Procedural optimization of drug‐coated balloons in the treatment of coronary artery disease
Objectives This study aimed to investigate the effects of procedural optimization on the clinical outcomes of using the drug‐coated balloon (DCB) in the treatment of coronary artery disease. Backgrounds Procedural optimization is considered an essential step in DCB treatment. Methods Data of consecu...
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| Veröffentlicht in: | Catheterization and cardiovascular interventions 2021-07, Vol.98 (1), p.E43-E52 |
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| container_title | Catheterization and cardiovascular interventions |
| container_volume | 98 |
| creator | Lee, Hak Seung Kang, Jeehoon Park, Kyung Woo Ki, You‐Jeong Chang, Mineok Han, Jung‐Kyu Yang, Han‐Mo Kang, Hyun‐Jae Koo, Bon‐Kwon Kim, Hyo‐Soo |
| description | Objectives
This study aimed to investigate the effects of procedural optimization on the clinical outcomes of using the drug‐coated balloon (DCB) in the treatment of coronary artery disease.
Backgrounds
Procedural optimization is considered an essential step in DCB treatment.
Methods
Data of consecutive patients who underwent DCB treatment at the Seoul National University Hospital were collected. The primary outcome was target lesion failure (TLF) at 2 years.
Results
Among 259 patients (309 lesions), TLF was observed in 31 (12.0%) patients. The following were modifiable procedural factors: residual percent diameter stenosis (%DS) after lesion preparation; DCB‐to‐vessel/stent ratio; time‐delay to inflation; and total DCB inflation time. The best cutoff values for these parameters were 20%, 0.95, 25, and 60 s, respectively. The patients were classified based on the number of procedural factors that satisfied adequate criteria. TLF was observed in 7.3% in the fully optimized group, 9.1% in the partially optimized group, and 34.1% in the nonoptimized group over 2 years (p |
| doi_str_mv | 10.1002/ccd.29492 |
| format | Article |
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This study aimed to investigate the effects of procedural optimization on the clinical outcomes of using the drug‐coated balloon (DCB) in the treatment of coronary artery disease.
Backgrounds
Procedural optimization is considered an essential step in DCB treatment.
Methods
Data of consecutive patients who underwent DCB treatment at the Seoul National University Hospital were collected. The primary outcome was target lesion failure (TLF) at 2 years.
Results
Among 259 patients (309 lesions), TLF was observed in 31 (12.0%) patients. The following were modifiable procedural factors: residual percent diameter stenosis (%DS) after lesion preparation; DCB‐to‐vessel/stent ratio; time‐delay to inflation; and total DCB inflation time. The best cutoff values for these parameters were 20%, 0.95, 25, and 60 s, respectively. The patients were classified based on the number of procedural factors that satisfied adequate criteria. TLF was observed in 7.3% in the fully optimized group, 9.1% in the partially optimized group, and 34.1% in the nonoptimized group over 2 years (p < .001). The adequacy of the four factors for DCB optimization was an independent predictor of TLF (adjusted hazards ratio for each unmet criteria for optimization, 2.05, 95% confidence interval 1.74–2.36, p < .001).
Conclusion
The optimization of the four procedural factors could reduce TLF following DCB treatment.</description><identifier>ISSN: 1522-1946</identifier><identifier>EISSN: 1522-726X</identifier><identifier>DOI: 10.1002/ccd.29492</identifier><identifier>PMID: 33491857</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Balloon treatment ; Cardiovascular disease ; Coronary artery ; coronary artery disease ; Coronary vessels ; drug‐coated balloon ; Heart diseases ; Implants ; Lesions ; Optimization ; Patients ; percutaneous coronary intervention ; Stenosis ; Stents</subject><ispartof>Catheterization and cardiovascular interventions, 2021-07, Vol.98 (1), p.E43-E52</ispartof><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-b14a0014e979683c80721d6e66584cd6e9b01eceaae9c57a28537a1e803751023</citedby><cites>FETCH-LOGICAL-c3532-b14a0014e979683c80721d6e66584cd6e9b01eceaae9c57a28537a1e803751023</cites><orcidid>0000-0002-8188-3348 ; 0000-0003-0847-5329 ; 0000-0002-0016-0747 ; 0000-0003-2432-4432 ; 0000-0002-4569-6326</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fccd.29492$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fccd.29492$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33491857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Hak Seung</creatorcontrib><creatorcontrib>Kang, Jeehoon</creatorcontrib><creatorcontrib>Park, Kyung Woo</creatorcontrib><creatorcontrib>Ki, You‐Jeong</creatorcontrib><creatorcontrib>Chang, Mineok</creatorcontrib><creatorcontrib>Han, Jung‐Kyu</creatorcontrib><creatorcontrib>Yang, Han‐Mo</creatorcontrib><creatorcontrib>Kang, Hyun‐Jae</creatorcontrib><creatorcontrib>Koo, Bon‐Kwon</creatorcontrib><creatorcontrib>Kim, Hyo‐Soo</creatorcontrib><title>Procedural optimization of drug‐coated balloons in the treatment of coronary artery disease</title><title>Catheterization and cardiovascular interventions</title><addtitle>Catheter Cardiovasc Interv</addtitle><description>Objectives
This study aimed to investigate the effects of procedural optimization on the clinical outcomes of using the drug‐coated balloon (DCB) in the treatment of coronary artery disease.
