| Veröffentlicht in: | Journal of hepatology 2021-06, Vol.74 (6), p.1362-1372 |
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| creator | Bettinger, Dominik Sturm, Lukas Pfaff, Lena Hahn, Felix Kloeckner, Roman Volkwein, Lara Praktiknjo, Michael Lv, Yong Han, Guohong Huber, Jan Patrick Boettler, Tobias Reincke, Marlene Klinger, Christoph Caca, Karel Heinzow, Hauke Seifert, Leon Louis Weiss, Karl Heinz Rupp, Christian Piecha, Felix Kluwe, Johannes Zipprich, Alexander Luxenburger, Hendrik Neumann-Haefelin, Christoph Schmidt, Arthur Jansen, Christian Meyer, Carsten Uschner, Frank E. Brol, Maximilian J. Trebicka, Jonel Rössle, Martin Thimme, Robert Schultheiss, Michael |
| description | Transjugular intrahepatic portosystemic shunt (TIPS) implantation is an effective and safe treatment for complications of portal hypertension. Survival prediction is important in these patients as they constitute a high-risk population. Therefore, the aim of our study was to develop an alternative prognostic model for accurate survival prediction after planned TIPS implantation.
A total of 1,871 patients with de novo TIPS implantation for ascites or secondary prophylaxis of variceal bleeding were recruited retrospectively. The study cohort was divided into a training set (80% of study patients; n = 1,496) and a validation set (20% of study patients; n = 375). Further, patients with early (preemptive) TIPS implantation due to variceal bleeding were included as another validation cohort (n = 290). Medical data and overall survival (OS) were assessed. A Cox regression model was used to create an alternative prediction model, which includes significant prognostic factors.
Age, bilirubin, albumin and creatinine were the most important prognostic factors. These parameters were included in a new score named the Freiburg index of post-TIPS survival (FIPS). The FIPS score was able to identify high-risk patients with a significantly reduced median survival of 5.0 (3.1–6.9) months after TIPS implantation in the training set. These results were confirmed in the validation set (median survival of 3.1 [0.9–5.3] months). The FIPS score showed better prognostic discrimination compared to the Child-Pugh, MELD, MELD-Na score and the bilirubin-platelet model. However, the FIPS score showed insufficient prognostic discrimination in patients with early TIPS implantation.
The FIPS score is superior to established scoring systems for the identification of high-risk patients with a worse prognosis following elective TIPS implantation.
Implantation of a transjugular intrahepatic portosystemic shunt (TIPS) is a safe and effective treatment for patients with cirrhosis and clinically significant portal hypertension. However, risk stratification is a major challenge in these patients as currently available scoring systems have major drawbacks. Age, bilirubin, albumin and creatinine were included in a new risk score which was named the Freiburg index of post-TIPS survival (FIPS). The FIPS score can identify patients at high risk and may guide clinical decision making.
[Display omitted]
•Risk stratification is a major challenge in patients undergoing TIPS implantation.•Age, bilirubin, a |
| doi_str_mv | 10.1016/j.jhep.2021.01.023 |
| format | Article |
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A total of 1,871 patients with de novo TIPS implantation for ascites or secondary prophylaxis of variceal bleeding were recruited retrospectively. The study cohort was divided into a training set (80% of study patients; n = 1,496) and a validation set (20% of study patients; n = 375). Further, patients with early (preemptive) TIPS implantation due to variceal bleeding were included as another validation cohort (n = 290). Medical data and overall survival (OS) were assessed. A Cox regression model was used to create an alternative prediction model, which includes significant prognostic factors.
Age, bilirubin, albumin and creatinine were the most important prognostic factors. These parameters were included in a new score named the Freiburg index of post-TIPS survival (FIPS). The FIPS score was able to identify high-risk patients with a significantly reduced median survival of 5.0 (3.1–6.9) months after TIPS implantation in the training set. These results were confirmed in the validation set (median survival of 3.1 [0.9–5.3] months). The FIPS score showed better prognostic discrimination compared to the Child-Pugh, MELD, MELD-Na score and the bilirubin-platelet model. However, the FIPS score showed insufficient prognostic discrimination in patients with early TIPS implantation.
The FIPS score is superior to established scoring systems for the identification of high-risk patients with a worse prognosis following elective TIPS implantation.
Implantation of a transjugular intrahepatic portosystemic shunt (TIPS) is a safe and effective treatment for patients with cirrhosis and clinically significant portal hypertension. However, risk stratification is a major challenge in these patients as currently available scoring systems have major drawbacks. Age, bilirubin, albumin and creatinine were included in a new risk score which was named the Freiburg index of post-TIPS survival (FIPS). The FIPS score can identify patients at high risk and may guide clinical decision making.
