Mobility performance impacts mortality risk in community-dwelling healthy older adults in Japan: a prospective observational study
Background The timed up and go (TUG) test assesses balance and mobility performance. Aim This study aims to investigate the association between TUG time and mortality in Japanese older persons and to clarify possible moderation effects on mortality and TUG time. Methods In all, 874 participants who...
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| Veröffentlicht in: | Aging clinical and experimental research 2021-09, Vol.33 (9), p.2511-2517 |
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| container_title | Aging clinical and experimental research |
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| creator | Otsuka, Hiromasa Kobayashi, Hiroki Suzuki, Kiyozumi Hayashi, Yuta Ikeda, Jin Kushimoto, Masaru Hara, Motohiko Abe, Masanori Kato, Kimitoshi Soma, Masayoshi |
| description | Background
The timed up and go (TUG) test assesses balance and mobility performance.
Aim
This study aims to investigate the association between TUG time and mortality in Japanese older persons and to clarify possible moderation effects on mortality and TUG time.
Methods
In all, 874 participants who were ≥ 65 years of age completed the TUG test and had their anthropometric parameters and physical functions measured. We investigated the association between all-cause mortality and TUG using a Cox regression model that included confounders, and explored the time associated with mortality using a restricted cubic spline. We also performed subgroup analyses to explore whether age, sex, and body mass index (BMI) affected the relationship between TUG time and mortality.
Results
The median age and mean follow-up period were 74 and 8.5 years, respectively. Median TUG time was 7.4 s and the prevalence of mortality was 25.7%. TUG time in one second was positively associated with an increased risk of total mortality [hazard ratio (HR): 1.054 (1.016–1.093);
P
= 0.005] in the Cox regression model. The positive association of mortality and TUG time was present when the TUG was over 10.5 s in the restricted cubic spline curve. Older age (75 years or older) moderated the relationship between TUG time and mortality [
P
interaction
= 0.096].
Conclusion
This study demonstrates that TUG time is associated with all-cause mortality in Japanese older adults. |
| doi_str_mv | 10.1007/s40520-021-01787-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2481116733</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2570669344</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-4ae50978a192883d0c089358beac515a691d7f94fc4eb823e29b0ea94c148c883</originalsourceid><addsrcrecordid>eNp9kctu1TAQhi0EoqXwAiyQJTZsAp7YOXHYoarcVMQG1tbEmbQuSRxsp-hseXKGnnIRC1a2Z75_Lv6FeAzqOSjVvshGNbWqVA2Vgta2FdwRx9ByyGro7v51PxIPcr5SygA_7osjrU2363RzLL5_iH2YQtnLldIY04yLJxnmFX3Jco6p4E02hfxFhkX6OM_bwpFq-EbTFJYLeUk4lcu9jNNASeKwTaxk9D2uuLyUKNcU80q-hGuSsc-UrrGEuOAkc9mG_UNxb8Qp06Pb80R8fn326fRtdf7xzbvTV-eVNwZKZZAa1bUWoaut1YPyyvIKtif0DTS462Box86M3lBva0111yvCzngw1rPiRDw71OV5vm6Ui5tD9rwELhS37GpjAWDXas3o03_Qq7glnpipplU7_jtjmKoPlOcFc6LRrSnMmPYOlPvpkDs45Nghd-OQAxY9uS299TMNvyW_LGFAH4DMqeWC0p_e_yn7AwH_neo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2570669344</pqid></control><display><type>article</type><title>Mobility performance impacts mortality risk in community-dwelling healthy older adults in Japan: a prospective observational study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Otsuka, Hiromasa ; Kobayashi, Hiroki ; Suzuki, Kiyozumi ; Hayashi, Yuta ; Ikeda, Jin ; Kushimoto, Masaru ; Hara, Motohiko ; Abe, Masanori ; Kato, Kimitoshi ; Soma, Masayoshi</creator><creatorcontrib>Otsuka, Hiromasa ; Kobayashi, Hiroki ; Suzuki, Kiyozumi ; Hayashi, Yuta ; Ikeda, Jin ; Kushimoto, Masaru ; Hara, Motohiko ; Abe, Masanori ; Kato, Kimitoshi ; Soma, Masayoshi</creatorcontrib><description>Background
The timed up and go (TUG) test assesses balance and mobility performance.
Aim
This study aims to investigate the association between TUG time and mortality in Japanese older persons and to clarify possible moderation effects on mortality and TUG time.
Methods
In all, 874 participants who were ≥ 65 years of age completed the TUG test and had their anthropometric parameters and physical functions measured. We investigated the association between all-cause mortality and TUG using a Cox regression model that included confounders, and explored the time associated with mortality using a restricted cubic spline. We also performed subgroup analyses to explore whether age, sex, and body mass index (BMI) affected the relationship between TUG time and mortality.
