APOE genotype influences P3b amplitude and response to smoking abstinence in young adults
Rationale There is strong evidence that nicotine can enhance cognitive functions and growing evidence that this effect may be larger in young healthy APOE ε4 carriers. However, the moderating effects of the APOE ε4 allele on cognitive impairments caused by nicotine deprivation in chronic smokers hav...
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| Veröffentlicht in: | Psychopharmacology 2021-04, Vol.238 (4), p.1171-1181 |
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| container_title | Psychopharmacology |
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| creator | Coppens, Ryan Rabinovich, Norka E. Kanneganti, Raghuveer Diggs, Herman A. Wiggs, Kristin Healey, Travis Huggenvik, Jodi Rose, Gregory M. Gilbert, David G. |
| description | Rationale
There is strong evidence that nicotine can enhance cognitive functions and growing evidence that this effect may be larger in young healthy
APOE
ε4 carriers. However, the moderating effects of the
APOE
ε4 allele on cognitive impairments caused by nicotine deprivation in chronic smokers have not yet been studied with brain indices.
Objective
We sought to determine whether young female carriers of the
APOE
ε4 allele, relative to noncarriers, would exhibit larger abstinence-induced decreases in P3b amplitude during a two-stimulus auditory oddball task.
Methods
We compared parietal P3bs in female chronic smokers with either
APOE
ε3/ε3 (
n
= 54) or ε3/ε4 (
n
= 20) genotype under nicotine-sated conditions and after 12–17-h nicotine deprivation.
Results
Nicotine deprivation significantly reduced P3b amplitudes in
APOE
ε4 carriers, but not in
APOE-
ε3/ε3 individuals, such that the difference seen prior to nicotine deprivation was eliminated.
Conclusions
The results suggest that subjects with the
APOE
ε4 allele are more sensitive to nicotine, which could influence smoking patterns, the risk for nicotine dependence, and the cognitive effects of nicotine use in these individuals. |
| doi_str_mv | 10.1007/s00213-021-05763-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2482666197</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A656116718</galeid><sourcerecordid>A656116718</sourcerecordid><originalsourceid>FETCH-LOGICAL-c393t-b69920432e5b32dff651170daefdea5bc720b413616ca35275438902061f3f503</originalsourceid><addsrcrecordid>eNp9kU9v1DAQxS0EokvhC3BAlrhwSRl7Yic5rqryR6rUHuDAyXKS8SolsYOdHPbb12ELFQhhS2Np_HtPYz_GXgu4EADV-wQgBRa5FKAqjYV6wnaiRFlIqORTtgNALFCo-oy9SOkO8irr8jk7Q1SgEcod-7a_vbniB_JhOc7EB-_GlXxHid9iy-00j8Oy9sSt73mkNAefiC-Bpyl8H_yB2zYtg98UWcuPYd16_Tou6SV75uyY6NXDec6-frj6cvmpuL75-Plyf1102OBStLppJOShSbUoe-e0EqKC3pLryaq2qyS0pUAtdGdRyUqVWDcgQQuHTgGes3cn3zmGHyulxUxD6mgcraewJiPLWmqtRVNl9O1f6F1Yo8_TGak2SwStH6mDHcnkHwlLtN1mavZaaSF0JepMXfyDyrunaeiCJzfk_h8CeRJ0MaQUyZk5DpONRyPAbHmaU54mF_MzT6Oy6M3DxGs7Uf9b8ivADOAJSPnKHyg-Puk_tveXNqdr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2502063066</pqid></control><display><type>article</type><title>APOE genotype influences P3b amplitude and response to smoking abstinence in young adults</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Coppens, Ryan ; Rabinovich, Norka E. ; Kanneganti, Raghuveer ; Diggs, Herman A. ; Wiggs, Kristin ; Healey, Travis ; Huggenvik, Jodi ; Rose, Gregory M. ; Gilbert, David G.</creator><creatorcontrib>Coppens, Ryan ; Rabinovich, Norka E. ; Kanneganti, Raghuveer ; Diggs, Herman A. ; Wiggs, Kristin ; Healey, Travis ; Huggenvik, Jodi ; Rose, Gregory M. ; Gilbert, David G.</creatorcontrib><description>Rationale
There is strong evidence that nicotine can enhance cognitive functions and growing evidence that this effect may be larger in young healthy
APOE
ε4 carriers. However, the moderating effects of the
APOE
ε4 allele on cognitive impairments caused by nicotine deprivation in chronic smokers have not yet been studied with brain indices.
