Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes

The high disability, mortality and morbidity of diabetic ulcers make it urgent to explore effective strategies for diabetic wound repair. TrxR1 plays a vital role in regulating redox homeostasis in various pathologies. In the present study, the effect of berberine (BBR) on diabetic wounds was invest...

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Veröffentlicht in:	Clinical science (1979) 2021-02, Vol.135 (4), p.613-627
Hauptverfasser:	Zhou, Rui, Xiang, Changpei, Cao, Guangzhao, Xu, He, Zhang, Yi, Yang, Hongjun, Zhang, Jingjing
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Berberine - administration & dosage Berberine - pharmacology Cell Proliferation - drug effects Diabetes Mellitus, Experimental Diet, High-Fat - adverse effects Extracellular Matrix - metabolism Male MAP Kinase Signaling System - drug effects Rats Rats, Sprague-Dawley Thioredoxin Reductase 1 - antagonists & inhibitors Thioredoxin Reductase 1 - metabolism Wound Healing - drug effects
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