Results
The median age and mean follow-up period were 74 and 8.5 years, respectively. Median TUG time was 7.4 s and the prevalence of mortality was 25.7%. TUG time in one second was positively associated with an increased risk of total mortality [hazard ratio (HR): 1.054 (1.016–1.093);
P
= 0.005] in the Cox regression model. The positive association of mortality and TUG time was present when the TUG was over 10.5 s in the restricted cubic spline curve. Older age (75 years or older) moderated the relationship between TUG time and mortality [
P
interaction
= 0.096].
Conclusion
This study demonstrates that TUG time is associated with all-cause mortality in Japanese older adults.</description><identifier>ISSN: 1720-8319</identifier><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/s40520-021-01787-1</identifier><identifier>PMID: 33496935</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Age ; Aged ; Aged, 80 and over ; Body mass index ; Geriatric Assessment ; Geriatrics/Gerontology ; Health Status ; Humans ; Independent Living ; Internal medicine ; Japan - epidemiology ; Medical prognosis ; Medicine ; Medicine & Public Health ; Mobility ; Mortality ; Observational studies ; Older people ; Original Article ; Postural Balance ; Prospective Studies ; Questionnaires</subject><ispartof>Aging clinical and experimental research, 2021-09, Vol.33 (9), p.2511-2517</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-4ae50978a192883d0c089358beac515a691d7f94fc4eb823e29b0ea94c148c883</citedby><cites>FETCH-LOGICAL-c441t-4ae50978a192883d0c089358beac515a691d7f94fc4eb823e29b0ea94c148c883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40520-021-01787-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40520-021-01787-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33496935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Otsuka, Hiromasa</creatorcontrib><creatorcontrib>Kobayashi, Hiroki</creatorcontrib><creatorcontrib>Suzuki, Kiyozumi</creatorcontrib><creatorcontrib>Hayashi, Yuta</creatorcontrib><creatorcontrib>Ikeda, Jin</creatorcontrib><creatorcontrib>Kushimoto, Masaru</creatorcontrib><creatorcontrib>Hara, Motohiko</creatorcontrib><creatorcontrib>Abe, Masanori</creatorcontrib><creatorcontrib>Kato, Kimitoshi</creatorcontrib><creatorcontrib>Soma, Masayoshi</creatorcontrib><title>Mobility performance impacts mortality risk in community-dwelling healthy older adults in Japan: a prospective observational study</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><addtitle>Aging Clin Exp Res</addtitle><description>Background
The timed up and go (TUG) test assesses balance and mobility performance.
Aim
This study aims to investigate the association between TUG time and mortality in Japanese older persons and to clarify possible moderation effects on mortality and TUG time.
Methods
In all, 874 participants who were ≥ 65 years of age completed the TUG test and had their anthropometric parameters and physical functions measured. We investigated the association between all-cause mortality and TUG using a Cox regression model that included confounders, and explored the time associated with mortality using a restricted cubic spline. We also performed subgroup analyses to explore whether age, sex, and body mass index (BMI) affected the relationship between TUG time and mortality.
Results
The median age and mean follow-up period were 74 and 8.5 years, respectively. Median TUG time was 7.4 s and the prevalence of mortality was 25.7%. TUG time in one second was positively associated with an increased risk of total mortality [hazard ratio (HR): 1.054 (1.016–1.093);
P
= 0.005] in the Cox regression model. The positive association of mortality and TUG time was present when the TUG was over 10.5 s in the restricted cubic spline curve. Older age (75 years or older) moderated the relationship between TUG time and mortality [
P
interaction
= 0.096].