Objective
We sought to determine whether young female carriers of the
APOE
ε4 allele, relative to noncarriers, would exhibit larger abstinence-induced decreases in P3b amplitude during a two-stimulus auditory oddball task.
Methods
We compared parietal P3bs in female chronic smokers with either
APOE
ε3/ε3 (
n
= 54) or ε3/ε4 (
n
= 20) genotype under nicotine-sated conditions and after 12–17-h nicotine deprivation.
Results
Nicotine deprivation significantly reduced P3b amplitudes in
APOE
ε4 carriers, but not in
APOE-
ε3/ε3 individuals, such that the difference seen prior to nicotine deprivation was eliminated.
Conclusions
The results suggest that subjects with the
APOE
ε4 allele are more sensitive to nicotine, which could influence smoking patterns, the risk for nicotine dependence, and the cognitive effects of nicotine use in these individuals.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-021-05763-5</identifier><identifier>PMID: 33506304</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abstinence ; Acoustic Stimulation ; Adult ; Alleles ; Analysis ; Apolipoprotein E ; Apolipoprotein E3 - genetics ; Apolipoproteins ; Biomedical and Life Sciences ; Biomedicine ; Care and treatment ; Cognitive ability ; Drug dependence ; Electroencephalography - drug effects ; Evoked potentials (Electrophysiology) ; Female ; Genetic aspects ; Genotype ; Genotypes ; Heterozygote ; Humans ; Identification and classification ; Influence ; Male ; Neurosciences ; Nicotine ; Nicotine - pharmacology ; Nicotinic Agonists - pharmacology ; Original Investigation ; Parietal Lobe - physiopathology ; Pharmacology/Toxicology ; Physiological aspects ; Psychiatry ; Psychomotor Performance - drug effects ; Smoking ; Smoking - genetics ; Smoking - psychology ; Smoking and youth ; Smoking Cessation - psychology ; Young Adult ; Young adults</subject><ispartof>Psychopharmacology, 2021-04, Vol.238 (4), p.1171-1181</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c393t-b69920432e5b32dff651170daefdea5bc720b413616ca35275438902061f3f503</cites><orcidid>0000-0001-7525-7239</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00213-021-05763-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00213-021-05763-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33506304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coppens, Ryan</creatorcontrib><creatorcontrib>Rabinovich, Norka E.</creatorcontrib><creatorcontrib>Kanneganti, Raghuveer</creatorcontrib><creatorcontrib>Diggs, Herman A.</creatorcontrib><creatorcontrib>Wiggs, Kristin</creatorcontrib><creatorcontrib>Healey, Travis</creatorcontrib><creatorcontrib>Huggenvik, Jodi</creatorcontrib><creatorcontrib>Rose, Gregory M.</creatorcontrib><creatorcontrib>Gilbert, David G.</creatorcontrib><title>APOE genotype influences P3b amplitude and response to smoking abstinence in young adults</title><title>Psychopharmacology</title><addtitle>Psychopharmacology</addtitle><addtitle>Psychopharmacology (Berl)</addtitle><description>Rationale
There is strong evidence that nicotine can enhance cognitive functions and growing evidence that this effect may be larger in young healthy
APOE
ε4 carriers. However, the moderating effects of the
APOE
ε4 allele on cognitive impairments caused by nicotine deprivation in chronic smokers have not yet been studied with brain indices.
Objective
We sought to determine whether young female carriers of the
APOE
ε4 allele, relative to noncarriers, would exhibit larger abstinence-induced decreases in P3b amplitude during a two-stimulus auditory oddball task.
Methods
We compared parietal P3bs in female chronic smokers with either
APOE
ε3/ε3 (
n
= 54) or ε3/ε4 (
n
= 20) genotype under nicotine-sated conditions and after 12–17-h nicotine deprivation.
