Efficacy of Pomegranate Seed Powder on Glucose and Lipid Metabolism in Patients with Type 2 Diabetes: A Prospective Randomized Double-Blind Placebo-Controlled Clinical Trial

Efficacy of Pomegranate Seed Powder on Glucose and Lipid Metabolism in Patients with Type 2 Diabetes: A Prospective Randomized Double-Blind Placebo-Controlled Clinical Trial

Introduction: Pomegranate is known as a functional food which has multiple health-promoting activities. It has been assessed for patients with metabolic syndrome. Specifically, an antidiabetic activity of its juice and plausible mechanisms for its action have been shown in multitudinous studies. The...

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Veröffentlicht in:Complementary medicine research 2021-06, Vol.28 (3), p.226-233
Hauptverfasser: Seyed Hashemi, Monire, Namiranian, Nasim, Tavahen, Hemaseh, Dehghanpour, Abolfazl, Rad, Mohammad Hadi, Jam-Ashkezari, Saeedeh, Emtiazy, Majid, Hashempur, Mohammad Hashem
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container_issue 3
container_start_page 226
container_title Complementary medicine research
container_volume 28
creator Seyed Hashemi, Monire
Namiranian, Nasim
Tavahen, Hemaseh
Dehghanpour, Abolfazl
Rad, Mohammad Hadi
Jam-Ashkezari, Saeedeh
Emtiazy, Majid
Hashempur, Mohammad Hashem
description Introduction: Pomegranate is known as a functional food which has multiple health-promoting activities. It has been assessed for patients with metabolic syndrome. Specifically, an antidiabetic activity of its juice and plausible mechanisms for its action have been shown in multitudinous studies. The aim of this study was assessing the effects of complementary treatment with pomegranate seed powder (PSP) oral supplementation on patients with type 2 diabetes mellitus (T2DM). Methods: Sixty patients were treated for 8 weeks by 5 g PSP or placebo, twice daily. Fasting blood glucose (FBG), glycated hemoglobin (HbA 1c ), total cholesterol, and triglyceride (TG) were recorded as the outcome measures at the beginning and after the intervention. The findings were analyzed using the independent t test and Mann-Whitney U test. Results: After 8 weeks, the mean differences of FBG, HbA 1c , cholesterol, and TG were significantly decreased in the PSP group when compared with the placebo group (p value
doi_str_mv 10.1159/000510986
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It has been assessed for patients with metabolic syndrome. Specifically, an antidiabetic activity of its juice and plausible mechanisms for its action have been shown in multitudinous studies. The aim of this study was assessing the effects of complementary treatment with pomegranate seed powder (PSP) oral supplementation on patients with type 2 diabetes mellitus (T2DM). Methods: Sixty patients were treated for 8 weeks by 5 g PSP or placebo, twice daily. Fasting blood glucose (FBG), glycated hemoglobin (HbA 1c ), total cholesterol, and triglyceride (TG) were recorded as the outcome measures at the beginning and after the intervention. The findings were analyzed using the independent t test and Mann-Whitney U test. Results: After 8 weeks, the mean differences of FBG, HbA 1c , cholesterol, and TG were significantly decreased in the PSP group when compared with the placebo group (p value &lt;0.05). In addition, post-intervention values of FBG and HbA 1c were significantly lower in patients treated with PSP compared to the placebo group (p values = 0.02 and 0.01, respectively). However, the latter comparison regarding cholesterol and TG showed no significant differences (p values = 0.51 and 0.26, respectively). Conclusion: It seems that complementary treatment with PSP may have beneficial effects on FBG and HbA 1c of patients with T2DM. However, its effect on TG and cholesterol was equivocal.</description><identifier>ISSN: 2504-2092</identifier><identifier>EISSN: 2504-2106</identifier><identifier>DOI: 10.1159/000510986</identifier><identifier>PMID: 33302270</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Research Article / Originalarbeit</subject><ispartof>Complementary medicine research, 2021-06, Vol.28 (3), p.226-233</ispartof><rights>2020 S. 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It has been assessed for patients with metabolic syndrome. Specifically, an antidiabetic activity of its juice and plausible mechanisms for its action have been shown in multitudinous studies. The aim of this study was assessing the effects of complementary treatment with pomegranate seed powder (PSP) oral supplementation on patients with type 2 diabetes mellitus (T2DM). Methods: Sixty patients were treated for 8 weeks by 5 g PSP or placebo, twice daily. Fasting blood glucose (FBG), glycated hemoglobin (HbA 1c ), total cholesterol, and triglyceride (TG) were recorded as the outcome measures at the beginning and after the intervention. The findings were analyzed using the independent t test and Mann-Whitney U test. Results: After 8 weeks, the mean differences of FBG, HbA 1c , cholesterol, and TG were significantly decreased in the PSP group when compared with the placebo group (p value &lt;0.05). In addition, post-intervention values of FBG and HbA 1c were significantly lower in patients treated with PSP compared to the placebo group (p values = 0.02 and 0.01, respectively). However, the latter comparison regarding cholesterol and TG showed no significant differences (p values = 0.51 and 0.26, respectively). Conclusion: It seems that complementary treatment with PSP may have beneficial effects on FBG and HbA 1c of patients with T2DM. 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In addition, post-intervention values of FBG and HbA 1c were significantly lower in patients treated with PSP compared to the placebo group (p values = 0.02 and 0.01, respectively). However, the latter comparison regarding cholesterol and TG showed no significant differences (p values = 0.51 and 0.26, respectively). Conclusion: It seems that complementary treatment with PSP may have beneficial effects on FBG and HbA 1c of patients with T2DM. However, its effect on TG and cholesterol was equivocal.</abstract><cop>Basel, Switzerland</cop><pmid>33302270</pmid><doi>10.1159/000510986</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6700-9304</orcidid><oa>free_for_read</oa></addata></record>
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title Efficacy of Pomegranate Seed Powder on Glucose and Lipid Metabolism in Patients with Type 2 Diabetes: A Prospective Randomized Double-Blind Placebo-Controlled Clinical Trial
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