Backgrounds
Procedural optimization is considered an essential step in DCB treatment.
Methods
Data of consecutive patients who underwent DCB treatment at the Seoul National University Hospital were collected. The primary outcome was target lesion failure (TLF) at 2 years.
Results
Among 259 patients (309 lesions), TLF was observed in 31 (12.0%) patients. The following were modifiable procedural factors: residual percent diameter stenosis (%DS) after lesion preparation; DCB‐to‐vessel/stent ratio; time‐delay to inflation; and total DCB inflation time. The best cutoff values for these parameters were 20%, 0.95, 25, and 60 s, respectively. The patients were classified based on the number of procedural factors that satisfied adequate criteria. TLF was observed in 7.3% in the fully optimized group, 9.1% in the partially optimized group, and 34.1% in the nonoptimized group over 2 years (p < .001). The adequacy of the four factors for DCB optimization was an independent predictor of TLF (adjusted hazards ratio for each unmet criteria for optimization, 2.05, 95% confidence interval 1.74–2.36, p < .001).
Conclusion
The optimization of the four procedural factors could reduce TLF following DCB treatment.</description><subject>Balloon treatment</subject><subject>Cardiovascular disease</subject><subject>Coronary artery</subject><subject>coronary artery disease</subject><subject>Coronary vessels</subject><subject>drug‐coated balloon</subject><subject>Heart diseases</subject><subject>Implants</subject><subject>Lesions</subject><subject>Optimization</subject><subject>Patients</subject><subject>percutaneous coronary intervention</subject><subject>Stenosis</subject><subject>Stents</subject><issn>1522-1946</issn><issn>1522-726X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10LtOwzAUBmALgWgpDLwAisQCQ4ovcRKPKFylSjCAxIIs1zmFVElcbEeoTDwCz8iT4JLCgMR0zvDp1zk_QvsEjwnG9ETrckxFIugGGhJOaZzR9GFzvRORpAO049wcYyxSKrbRgLFEkJxnQ_R4a42GsrOqjszCV031pnxl2sjMotJ2T5_vH9ooD2U0VXVtTOuiqo38M0TegvINtH5FtbGmVXYZKeshjLJyoBzsoq2Zqh3srecI3V-c3xVX8eTm8ro4ncSacUbjKUkUxiQBkYk0ZzrHGSVlCmnK80SHRUwxAQ1KgdA8UzTnLFMEcswyTjBlI3TU5y6seenAedlUTkNdqxZM5yRNQiRPcrqih3_o3HS2DddJGgSjPBUsqONeaWucszCTC1s14UFJsFx1LkPn8rvzYA_Wid20gfJX_pQcwEkPXqsalv8nyaI46yO_AKEXi1c</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Lee, Hak Seung</creator><creator>Kang, Jeehoon</creator><creator>Park, Kyung Woo</creator><creator>Ki, You‐Jeong</creator><creator>Chang, Mineok</creator><creator>Han, Jung‐Kyu</creator><creator>Yang, Han‐Mo</creator><creator>Kang, Hyun‐Jae</creator><creator>Koo, Bon‐Kwon</creator><creator>Kim, Hyo‐Soo</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8188-3348</orcidid><orcidid>https://orcid.org/0000-0003-0847-5329</orcidid><orcidid>https://orcid.org/0000-0002-0016-0747</orcidid><orcidid>https://orcid.org/0000-0003-2432-4432</orcidid><orcidid>https://orcid.org/0000-0002-4569-6326</orcidid></search><sort><creationdate>20210701</creationdate><title>Procedural optimization of drug‐coated balloons in the treatment of coronary artery disease</title><author>Lee, Hak Seung ; Kang, Jeehoon ; Park, Kyung Woo ; Ki, You‐Jeong ; Chang, Mineok ; Han, Jung‐Kyu ; Yang, Han‐Mo ; Kang, Hyun‐Jae ; Koo, Bon‐Kwon ; Kim, Hyo‐Soo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-b14a0014e979683c80721d6e66584cd6e9b01eceaae9c57a28537a1e803751023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Balloon treatment</topic><topic>Cardiovascular disease</topic><topic>Coronary artery</topic><topic>coronary artery disease</topic><topic>Coronary vessels</topic><topic>drug‐coated balloon</topic><topic>Heart diseases</topic><topic>Implants</topic><topic>Lesions</topic><topic>Optimization</topic><topic>Patients</topic><topic>percutaneous