[Display omitted]
•Risk stratification is a major challenge in patients undergoing TIPS implantation.•Age, bilirubin, albumin and creatinine emerged as the most significant predictors of 6-months survival after TIPS implantation.•These measures were summarized in a new score named the Freiburg index of post-TIPS survival (FIPS).•The FIPS score clearly identifies a high-risk group of patients with a markedly reduced survival after TIPS implantation.•Importantly, prognostic discrimination was superior to the MELD, MELD-Na, Child-Pugh score and the bilirubin-platelet model.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/j.jhep.2021.01.023</identifier><identifier>PMID: 33508376</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Age Factors ; Aged ; Albumin ; Ascites ; Ascites - surgery ; Bilirubin ; Bilirubin - blood ; Bleeding ; Child-Pugh score ; Cirrhosis ; Clinical Decision-Making - methods ; Creatinine ; Creatinine - blood ; Decision making ; Esophageal and Gastric Varices - surgery ; Female ; Gastrointestinal Hemorrhage - surgery ; Humans ; Hypertension ; Liver cirrhosis ; Liver Cirrhosis - surgery ; Male ; Medical prognosis ; MELD score ; Middle Aged ; Patients ; Portasystemic Shunt, Transjugular Intrahepatic - adverse effects ; Portasystemic Shunt, Transjugular Intrahepatic - mortality ; Prediction models ; Prognosis ; Prophylaxis ; Research Design ; Retrospective Studies ; Risk Factors ; Risk groups ; risk stratification ; Secondary Prevention - methods ; Serum Albumin, Human - analysis ; Survival ; Survival Rate ; transjugular intrahepatic portosystemic shunt ; Treatment Outcome</subject><ispartof>Journal of hepatology, 2021-06, Vol.74 (6), p.1362-1372</ispartof><rights>2021 European Association for the Study of the Liver</rights><rights>Copyright © 2021 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Jun 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-bb342b0df19ca05b6c1208877bf0b159870769b0c58793f8ce7fddcf39e9a4843</citedby><cites>FETCH-LOGICAL-c384t-bb342b0df19ca05b6c1208877bf0b159870769b0c58793f8ce7fddcf39e9a4843</cites><orcidid>0000-0001-5492-4792 ; 0000-0002-8782-8729 ; 0000-0003-2879-7560 ; 0000-0001-5122-9014 ; 0000-0003-4568-3776 ; 0000-0002-3623-7857 ; 0000-0002-1195-055X ; 0000-0001-7182-8620 ; 0000-0002-7244-006X ; 0000-0002-7028-3881 ; 0000-0001-8546-8064 ; 0000-0001-7033-9956 ; 0000-0001-7351-1387 ; 0000-0001-8403-7983</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jhep.2021.01.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33508376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bettinger, Dominik</creatorcontrib><creatorcontrib>Sturm, Lukas</creatorcontrib><creatorcontrib>Pfaff, Lena</creatorcontrib><creatorcontrib>Hahn, Felix</creatorcontrib><creatorcontrib>Kloeckner, Roman</creatorcontrib><creatorcontrib>Volkwein, Lara</creatorcontrib><creatorcontrib>Praktiknjo, Michael</creatorcontrib><creatorcontrib>Lv, Yong</creatorcontrib><creatorcontrib>Han, Guohong</creatorcontrib><creatorcontrib>Huber, Jan Patrick</creatorcontrib><creatorcontrib>Boettler, Tobias</creatorcontrib><creatorcontrib>Reincke, Marlene</creatorcontrib><creatorcontrib>Klinger, Christoph</creatorcontrib><creatorcontrib>Caca, Karel</creatorcontrib><creatorcontrib>Heinzow, Hauke</creatorcontrib><creatorcontrib>Seifert, Leon Louis</creatorcontrib><creatorcontrib>Weiss, Karl Heinz</creatorcontrib><creatorcontrib>Rupp, Christian</creatorcontrib><creatorcontrib>Piecha, Felix</creatorcontrib><creatorcontrib>Kluwe, Johannes</creatorcontrib><creatorcontrib>Zipprich, Alexander</creatorcontrib><creatorcontrib>Luxenburger, Hendrik</creatorcontrib><creatorcontrib>Neumann-Haefelin, Christoph</creatorcontrib><creatorcontrib>Schmidt, Arthur</creatorcontrib><creatorcontrib>Jansen, Christian</creatorcontrib><creatorcontrib>Meyer, Carsten</creatorcontrib><creatorcontrib>Uschner, Frank E.</creatorcontrib><creatorcontrib>Brol, Maximilian J.</creatorcontrib><creatorcontrib>Trebicka, Jonel</creatorcontrib><creatorcontrib>Rössle, Martin</creatorcontrib><creatorcontrib>Thimme, Robert</creatorcontrib><creatorcontrib>Schultheiss, Michael</creatorcontrib><title>Refining prediction of survival after TIPS with the novel Freiburg index of post-TIPS survival</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>Transjugular intrahepatic portosystemic shunt (TIPS) implantation is an effective and safe treatment for complications of portal hypertension. Survival prediction is important in these patients as they constitute a high-risk population. Therefore, the aim of our study was to develop an alternative prognostic model for accurate survival prediction after planned TIPS implantation.
