Novel anoplin‐based (lipo)‐peptide models show potent antimicrobial activity

The subject of this study is the synthesis and biological evaluation of anoplin‐based (Gly‐Leu‐Leu3‐Lys‐Arg5‐Ile‐Lys‐Thr8‐Leu‐Leu‐NH2)—designed (lipo)‐peptides, aiming at the development of new antibiotic substances. The design of synthetic compounds based on natural bioactive molecules is an optimi...

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Veröffentlicht in:	Journal of peptide science 2021-04, Vol.27 (4), p.e3303-n/a
Hauptverfasser:	Stergiou, Vasileios, Krikorian, Dimitrios, Koukkou, Anna‐Irini, Sakarellos‐Daitsiotis, Maria, Panou‐Pomonis, Eugenia
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation amphipathic α‐helical peptides Analogs anoplin analogs Antibiotics Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents antimicrobial lipopeptides Antimicrobial peptides antimicrobial peptides (AMP) Bacteria Circular dichroism circular dichroism spectroscopy Dichroism Gram-negative bacteria hemolytic assay Minimum inhibitory concentration Peptides Pharmaceutical sciences Spectroscopy Synthetic peptides
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