coronary intervention</topic><topic>Stenosis</topic><topic>Stents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Hak Seung</creatorcontrib><creatorcontrib>Kang, Jeehoon</creatorcontrib><creatorcontrib>Park, Kyung Woo</creatorcontrib><creatorcontrib>Ki, You‐Jeong</creatorcontrib><creatorcontrib>Chang, Mineok</creatorcontrib><creatorcontrib>Han, Jung‐Kyu</creatorcontrib><creatorcontrib>Yang, Han‐Mo</creatorcontrib><creatorcontrib>Kang, Hyun‐Jae</creatorcontrib><creatorcontrib>Koo, Bon‐Kwon</creatorcontrib><creatorcontrib>Kim, Hyo‐Soo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Catheterization and cardiovascular interventions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Hak Seung</au><au>Kang, Jeehoon</au><au>Park, Kyung Woo</au><au>Ki, You‐Jeong</au><au>Chang, Mineok</au><au>Han, Jung‐Kyu</au><au>Yang, Han‐Mo</au><au>Kang, Hyun‐Jae</au><au>Koo, Bon‐Kwon</au><au>Kim, Hyo‐Soo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Procedural optimization of drug‐coated balloons in the treatment of coronary artery disease</atitle><jtitle>Catheterization and cardiovascular interventions</jtitle><addtitle>Catheter Cardiovasc Interv</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>98</volume><issue>1</issue><spage>E43</spage><epage>E52</epage><pages>E43-E52</pages><issn>1522-1946</issn><eissn>1522-726X</eissn><abstract>Objectives
This study aimed to investigate the effects of procedural optimization on the clinical outcomes of using the drug‐coated balloon (DCB) in the treatment of coronary artery disease.
Backgrounds
Procedural optimization is considered an essential step in DCB treatment.
Methods
Data of consecutive patients who underwent DCB treatment at the Seoul National University Hospital were collected. The primary outcome was target lesion failure (TLF) at 2 years.
Results
Among 259 patients (309 lesions), TLF was observed in 31 (12.0%) patients. The following were modifiable procedural factors: residual percent diameter stenosis (%DS) after lesion preparation; DCB‐to‐vessel/stent ratio; time‐delay to inflation; and total DCB inflation time. The best cutoff values for these parameters were 20%, 0.95, 25, and 60 s, respectively. The patients were classified based on the number of procedural factors that satisfied adequate criteria. TLF was observed in 7.3% in the fully optimized group, 9.1% in the partially optimized group, and 34.1% in the nonoptimized group over 2 years (p < .001). The adequacy of the four factors for DCB optimization was an independent predictor of TLF (adjusted hazards ratio for each unmet criteria for optimization, 2.05, 95% confidence interval 1.74–2.36, p < .001).
Conclusion
The optimization of the four procedural factors could reduce TLF following DCB treatment.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>33491857</pmid><doi>10.1002/ccd.29492</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8188-3348</orcidid><orcidid>https://orcid.org/0000-0003-0847-5329</orcidid><orcidid>https://orcid.org/0000-0002-0016-0747</orcidid><orcidid>https://orcid.org/0000-0003-2432-4432</orcidid><orcidid>https://orcid.org/0000-0002-4569-6326</orcidid></addata></record> |
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| issn | 1522-1946 1522-726X |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Balloon treatment Cardiovascular disease Coronary artery coronary artery disease Coronary vessels drug‐coated balloon Heart diseases Implants Lesions Optimization Patients percutaneous coronary intervention Stenosis Stents |
| title | Procedural optimization of drug‐coated balloons in the treatment of coronary artery disease |
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