A total of 1,871 patients with de novo TIPS implantation for ascites or secondary prophylaxis of variceal bleeding were recruited retrospectively. The study cohort was divided into a training set (80% of study patients; n = 1,496) and a validation set (20% of study patients; n = 375). Further, patients with early (preemptive) TIPS implantation due to variceal bleeding were included as another validation cohort (n = 290). Medical data and overall survival (OS) were assessed. A Cox regression model was used to create an alternative prediction model, which includes significant prognostic factors.
Age, bilirubin, albumin and creatinine were the most important prognostic factors. These parameters were included in a new score named the Freiburg index of post-TIPS survival (FIPS). The FIPS score was able to identify high-risk patients with a significantly reduced median survival of 5.0 (3.1–6.9) months after TIPS implantation in the training set. These results were confirmed in the validation set (median survival of 3.1 [0.9–5.3] months). The FIPS score showed better prognostic discrimination compared to the Child-Pugh, MELD, MELD-Na score and the bilirubin-platelet model. However, the FIPS score showed insufficient prognostic discrimination in patients with early TIPS implantation.
The FIPS score is superior to established scoring systems for the identification of high-risk patients with a worse prognosis following elective TIPS implantation.
Implantation of a transjugular intrahepatic portosystemic shunt (TIPS) is a safe and effective treatment for patients with cirrhosis and clinically significant portal hypertension. However, risk stratification is a major challenge in these patients as currently available scoring systems have major drawbacks. Age, bilirubin, albumin and creatinine were included in a new risk score which was named the Freiburg index of post-TIPS survival (FIPS). The FIPS score can identify patients at high risk and may guide clinical decision making.
[Display omitted]
•Risk stratification is a major challenge in patients undergoing TIPS implantation.•Age, bilirubin, albumin and creatinine emerged as the most significant predictors of 6-months survival after TIPS implantation.•These measures were summarized in a new score named the Freiburg index of post-TIPS survival (FIPS).•The FIPS score clearly identifies a high-risk group of patients with a markedly reduced survival after TIPS implantation.•Importantly, prognostic discrimination was superior to the MELD, MELD-Na, Child-Pugh score and the bilirubin-platelet model.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Albumin</subject><subject>Ascites</subject><subject>Ascites - surgery</subject><subject>Bilirubin</subject><subject>Bilirubin - blood</subject><subject>Bleeding</subject><subject>Child-Pugh score</subject><subject>Cirrhosis</subject><subject>Clinical Decision-Making - methods</subject><subject>Creatinine</subject><subject>Creatinine - blood</subject><subject>Decision making</subject><subject>Esophageal and Gastric Varices - surgery</subject><subject>Female</subject><subject>Gastrointestinal Hemorrhage - surgery</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - surgery</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>MELD score</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Portasystemic Shunt, Transjugular Intrahepatic - adverse effects</subject><subject>Portasystemic Shunt, Transjugular Intrahepatic - mortality</subject><subject>Prediction models</subject><subject>Prognosis</subject><subject>Prophylaxis</subject><subject>Research Design</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Risk groups</subject><subject>risk stratification</subject><subject>Secondary Prevention - methods</subject><subject>Serum Albumin, Human - analysis</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>transjugular intrahepatic portosystemic shunt</subject><subject>Treatment