Genetic variants in glutamate-, Aβ−, and tau-related pathways determine polygenic risk for Alzheimer's disease

Synapse loss is an early event in late-onset Alzheimer's disease (LOAD). In this study, we have assessed the capacity of a polygenic risk score (PRS) restricted to synapse-encoding loci to predict LOAD. We used summary statistics from the International Genetics of Alzheimer's Project genom...

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Veröffentlicht in:	Neurobiology of aging 2021-05, Vol.101, p.299.e13-299.e21
Hauptverfasser:	Lawingco, Ted, Chaudhury, Sultan, Brookes, Keeley J., Guetta-Baranes, Tamar, Guerreiro, Rita, Bras, Jose, Hardy, John, Francis, Paul, Thomas, Alan, Belbin, Olivia, Morgan, Kevin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - genetics Amyloid beta-Peptides - metabolism Female Genetic Predisposition to Disease - genetics Genetic Variation - genetics Genetic Variation - physiology Genome-Wide Association Study Glutamate signaling Glutamates - metabolism Humans Late-onset Alzheimer's disease Male Multifactorial Inheritance - genetics Polygenic risk score Polymorphism, Single Nucleotide Risk Factors Signal Transduction - genetics Signal Transduction - physiology tau Proteins - metabolism Tau1
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