Oxindole–curcumin hybrid compound enhances the transcription of γ-glutamylcysteine ligase

Glutathione (GSH), which is particularly important for antioxidant defenses, is synthesized in two sequential enzymatic reactions catalyzed by γ-glutamylcysteine ligase (GCL) and GSH synthase. GCL comprises catalytic (GCLC) and regulatory subunits and catalyzes the rate-limiting step in de novo GSH...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 2021-04, Vol.896, p.173898-173898, Article 173898
Hauptverfasser:	Ikawa, Takanori, Sato, Mina, Oh-hashi, Kentaro, Furuta, Kyoji, Hirata, Yoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Glutamate-Cysteine Ligase - genetics Glutamate-Cysteine Ligase - metabolism Glutathione Glutathione - metabolism Hippocampus - drug effects Hippocampus - enzymology Hippocampus - pathology HT22 cells Mice Neurons - drug effects Neurons - enzymology Neurons - pathology Neuroprotective Agents - pharmacology Oxidative Stress Oxindole Oxytosis/ferroptosis PC12 Cells Promoter Regions, Genetic Rats Sp1 Transcription Factor - metabolism Transcription, Genetic - drug effects Transcriptional Activation - drug effects γ-Glutamylcysteine ligase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!