The long-term risk of lymphoma and skin cancer did not increase after topical calcineurin inhibitor use and phototherapy in a cohort of 25,694 patients with vitiligo
Topical calcineurin inhibitors have been used to treat vitiligo, either alone or in combination with phototherapy; however, the long-term safety of these agents remains controversial. To investigate the risk of lymphoma and skin cancer in vitiligo patients who received topical calcineurin inhibitors...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 2021-06, Vol.84 (6), p.1619-1627 |
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| creator | Ju, Hyun Jeong Han, Ju Hee Kim, Min-Soo Lee, Si-Hyung Shin, Jung-Won Choi, Mira Jeong, Ki-Heon Han, Tae Young Choi, Chong Won Lee, Hee Jung Oh, Sang Ho Lee, Sang Hoon Kim, Dong Hyun Shin, Jeonghyun Lee, Jong Hee Kim, Sang Seok Kang, Hee Young Chang, Sung Eun Kim, Jeong-Soo Lee, Dong-Youn Choi, Gwang Seong Suh, Dae Hun Chan Kim, You Park, Chul Jong Kim, Ki-Ho Lee, Ai-Young Chan Park, Kyoung Lee, Mu-Hyoung Bae, Jung Min |
| description | Topical calcineurin inhibitors have been used to treat vitiligo, either alone or in combination with phototherapy; however, the long-term safety of these agents remains controversial.
To investigate the risk of lymphoma and skin cancer in vitiligo patients who received topical calcineurin inhibitors or phototherapy.
A multicenter retrospective cohort study of 25,694 vitiligo patients who received topical calcineurin inhibitors or phototherapy for 6 weeks or more between 2001 and 2019 was performed. Cumulative doses of topical calcineurin inhibitors and total phototherapy sessions were determined. Outcomes were the development of lymphoma or skin cancer after enrollment, confirmed through chart review and pathology reports.
During 95,203 person-years, 13 cases of lymphoma, 22 of actinic keratosis, 15 of nonmelanoma skin cancer, and 5 of melanoma were observed. The risk of lymphoma and skin cancer was not significantly increased by topical calcineurin inhibitor dose or phototherapy sessions. The interaction between the topical calcineurin inhibitors and phototherapy was not associated with an increased risk of skin cancer.
Retrospective study, individual follow-up duration less than 4 years, and no adjustment for comorbidities and medication history. Not generalizable to other races.
The long-term risk of skin cancer or lymphoma was not associated with the use of topical calcineurin inhibitors, phototherapy, and both treatments in combination in patients with vitiligo. |
| doi_str_mv | 10.1016/j.jaad.2021.01.067 |
| format | Article |
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To investigate the risk of lymphoma and skin cancer in vitiligo patients who received topical calcineurin inhibitors or phototherapy.
A multicenter retrospective cohort study of 25,694 vitiligo patients who received topical calcineurin inhibitors or phototherapy for 6 weeks or more between 2001 and 2019 was performed. Cumulative doses of topical calcineurin inhibitors and total phototherapy sessions were determined. Outcomes were the development of lymphoma or skin cancer after enrollment, confirmed through chart review and pathology reports.
During 95,203 person-years, 13 cases of lymphoma, 22 of actinic keratosis, 15 of nonmelanoma skin cancer, and 5 of melanoma were observed. The risk of lymphoma and skin cancer was not significantly increased by topical calcineurin inhibitor dose or phototherapy sessions. The interaction between the topical calcineurin inhibitors and phototherapy was not associated with an increased risk of skin cancer.
Retrospective study, individual follow-up duration less than 4 years, and no adjustment for comorbidities and medication history. Not generalizable to other races.