Outcome</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAURS0EokPLD7CoLHXDJsOzncSO1E1VUahUCUTLFit2njuOMnFqJwP8PR6m7YIF0pXe5tyrp0PIOwZrBqz-0K_7DU5rDpytIYeLF2TFaoAC6pK9JKsMqUJxqY7Im5R6ABDQlK_JkRAVKCHrFfnxDZ0f_XhPp4idt7MPIw2OpiXu_K4daOtmjPTu-ust_ennDZ03SMeww4FeRfRmiffUjx3-2pemkObiL_pUPyGvXDskfPt4j8n3q493l5-Lmy-fri8vbgorVDkXxoiSG-gca2wLlakt46CUlMaBYVWjJMi6MWArJRvhlEXpus460WDTlqoUx-T9YXeK4WHBNOutTxaHoR0xLEnzUgnFuORVRs_-QfuwxDF_p3lVNZIJqHim-IGyMaQU0ekp-m0bf2sGem9f93pvX-_ta8jhIpdOH6cXs8XuufKkOwPnBwCzi53HqJP1ONpsPqKddRf8__b_AJU5lPg</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Bettinger, Dominik</creator><creator>Sturm, 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prediction of survival after TIPS with the novel Freiburg index of post-TIPS survival</title><author>Bettinger, Dominik ; Sturm, Lukas ; Pfaff, Lena ; Hahn, Felix ; Kloeckner, Roman ; Volkwein, Lara ; Praktiknjo, Michael ; Lv, Yong ; Han, Guohong ; Huber, Jan Patrick ; Boettler, Tobias ; Reincke, Marlene ; Klinger, Christoph ; Caca, Karel ; Heinzow, Hauke ; Seifert, Leon Louis ; Weiss, Karl Heinz ; Rupp, Christian ; Piecha, Felix ; Kluwe, Johannes ; Zipprich, Alexander ; Luxenburger, Hendrik ; Neumann-Haefelin, Christoph ; Schmidt, Arthur ; Jansen, Christian ; Meyer, Carsten ; Uschner, Frank E. ; Brol, Maximilian J. ; Trebicka, Jonel ; Rössle, Martin ; Thimme, Robert ; Schultheiss, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-bb342b0df19ca05b6c1208877bf0b159870769b0c58793f8ce7fddcf39e9a4843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age 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Patrick</creatorcontrib><creatorcontrib>Boettler, Tobias</creatorcontrib><creatorcontrib>Reincke, Marlene</creatorcontrib><creatorcontrib>Klinger, Christoph</creatorcontrib><creatorcontrib>Caca, Karel</creatorcontrib><creatorcontrib>Heinzow, Hauke</creatorcontrib><creatorcontrib>Seifert, Leon Louis</creatorcontrib><creatorcontrib>Weiss, Karl Heinz</creatorcontrib><creatorcontrib>Rupp, Christian</creatorcontrib><creatorcontrib>Piecha, Felix</creatorcontrib><creatorcontrib>Kluwe, Johannes</creatorcontrib><creatorcontrib>Zipprich, Alexander</creatorcontrib><creatorcontrib>Luxenburger, Hendrik</creatorcontrib><creatorcontrib>Neumann-Haefelin, Christoph</creatorcontrib><creatorcontrib>Schmidt, Arthur</creatorcontrib><creatorcontrib>Jansen, Christian</creatorcontrib><creatorcontrib>Meyer, Carsten</creatorcontrib><creatorcontrib>Uschner, Frank E.</creatorcontrib><creatorcontrib>Brol, Maximilian J.</creatorcontrib><creatorcontrib>Trebicka, Jonel</creatorcontrib><creatorcontrib>Rössle, Martin</creatorcontrib><creatorcontrib>Thimme, Robert</creatorcontrib><creatorcontrib>Schultheiss, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bettinger, Dominik</au><au>Sturm, Lukas</au><au>Pfaff, Lena</au><au>Hahn, Felix</au><au>Kloeckner, Roman</au><au>Volkwein, Lara</au><au>Praktiknjo, Michael</au><au>Lv, Yong</au><au>Han, Guohong</au><au>Huber, Jan Patrick</au><au>Boettler, Tobias</au><au>Reincke, Marlene</au><au>Klinger, Christoph</au><au>Caca, Karel</au><au>Heinzow, Hauke</au><au>Seifert, Leon Louis</au><au>Weiss, Karl Heinz</au><au>Rupp, Christian</au><au>Piecha, Felix</au><au>Kluwe, Johannes</au><au>Zipprich, Alexander</au><au>Luxenburger, Hendrik</au><au>Neumann-Haefelin, Christoph</au><au>Schmidt, Arthur</au><au>Jansen, Christian</au><au>Meyer, Carsten</au><au>Uschner, Frank E.</au><au>Brol, Maximilian J.</au><au>Trebicka, Jonel</au><au>Rössle, Martin</au><au>Thimme, Robert</au><au>Schultheiss, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Refining prediction of survival after TIPS with the novel Freiburg index of post-TIPS survival</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>2021-06</date><risdate>2021</risdate><volume>74</volume><issue>6</issue><spage>1362</spage><epage>1372</epage><pages>1362-1372</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><abstract>Transjugular intrahepatic portosystemic shunt (TIPS) implantation is an effective and safe treatment for complications of portal hypertension. Survival prediction is important in these patients as they constitute a high-risk population. Therefore, the aim of our study was to develop an alternative prognostic model for accurate survival prediction after planned TIPS implantation.
