Absence of CCR2 reduces spontaneous intestinal tumorigenesis in the ApcMin/+ mouse model

The biological activities of chemokine (C‐C motif) ligand 2 (CCL2) are mediated via C‐C chemokine receptor‐2 (CCR2). Increased CCL2 level is associated with metastasis of many cancers. In our study, we investigated the role of the CCL2/CCR2 axis in the development of spontaneous intestinal tumorigen...

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Veröffentlicht in:	International journal of cancer 2021-05, Vol.148 (10), p.2594-2607
Hauptverfasser:	Jala, Venkatakrishna Rao, Bodduluri, Sobha Rani, Ghosh, Sweta, Chheda, Zinal, Singh, Rajbir, Smith, Michelle E., Chilton, Paula M., Fleming, Christopher J., Mathis, Steven Paul, Sharma, Rajesh Kumar, Knight, Rob, Yan, Jun, Haribabu, Bodduluri
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer ApcMin/+ mice Cancer CC chemokine receptors CCR2 CCR2 protein CD4 antigen Cell proliferation Chemokine receptors Chemokines Colitis Granzyme B IL‐17 intestinal tumorigenesis Intestine Leukocyte migration Lymph nodes Lymphocytes Lymphocytes T Macrophages Medical research Metastases Monocyte chemoattractant protein 1 Phenotypes RAG2 protein Spleen Tumorigenesis Tumors γ-Interferon
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