Conclusion
This study demonstrates that TUG time is associated with all-cause mortality in Japanese older adults.</description><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Body mass index</subject><subject>Geriatric Assessment</subject><subject>Geriatrics/Gerontology</subject><subject>Health Status</subject><subject>Humans</subject><subject>Independent Living</subject><subject>Internal medicine</subject><subject>Japan - epidemiology</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mobility</subject><subject>Mortality</subject><subject>Observational studies</subject><subject>Older people</subject><subject>Original Article</subject><subject>Postural Balance</subject><subject>Prospective Studies</subject><subject>Questionnaires</subject><issn>1720-8319</issn><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kctu1TAQhi0EoqXwAiyQJTZsAp7YOXHYoarcVMQG1tbEmbQuSRxsp-hseXKGnnIRC1a2Z75_Lv6FeAzqOSjVvshGNbWqVA2Vgta2FdwRx9ByyGro7v51PxIPcr5SygA_7osjrU2363RzLL5_iH2YQtnLldIY04yLJxnmFX3Jco6p4E02hfxFhkX6OM_bwpFq-EbTFJYLeUk4lcu9jNNASeKwTaxk9D2uuLyUKNcU80q-hGuSsc-UrrGEuOAkc9mG_UNxb8Qp06Pb80R8fn326fRtdf7xzbvTV-eVNwZKZZAa1bUWoaut1YPyyvIKtif0DTS462Box86M3lBva0111yvCzngw1rPiRDw71OV5vm6Ui5tD9rwELhS37GpjAWDXas3o03_Qq7glnpipplU7_jtjmKoPlOcFc6LRrSnMmPYOlPvpkDs45Nghd-OQAxY9uS299TMNvyW_LGFAH4DMqeWC0p_e_yn7AwH_neo</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Otsuka, Hiromasa</creator><creator>Kobayashi, Hiroki</creator><creator>Suzuki, Kiyozumi</creator><creator>Hayashi, Yuta</creator><creator>Ikeda, Jin</creator><creator>Kushimoto, Masaru</creator><creator>Hara, Motohiko</creator><creator>Abe, Masanori</creator><creator>Kato, Kimitoshi</creator><creator>Soma, Masayoshi</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20210901</creationdate><title>Mobility performance impacts mortality risk in community-dwelling healthy older adults in Japan: a prospective observational study</title><author>Otsuka, Hiromasa ; Kobayashi, Hiroki ; Suzuki, Kiyozumi ; Hayashi, Yuta ; Ikeda, Jin ; Kushimoto, Masaru ; Hara, Motohiko ; Abe, Masanori ; Kato, Kimitoshi ; Soma, Masayoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-4ae50978a192883d0c089358beac515a691d7f94fc4eb823e29b0ea94c148c883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Body mass index</topic><topic>Geriatric Assessment</topic><topic>Geriatrics/Gerontology</topic><topic>Health Status</topic><topic>Humans</topic><topic>Independent Living</topic><topic>Internal medicine</topic><topic>Japan - epidemiology</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mobility</topic><topic>Mortality</topic><topic>Observational studies</topic><topic>Older people</topic><topic>Original Article</topic><topic>Postural Balance</topic><topic>Prospective Studies</topic><topic>Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Otsuka, Hiromasa</creatorcontrib><creatorcontrib>Kobayashi, Hiroki</creatorcontrib><creatorcontrib>Suzuki, Kiyozumi</creatorcontrib><creatorcontrib>Hayashi, Yuta</creatorcontrib><creatorcontrib>Ikeda, Jin</creatorcontrib><creatorcontrib>Kushimoto, Masaru</creatorcontrib><creatorcontrib>Hara, Motohiko</creatorcontrib><creatorcontrib>Abe, Masanori</creatorcontrib><creatorcontrib>Kato, Kimitoshi</creatorcontrib><creatorcontrib>Soma, Masayoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Otsuka, Hiromasa</au><au>Kobayashi, Hiroki</au><au>Suzuki, Kiyozumi</au><au>Hayashi, Yuta</au><au>Ikeda, Jin</au><au>Kushimoto, Masaru</au><au>Hara, Motohiko</au><au>Abe, Masanori</au><au>Kato, Kimitoshi</au><au>Soma, Masayoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mobility performance impacts mortality risk in community-dwelling healthy older adults in Japan: a prospective observational study</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><addtitle>Aging Clin Exp Res</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>33</volume><issue>9</issue><spage>2511</spage><epage>2517</epage><pages>2511-2517</pages><issn>1720-8319</issn><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Background
The timed up and go (TUG) test assesses balance and mobility performance.
Aim
This study aims to investigate the association between TUG time and mortality in Japanese older persons and to clarify possible moderation effects on mortality and TUG time.
Methods
In all, 874 participants who were ≥ 65 years of age completed the TUG test and had their anthropometric parameters and physical functions measured. We investigated the association between all-cause mortality and TUG using a Cox regression model that included confounders, and explored the time associated with mortality using a restricted cubic spline. We also performed subgroup analyses to explore whether age, sex, and body mass index (BMI) affected the relationship between TUG time and mortality.
Results
The median age and mean follow-up period were 74 and 8.5 years, respectively. Median TUG time was 7.4 s and the prevalence of mortality was 25.7%. TUG time in one second was positively associated with an increased risk of total mortality [hazard ratio (HR): 1.054 (1.016–1.093);
P
= 0.005] in the Cox regression model. The positive association of mortality and TUG time was present when the TUG was over 10.5 s in the restricted cubic spline curve. Older age (75 years or older) moderated the relationship between TUG time and mortality [
P
interaction
= 0.096].
Conclusion
This study demonstrates that TUG time is associated with all-cause mortality in Japanese older adults.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33496935</pmid><doi>10.1007/s40520-021-01787-1</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Aging clinical and experimental research, 2021-09, Vol.33 (9), p.2511-2517 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Age Aged Aged, 80 and over Body mass index Geriatric Assessment Geriatrics/Gerontology Health Status Humans Independent Living Internal medicine Japan - epidemiology Medical prognosis Medicine Medicine & Public Health Mobility Mortality Observational studies Older people Original Article Postural Balance Prospective Studies Questionnaires |
| title | Mobility performance impacts mortality risk in community-dwelling healthy older adults in Japan: a prospective observational study |
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