The long-term risk of skin cancer or lymphoma was not associated with the use of topical calcineurin inhibitors, phototherapy, and both treatments in combination in patients with vitiligo.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/j.jaad.2021.01.067</identifier><identifier>PMID: 33508387</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>actinic keratosis ; excimer laser ; lymphoma ; melanoma ; narrowband ultraviolet B ; skin cancer ; tacrolimus ; vitiligo</subject><ispartof>Journal of the American Academy of Dermatology, 2021-06, Vol.84 (6), p.1619-1627</ispartof><rights>2021 American Academy of Dermatology, Inc.</rights><rights>Copyright © 2021 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-3d97f70d3a1689d11604f36b471343f600a7658b9b5f24bd9b688aa28109590f3</citedby><cites>FETCH-LOGICAL-c356t-3d97f70d3a1689d11604f36b471343f600a7658b9b5f24bd9b688aa28109590f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaad.2021.01.067$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33508387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ju, Hyun Jeong</creatorcontrib><creatorcontrib>Han, Ju Hee</creatorcontrib><creatorcontrib>Kim, Min-Soo</creatorcontrib><creatorcontrib>Lee, Si-Hyung</creatorcontrib><creatorcontrib>Shin, Jung-Won</creatorcontrib><creatorcontrib>Choi, Mira</creatorcontrib><creatorcontrib>Jeong, Ki-Heon</creatorcontrib><creatorcontrib>Han, Tae Young</creatorcontrib><creatorcontrib>Choi, Chong Won</creatorcontrib><creatorcontrib>Lee, Hee Jung</creatorcontrib><creatorcontrib>Oh, Sang Ho</creatorcontrib><creatorcontrib>Lee, Sang Hoon</creatorcontrib><creatorcontrib>Kim, Dong Hyun</creatorcontrib><creatorcontrib>Shin, Jeonghyun</creatorcontrib><creatorcontrib>Lee, Jong Hee</creatorcontrib><creatorcontrib>Kim, Sang Seok</creatorcontrib><creatorcontrib>Kang, Hee Young</creatorcontrib><creatorcontrib>Chang, Sung Eun</creatorcontrib><creatorcontrib>Kim, Jeong-Soo</creatorcontrib><creatorcontrib>Lee, Dong-Youn</creatorcontrib><creatorcontrib>Choi, Gwang Seong</creatorcontrib><creatorcontrib>Suh, Dae Hun</creatorcontrib><creatorcontrib>Chan Kim, You</creatorcontrib><creatorcontrib>Park, Chul Jong</creatorcontrib><creatorcontrib>Kim, Ki-Ho</creatorcontrib><creatorcontrib>Lee, Ai-Young</creatorcontrib><creatorcontrib>Chan Park, Kyoung</creatorcontrib><creatorcontrib>Lee, Mu-Hyoung</creatorcontrib><creatorcontrib>Bae, Jung Min</creatorcontrib><creatorcontrib>Korean Society for Vitiligo and the Korean Society for Photomedicine</creatorcontrib><title>The long-term risk of lymphoma and skin cancer did not increase after topical calcineurin inhibitor use and phototherapy in a cohort of 25,694 patients with vitiligo</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Topical calcineurin inhibitors have been used to treat vitiligo, either alone or in combination with phototherapy; however, the long-term safety of these agents remains controversial.
To investigate the risk of lymphoma and skin cancer in vitiligo patients who received topical calcineurin inhibitors or phototherapy.
A multicenter retrospective cohort study of 25,694 vitiligo patients who received topical calcineurin inhibitors or phototherapy for 6 weeks or more between 2001 and 2019 was performed. Cumulative doses of topical calcineurin inhibitors and total phototherapy sessions were determined. Outcomes were the development of lymphoma or skin cancer after enrollment, confirmed through chart review and pathology reports.
During 95,203 person-years, 13 cases of lymphoma, 22 of actinic keratosis, 15 of nonmelanoma skin cancer, and 5 of melanoma were observed. The risk of lymphoma and skin cancer was not significantly increased by topical calcineurin inhibitor dose or phototherapy sessions. The interaction between the topical calcineurin inhibitors and phototherapy was not associated with an increased risk of skin cancer.
Retrospective study, individual follow-up duration less than 4 years, and no adjustment for comorbidities and medication history. Not generalizable to other races.
