Regulation of Toll-like receptor-mediated inflammatory response by microRNA-152-3p-mediated demethylation of MyD88 in systemic lupus erythematosus

Objective microRNAs (miRNAs) play critical roles in embryogenesis, cell differentiation and the pathogenesis of several human diseases, including systemic lupus erythematosus (SLE). Toll-like receptors (TLRs) are also known to exert crucial functions in the immune response activation occurring in th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Inflammation research 2021-03, Vol.70 (3), p.285-296
Hauptverfasser:	Tao, Bei, Xiang, Wei, Li, Xianglong, He, Chengsong, Chen, Ligang, Xia, Xiangguo, Peng, Tangming, Peng, Lilei, Yang, Xiaobo, Zhong, Chuanhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Allergology Animals Antibodies, Anti-Idiotypic - blood Antibodies, Antinuclear - blood Arthralgia Arthralgia - genetics Arthralgia - immunology Autoimmune diseases Biomedical and Life Sciences Biomedicine CD4 antigen CD40L protein CD70 antigen Cell differentiation Child Chronic conditions Correlation analysis Cytokines - immunology Demethylation Deoxyribonucleic acid Dermatology Differentiation (biology) DNA DNA (Cytosine-5-)-Methyltransferase 1 - genetics DNA (Cytosine-5-)-Methyltransferase 1 - immunology DNA methylation DNA methyltransferase DNMT1 protein Embryogenesis Embryonic growth stage Erythema Erythema - genetics Erythema - immunology Face Female Flow cytometry Humans IgG antibody Immune response Immune system Immunoglobulin G Immunology In vivo methods and tests Inflammation Inflammation - genetics Inflammation - immunology Inflammatory response Leukocytes (mononuclear) Leukocytes, Mononuclear - immunology Lupus Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lymphocytes Lymphocytes T Male Mice Mice, Inbred MRL lpr MicroRNAs Middle Aged miRNA MyD88 protein Myeloid Differentiation Factor 88 - immunology Neurology Original Research Paper Pain Pathogenesis Peripheral blood mononuclear cells Pharmacology/Toxicology Proteins Receptors Rheumatology Ribonucleic acid RNA Signal transduction Systemic lupus erythematosus Toll-like receptors Toll-Like Receptors - immunology Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!