A total of 1,871 patients with de novo TIPS implantation for ascites or secondary prophylaxis of variceal bleeding were recruited retrospectively. The study cohort was divided into a training set (80% of study patients; n = 1,496) and a validation set (20% of study patients; n = 375). Further, patients with early (preemptive) TIPS implantation due to variceal bleeding were included as another validation cohort (n = 290). Medical data and overall survival (OS) were assessed. A Cox regression model was used to create an alternative prediction model, which includes significant prognostic factors.
Age, bilirubin, albumin and creatinine were the most important prognostic factors. These parameters were included in a new score named the Freiburg index of post-TIPS survival (FIPS). The FIPS score was able to identify high-risk patients with a significantly reduced median survival of 5.0 (3.1–6.9) months after TIPS implantation in the training set. These results were confirmed in the validation set (median survival of 3.1 [0.9–5.3] months). The FIPS score showed better prognostic discrimination compared to the Child-Pugh, MELD, MELD-Na score and the bilirubin-platelet model. However, the FIPS score showed insufficient prognostic discrimination in patients with early TIPS implantation.
The FIPS score is superior to established scoring systems for the identification of high-risk patients with a worse prognosis following elective TIPS implantation.
Implantation of a transjugular intrahepatic portosystemic shunt (TIPS) is a safe and effective treatment for patients with cirrhosis and clinically significant portal hypertension. However, risk stratification is a major challenge in these patients as currently available scoring systems have major drawbacks. Age, bilirubin, albumin and creatinine were included in a new risk score which was named the Freiburg index of post-TIPS survival (FIPS). The FIPS score can identify patients at high risk and may guide clinical decision making.
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•Risk stratification is a major challenge in patients undergoing TIPS implantation.•Age, bilirubin, albumin and creatinine emerged as the most significant predictors of 6-months survival after TIPS implantation.•These measures were summarized in a new score named the Freiburg index of post-TIPS survival (FIPS).•The FIPS score clearly identifies a high-risk group of patients with a markedly reduced survival after TIPS implantation.•Importantly, prognostic discrimination was superior to the MELD, MELD-Na, Child-Pugh score and the bilirubin-platelet model.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33508376</pmid><doi>10.1016/j.jhep.2021.01.023</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5492-4792</orcidid><orcidid>https://orcid.org/0000-0002-8782-8729</orcidid><orcidid>https://orcid.org/0000-0003-2879-7560</orcidid><orcidid>https://orcid.org/0000-0001-5122-9014</orcidid><orcidid>https://orcid.org/0000-0003-4568-3776</orcidid><orcidid>https://orcid.org/0000-0002-3623-7857</orcidid><orcidid>https://orcid.org/0000-0002-1195-055X</orcidid><orcidid>https://orcid.org/0000-0001-7182-8620</orcidid><orcidid>https://orcid.org/0000-0002-7244-006X</orcidid><orcidid>https://orcid.org/0000-0002-7028-3881</orcidid><orcidid>https://orcid.org/0000-0001-8546-8064</orcidid><orcidid>https://orcid.org/0000-0001-7033-9956</orcidid><orcidid>https://orcid.org/0000-0001-7351-1387</orcidid><orcidid>https://orcid.org/0000-0001-8403-7983</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-8278 |
| ispartof | Journal of hepatology, 2021-06, Vol.74 (6), p.1362-1372 |
| issn | 0168-8278 1600-0641 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2483812725 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Age Factors Aged Albumin Ascites Ascites - surgery Bilirubin Bilirubin - blood Bleeding Child-Pugh score Cirrhosis Clinical Decision-Making - methods Creatinine Creatinine - blood Decision making Esophageal and Gastric Varices - surgery Female Gastrointestinal Hemorrhage - surgery Humans Hypertension Liver cirrhosis Liver Cirrhosis - surgery Male Medical prognosis MELD score Middle Aged Patients Portasystemic Shunt, Transjugular Intrahepatic - adverse effects Portasystemic Shunt, Transjugular Intrahepatic - mortality Prediction models Prognosis Prophylaxis Research Design Retrospective Studies Risk Factors Risk groups risk stratification Secondary Prevention - methods Serum Albumin, Human - analysis Survival Survival Rate transjugular intrahepatic portosystemic shunt Treatment Outcome |
| title | Refining prediction of survival after TIPS with the novel Freiburg index of post-TIPS survival |
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