The long-term risk of skin cancer or lymphoma was not associated with the use of topical calcineurin inhibitors, phototherapy, and both treatments in combination in patients with vitiligo.</description><subject>actinic keratosis</subject><subject>excimer laser</subject><subject>lymphoma</subject><subject>melanoma</subject><subject>narrowband ultraviolet B</subject><subject>skin cancer</subject><subject>tacrolimus</subject><subject>vitiligo</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAUhS0EotPCC7BAXrIgg38SO5bYoAoKUiU2ZW05ttPcaWIH2ymaB-I98WgKS6QreXG_c658DkJvKNlTQsWHw_5gjNszwuie1BHyGdpRomQjZC-fox2hijRKMHaBLnM-EEJUy-VLdMF5R3reyx36fTd5PMdw3xSfFpwgP-A44vm4rFNcDDbB4fwAAVsTrE_YgcMhFgzBJm-yx2asQlziCtbMlZotBL-lqoAwwQAlJryduGpULUssk09mPdY1NtjGKaZyusi690K1eDUFfCgZ_4Iy4UcoMMN9fIVejGbO_vXTe4V-fPl8d_21uf1-8-36021jeSdKw52SoySOGyp65SgVpB25GFpJectHQYiRousHNXQjawenBtH3xrC-htYpMvIr9O7su6b4c_O56AWy9fNsgo9b1qytqVFGeV9RdkZtijknP-o1wWLSUVOiT_Xogz7Vo0_1aFJHyCp6--S_DYt3_yR_-6jAxzPg6y8fwSedbc3DegfJ26JdhP_5_wHPXqH8</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Ju, Hyun Jeong</creator><creator>Han, Ju Hee</creator><creator>Kim, Min-Soo</creator><creator>Lee, Si-Hyung</creator><creator>Shin, Jung-Won</creator><creator>Choi, Mira</creator><creator>Jeong, Ki-Heon</creator><creator>Han, Tae Young</creator><creator>Choi, Chong Won</creator><creator>Lee, Hee Jung</creator><creator>Oh, Sang Ho</creator><creator>Lee, Sang Hoon</creator><creator>Kim, Dong Hyun</creator><creator>Shin, Jeonghyun</creator><creator>Lee, Jong Hee</creator><creator>Kim, Sang Seok</creator><creator>Kang, Hee Young</creator><creator>Chang, Sung Eun</creator><creator>Kim, Jeong-Soo</creator><creator>Lee, Dong-Youn</creator><creator>Choi, Gwang Seong</creator><creator>Suh, Dae Hun</creator><creator>Chan Kim, You</creator><creator>Park, Chul Jong</creator><creator>Kim, Ki-Ho</creator><creator>Lee, Ai-Young</creator><creator>Chan Park, Kyoung</creator><creator>Lee, Mu-Hyoung</creator><creator>Bae, Jung Min</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202106</creationdate><title>The long-term risk of lymphoma and skin cancer did not increase after topical calcineurin inhibitor use and phototherapy in a cohort of 25,694 patients with vitiligo</title><author>Ju, Hyun Jeong ; Han, Ju Hee ; Kim, Min-Soo ; Lee, Si-Hyung ; Shin, Jung-Won ; Choi, Mira ; Jeong, Ki-Heon ; Han, Tae Young ; Choi, Chong Won ; Lee, Hee Jung ; Oh, Sang Ho ; Lee, Sang Hoon ; Kim, Dong Hyun ; Shin, Jeonghyun ; Lee, Jong Hee ; Kim, Sang Seok ; Kang, Hee Young ; Chang, Sung Eun ; Kim, Jeong-Soo ; Lee, Dong-Youn ; Choi, Gwang Seong ; Suh, Dae Hun ; Chan Kim, You ; Park, Chul Jong ; Kim, Ki-Ho ; Lee, Ai-Young ; Chan Park, Kyoung ; Lee, Mu-Hyoung ; Bae, Jung Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-3d97f70d3a1689d11604f36b471343f600a7658b9b5f24bd9b688aa28109590f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>actinic keratosis</topic><topic>excimer laser</topic><topic>lymphoma</topic><topic>melanoma</topic><topic>narrowband ultraviolet B</topic><topic>skin cancer</topic><topic>tacrolimus</topic><topic>vitiligo</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ju, Hyun Jeong</creatorcontrib><creatorcontrib>Han, Ju Hee</creatorcontrib><creatorcontrib>Kim, Min-Soo</creatorcontrib><creatorcontrib>Lee, Si-Hyung</creatorcontrib><creatorcontrib>Shin, Jung-Won</creatorcontrib><creatorcontrib>Choi, Mira</creatorcontrib><creatorcontrib>Jeong, Ki-Heon</creatorcontrib><creatorcontrib>Han, Tae Young</creatorcontrib><creatorcontrib>Choi, Chong Won</creatorcontrib><creatorcontrib>Lee, Hee Jung</creatorcontrib><creatorcontrib>Oh, Sang Ho</creatorcontrib><creatorcontrib>Lee, Sang Hoon</creatorcontrib><creatorcontrib>Kim, Dong Hyun</creatorcontrib><creatorcontrib>Shin, Jeonghyun</creatorcontrib><creatorcontrib>Lee, Jong Hee</creatorcontrib><creatorcontrib>Kim, Sang Seok</creatorcontrib><creatorcontrib>Kang, Hee Young</creatorcontrib><creatorcontrib>Chang, Sung Eun</creatorcontrib><creatorcontrib>Kim, Jeong-Soo</creatorcontrib><creatorcontrib>Lee, Dong-Youn</creatorcontrib><creatorcontrib>Choi, Gwang