Results
Nicotine deprivation significantly reduced P3b amplitudes in
APOE
ε4 carriers, but not in
APOE-
ε3/ε3 individuals, such that the difference seen prior to nicotine deprivation was eliminated.
Conclusions
The results suggest that subjects with the
APOE
ε4 allele are more sensitive to nicotine, which could influence smoking patterns, the risk for nicotine dependence, and the cognitive effects of nicotine use in these individuals.</description><subject>Abstinence</subject><subject>Acoustic Stimulation</subject><subject>Adult</subject><subject>Alleles</subject><subject>Analysis</subject><subject>Apolipoprotein E</subject><subject>Apolipoprotein E3 - genetics</subject><subject>Apolipoproteins</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Care and treatment</subject><subject>Cognitive ability</subject><subject>Drug dependence</subject><subject>Electroencephalography - drug effects</subject><subject>Evoked potentials (Electrophysiology)</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>Influence</subject><subject>Male</subject><subject>Neurosciences</subject><subject>Nicotine</subject><subject>Nicotine - pharmacology</subject><subject>Nicotinic Agonists - pharmacology</subject><subject>Original Investigation</subject><subject>Parietal Lobe - physiopathology</subject><subject>Pharmacology/Toxicology</subject><subject>Physiological aspects</subject><subject>Psychiatry</subject><subject>Psychomotor Performance - drug effects</subject><subject>Smoking</subject><subject>Smoking - genetics</subject><subject>Smoking - psychology</subject><subject>Smoking and youth</subject><subject>Smoking Cessation - psychology</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9v1DAQxS0EokvhC3BAlrhwSRl7Yic5rqryR6rUHuDAyXKS8SolsYOdHPbb12ELFQhhS2Np_HtPYz_GXgu4EADV-wQgBRa5FKAqjYV6wnaiRFlIqORTtgNALFCo-oy9SOkO8irr8jk7Q1SgEcod-7a_vbniB_JhOc7EB-_GlXxHid9iy-00j8Oy9sSt73mkNAefiC-Bpyl8H_yB2zYtg98UWcuPYd16_Tou6SV75uyY6NXDec6-frj6cvmpuL75-Plyf1102OBStLppJOShSbUoe-e0EqKC3pLryaq2qyS0pUAtdGdRyUqVWDcgQQuHTgGes3cn3zmGHyulxUxD6mgcraewJiPLWmqtRVNl9O1f6F1Yo8_TGak2SwStH6mDHcnkHwlLtN1mavZaaSF0JepMXfyDyrunaeiCJzfk_h8CeRJ0MaQUyZk5DpONRyPAbHmaU54mF_MzT6Oy6M3DxGs7Uf9b8ivADOAJSPnKHyg-Puk_tveXNqdr</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Coppens, Ryan</creator><creator>Rabinovich, Norka E.</creator><creator>Kanneganti, Raghuveer</creator><creator>Diggs, Herman A.</creator><creator>Wiggs, Kristin</creator><creator>Healey, Travis</creator><creator>Huggenvik, Jodi</creator><creator>Rose, Gregory M.</creator><creator>Gilbert, David G.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7525-7239</orcidid></search><sort><creationdate>20210401</creationdate><title>APOE genotype influences P3b amplitude and response to smoking abstinence in young adults</title><author>Coppens, Ryan ; Rabinovich, Norka E. ; Kanneganti, Raghuveer ; Diggs, Herman A. ; Wiggs, Kristin ; Healey, Travis ; Huggenvik, Jodi ; Rose, Gregory M. ; Gilbert, David G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-b69920432e5b32dff651170daefdea5bc720b413616ca35275438902061f3f503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abstinence</topic><topic>Acoustic Stimulation</topic><topic>Adult</topic><topic>Alleles</topic><topic>Analysis</topic><topic>Apolipoprotein E</topic><topic>Apolipoprotein E3 - genetics</topic><topic>Apolipoproteins</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Care and treatment</topic><topic>Cognitive ability</topic><topic>Drug dependence</topic><topic>Electroencephalography - drug effects</topic><topic>Evoked potentials (Electrophysiology)</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Identification and classification</topic><topic>Influence</topic><topic>Male</topic><topic>Neurosciences</topic><topic>Nicotine</topic><topic>Nicotine - pharmacology</topic><topic>Nicotinic Agonists - pharmacology</topic><topic>Original Investigation</topic><topic>Parietal Lobe - physiopathology</topic><topic>Pharmacology/Toxicology</topic><topic>Physiological aspects</topic><topic>Psychiatry</topic><topic>Psychomotor Performance - drug effects</topic><topic>Smoking</topic><topic>Smoking - genetics</topic><topic>Smoking - psychology</topic><topic>Smoking and youth</topic><topic>Smoking Cessation - psychology</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coppens, Ryan</creatorcontrib><creatorcontrib>Rabinovich, Norka E.