Vitamin D deficiency worsens maternal diabetes induced neurodevelopmental disorder by potentiating hyperglycemia‐mediated epigenetic changes

Many studies have shown that vitamin D (VD) deficiency may be a risk factor for neurodevelopmental disorders, such as autism spectrum disorders (ASDs) and schizophrenia, although causative mechanisms remain unknown. In this study, we investigated the potential role and effect of VD on maternal diabe...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2021-05, Vol.1491 (1), p.74-88
Hauptverfasser:	Liang, Yujie, Yu, Hong, Ke, Xiaoyin, Eyles, Darryl, Sun, Ruoyu, Wang, Zichen, Huang, Saijun, Lin, Ling, McGrath, John J., Lu, Jianping, Guo, Xiaoling, Yao, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics Animal models Animals Autism autism spectrum disorders Autistic Disorder - complications Autistic Disorder - genetics Autistic Disorder - pathology Calciferol Calcitriol Calcitriol - metabolism Cells (biology) Diabetes Diabetes mellitus Diabetes, Gestational - pathology Disorders Epigenetics Female Heme Oxygenase-1 - metabolism Humans Hydroxylase Hyperglycemia Inflammation Mental disorders Mice Mice, Inbred C57BL Mice, Knockout Neural stem cells Neurodevelopmental disorders NF-E2-Related Factor 2 - metabolism Offspring Oxidative stress Oxidative Stress - physiology Phenotypes Pregnancy Progenitor cells Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism Risk analysis Risk factors Schizophrenia Superoxide dismutase Superoxide Dismutase - metabolism VDR Vitamin D Vitamin D Deficiency - etiology Vitamin D Deficiency - pathology Vitamin D receptors Vitamin deficiency
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