Seong</creatorcontrib><creatorcontrib>Suh, Dae Hun</creatorcontrib><creatorcontrib>Chan Kim, You</creatorcontrib><creatorcontrib>Park, Chul Jong</creatorcontrib><creatorcontrib>Kim, Ki-Ho</creatorcontrib><creatorcontrib>Lee, Ai-Young</creatorcontrib><creatorcontrib>Chan Park, Kyoung</creatorcontrib><creatorcontrib>Lee, Mu-Hyoung</creatorcontrib><creatorcontrib>Bae, Jung Min</creatorcontrib><creatorcontrib>Korean Society for Vitiligo and the Korean Society for Photomedicine</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ju, Hyun Jeong</au><au>Han, Ju Hee</au><au>Kim, Min-Soo</au><au>Lee, Si-Hyung</au><au>Shin, Jung-Won</au><au>Choi, Mira</au><au>Jeong, Ki-Heon</au><au>Han, Tae Young</au><au>Choi, Chong Won</au><au>Lee, Hee Jung</au><au>Oh, Sang Ho</au><au>Lee, Sang Hoon</au><au>Kim, Dong Hyun</au><au>Shin, Jeonghyun</au><au>Lee, Jong Hee</au><au>Kim, Sang Seok</au><au>Kang, Hee Young</au><au>Chang, Sung Eun</au><au>Kim, Jeong-Soo</au><au>Lee, Dong-Youn</au><au>Choi, Gwang Seong</au><au>Suh, Dae Hun</au><au>Chan Kim, You</au><au>Park, Chul Jong</au><au>Kim, Ki-Ho</au><au>Lee, Ai-Young</au><au>Chan Park, Kyoung</au><au>Lee, Mu-Hyoung</au><au>Bae, Jung Min</au><aucorp>Korean Society for Vitiligo and the Korean Society for Photomedicine</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The long-term risk of lymphoma and skin cancer did not increase after topical calcineurin inhibitor use and phototherapy in a cohort of 25,694 patients with vitiligo</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2021-06</date><risdate>2021</risdate><volume>84</volume><issue>6</issue><spage>1619</spage><epage>1627</epage><pages>1619-1627</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><abstract>Topical calcineurin inhibitors have been used to treat vitiligo, either alone or in combination with phototherapy; however, the long-term safety of these agents remains controversial.
To investigate the risk of lymphoma and skin cancer in vitiligo patients who received topical calcineurin inhibitors or phototherapy.
A multicenter retrospective cohort study of 25,694 vitiligo patients who received topical calcineurin inhibitors or phototherapy for 6 weeks or more between 2001 and 2019 was performed. Cumulative doses of topical calcineurin inhibitors and total phototherapy sessions were determined. Outcomes were the development of lymphoma or skin cancer after enrollment, confirmed through chart review and pathology reports.
During 95,203 person-years, 13 cases of lymphoma, 22 of actinic keratosis, 15 of nonmelanoma skin cancer, and 5 of melanoma were observed. The risk of lymphoma and skin cancer was not significantly increased by topical calcineurin inhibitor dose or phototherapy sessions. The interaction between the topical calcineurin inhibitors and phototherapy was not associated with an increased risk of skin cancer.
Retrospective study, individual follow-up duration less than 4 years, and no adjustment for comorbidities and medication history. Not generalizable to other races.
The long-term risk of skin cancer or lymphoma was not associated with the use of topical calcineurin inhibitors, phototherapy, and both treatments in combination in patients with vitiligo.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33508387</pmid><doi>10.1016/j.jaad.2021.01.067</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0190-9622 |
| ispartof | Journal of the American Academy of Dermatology, 2021-06, Vol.84 (6), p.1619-1627 |
| issn | 0190-9622 1097-6787 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2483812138 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | actinic keratosis excimer laser lymphoma melanoma narrowband ultraviolet B skin cancer tacrolimus vitiligo |
| title | The long-term risk of lymphoma and skin cancer did not increase after topical calcineurin inhibitor use and phototherapy in a cohort of 25,694 patients with vitiligo |
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