</creatorcontrib><creatorcontrib>Kanneganti, Raghuveer</creatorcontrib><creatorcontrib>Diggs, Herman A.</creatorcontrib><creatorcontrib>Wiggs, Kristin</creatorcontrib><creatorcontrib>Healey, Travis</creatorcontrib><creatorcontrib>Huggenvik, Jodi</creatorcontrib><creatorcontrib>Rose, Gregory M.</creatorcontrib><creatorcontrib>Gilbert, David G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coppens, Ryan</au><au>Rabinovich, Norka E.</au><au>Kanneganti, Raghuveer</au><au>Diggs, Herman A.</au><au>Wiggs, Kristin</au><au>Healey, Travis</au><au>Huggenvik, Jodi</au><au>Rose, Gregory M.</au><au>Gilbert, David G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>APOE genotype influences P3b amplitude and response to smoking abstinence in young adults</atitle><jtitle>Psychopharmacology</jtitle><stitle>Psychopharmacology</stitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>238</volume><issue>4</issue><spage>1171</spage><epage>1181</epage><pages>1171-1181</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>Rationale
There is strong evidence that nicotine can enhance cognitive functions and growing evidence that this effect may be larger in young healthy
APOE
ε4 carriers. However, the moderating effects of the
APOE
ε4 allele on cognitive impairments caused by nicotine deprivation in chronic smokers have not yet been studied with brain indices.
Objective
We sought to determine whether young female carriers of the
APOE
ε4 allele, relative to noncarriers, would exhibit larger abstinence-induced decreases in P3b amplitude during a two-stimulus auditory oddball task.
Methods
We compared parietal P3bs in female chronic smokers with either
APOE
ε3/ε3 (
n
= 54) or ε3/ε4 (
n
= 20) genotype under nicotine-sated conditions and after 12–17-h nicotine deprivation.
Results
Nicotine deprivation significantly reduced P3b amplitudes in
APOE
ε4 carriers, but not in
APOE-
ε3/ε3 individuals, such that the difference seen prior to nicotine deprivation was eliminated.
Conclusions
The results suggest that subjects with the
APOE
ε4 allele are more sensitive to nicotine, which could influence smoking patterns, the risk for nicotine dependence, and the cognitive effects of nicotine use in these individuals.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33506304</pmid><doi>10.1007/s00213-021-05763-5</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-7525-7239</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-3158 |
| ispartof | Psychopharmacology, 2021-04, Vol.238 (4), p.1171-1181 |
| issn | 0033-3158 1432-2072 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2482666197 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Abstinence Acoustic Stimulation Adult Alleles Analysis Apolipoprotein E Apolipoprotein E3 - genetics Apolipoproteins Biomedical and Life Sciences Biomedicine Care and treatment Cognitive ability Drug dependence Electroencephalography - drug effects Evoked potentials (Electrophysiology) Female Genetic aspects Genotype Genotypes Heterozygote Humans Identification and classification Influence Male Neurosciences Nicotine Nicotine - pharmacology Nicotinic Agonists - pharmacology Original Investigation Parietal Lobe - physiopathology Pharmacology/Toxicology Physiological aspects Psychiatry Psychomotor Performance - drug effects Smoking Smoking - genetics Smoking - psychology Smoking and youth Smoking Cessation - psychology Young Adult Young adults |
| title | APOE genotype influences P3b amplitude and response to smoking abstinence in young adults |
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